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GJA8 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-190702
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Connexin 50
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Gap junction trafficking and regulation (Homo sapiens)
Gap junction trafficking (Homo sapiens)
Gap junction assembly (Homo sapiens)
Connexin synthesis (generic) (Homo sapiens)
Monomeric connexin protein [endoplasmic reticulum membrane] (Homo sapiens)
GJA8 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48165 GJA8
Gene Names
GJA8
Chain
initiator methionine:, chain:2-433
Reference Genes
BioGPS Gene:2703 GJA8
COSMIC (genes):GJA8 GJA8
CTD Gene:2703 GJA8
dbSNP Gene:2703 GJA8
ENSEMBL:ENSG00000121634 GJA8
HGNC:4281 GJA8
KEGG:hsa:2703 GJA8
Monarch:2703 GJA8
NCBI Gene:2703 GJA8
OMIM:600897 GJA8
UCSC:P48165 GJA8
Reference Transcript
RefSeq:XM_011509416.1 GJA8
RefSeq:NM_005267.4 GJA8
Other Identifiers
11743209_at
16670138
208489_PM_at
208489_at
2356980
2356982
2356983
2356984
2356985
2356986
2703
31778_at
4043714
4043718
4043719
4043720
4043721
7904927
GE62272
GO:0002088
GO:0005215
GO:0005243
GO:0005515
GO:0005886
GO:0005921
GO:0005922
GO:0007154
GO:0007267
GO:0023052
GO:0032645
GO:0042802
GO:0043010
GO:0048856
GO:0055085
GO:1990349
HMNXSV003011325
ILMN_1686867
PH_hs_0009531
TC01001117.hg
g4885274_3p_at
Participates
as a candidate of
Monomeric connexin protein [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
Gja8 [endoplasmic reticulum membrane]
(Mus musculus)
Gja8 [endoplasmic reticulum membrane]
(Rattus norvegicus)
GJA8 [endoplasmic reticulum membrane]
(Bos taurus)
GJA8 [endoplasmic reticulum membrane]
(Canis familiaris)
GJA8 [endoplasmic reticulum membrane]
(Gallus gallus)
GJA8 [endoplasmic reticulum membrane]
(Sus scrofa)
Cross References
RefSeq
NP_005258.2
,
XP_011507718.1
Guide to Pharmacology - Targets
732
OpenTargets
ENSG00000121634
ENSEMBL
ENSP00000358238
,
ENST00000369235
HPA
ENSG00000121634-GJA8
PRO
P48165
Pharos - Targets
P48165
Orphanet
GJA8
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8TDU9 RXFP4
1
RXFP4 [plasma membrane]
(R-HSA-444826)
0.556
3
UniProt:P29033 GJB2
3
GJB2 [endoplasmic reticulum-Golgi intermediate compartment]
(R-HSA-190614)
GJB2 [endoplasmic reticulum membrane]
(R-HSA-1629779)
GJB2 [plasma membrane]
(R-HSA-53211)
0.556
3
UniProt:P02652 APOA2
6
APOA2(24-100) [cytosol]
(R-HSA-2395772)
APOA2(24-100) [early endosome]
(R-HSA-2569092)
APOA2(24-100) [endoplasmic reticulum lumen]
(R-HSA-174689)
APOA2(24-100) [extracellular region]
(R-HSA-174775)
p-APOA2 [endoplasmic reticulum lumen]
(R-HSA-8957014)
APOA2 [endoplasmic reticulum lumen]
(R-HSA-8956780)
0.556
3
UniProt:P37268 FDFT1
1
FDFT1 [endoplasmic reticulum membrane]
(R-HSA-191369)
0.556
3
UniProt:Q9UPQ8 DOLK
6
DOLK [endoplasmic reticulum membrane]
(R-HSA-449274)
DOLK M1I [endoplasmic reticulum membrane]
(R-HSA-4755593)
DOLK H408D [endoplasmic reticulum membrane]
(R-HSA-4755548)
DOLK C99S [endoplasmic reticulum membrane]
(R-HSA-4755602)
DOLK W304C [endoplasmic reticulum membrane]
(R-HSA-4755557)
DOLK Y441S [endoplasmic reticulum membrane]
(R-HSA-4755590)
0.556
3
UniProt:O43561-2 LAT
2
p-5Y-LAT-2 [plasma membrane]
(R-HSA-2396597)
LAT-2 [plasma membrane]
(R-HSA-2396548)
0.556
3
UniProt:Q8N8N0 RNF152
1
RNF152 [lysosomal membrane]
(R-HSA-8938832)
0.556
3
UniProt:P11686 SFTPC
9
pro-SFTPC P115L [endoplasmic reticulum membrane]
(R-HSA-5688352)
pro-SFTPC P30L [endoplasmic reticulum membrane]
(R-HSA-5688365)
pro-SFTPC [endoplasmic reticulum membrane]
(R-HSA-5683842)
pro-SFTPC [multivesicular body lumen]
(R-HSA-5685298)
SFTPC [extracellular region]
(R-HSA-5683685)
SFTPC [clathrin-coated endocytic vesicle]
(R-HSA-5686342)
SFTPC [lamellar body]
(R-HSA-5683717)
SFTPC(24-58) [multivesicular body lumen]
(R-HSA-5685899)
SFTPC(59-197) [multivesicular body lumen]
(R-HSA-5685871)
0.556
3
UniProt:Q9BPV8 P2RY13
1
P2RY13 [plasma membrane]
(R-HSA-417871)
0.556
3
UniProt:Q15436 SEC23A
4
SEC23A [endoplasmic reticulum membrane]
(R-HSA-203976)
SEC23A [cytosol]
(R-HSA-203972)
SEC23A [ER to Golgi transport vesicle membrane]
(R-HSA-204024)
p-S738,T744 SEC23A [cytosol]
(R-HSA-5685740)
0.556
3
UniProt:Q92504 SLC39A7
1
SLC39A7 [endoplasmic reticulum membrane]
(R-HSA-442363)
0.556
3
UniProt:O75396 SEC22B
6
SEC22B [endoplasmic reticulum membrane]
(R-HSA-5688150)
SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688566)
SEC22B [ER to Golgi transport vesicle membrane]
(R-HSA-5688565)
SEC22B [phagocytic vesicle membrane]
(R-HSA-8863938)
SEC22B [transport vesicle]
(R-HSA-6810994)
SEC22B [Golgi membrane]
(R-HSA-6810993)
0.556
3
UniProt:Q01453 PMP22
1
PMP22 [plasma membrane]
(R-HSA-9615623)
0.556
3
UniProt:Q8N661 TMEM86B
1
TMEM86B [endoplasmic reticulum membrane]
(R-HSA-8874443)
0.556
3
UniProt:Q86YT5 SLC13A5
1
SLC13A5 [plasma membrane]
(R-HSA-433135)
0.556
3
UniProt:P24593 IGFBP5
5
IGFBP5 [endoplasmic reticulum lumen]
(R-HSA-8956738)
p-IGFBP5 [endoplasmic reticulum lumen]
(R-HSA-8956988)
IGFBP5 [extracellular region]
(R-HSA-381414)
IGFBP5(21-163) [extracellular region]
(R-HSA-381415)
IGFBP5(164-272) [extracellular region]
(R-HSA-381478)
0.556
3
UniProt:Q96P65 QRFPR
1
QRFPR [plasma membrane]
(R-HSA-389504)
0.556
3
UniProt:P05090 APOD
1
APOD [extracellular region]
(R-HSA-5216199)
0.556
3
UniProt:O95070 YIF1A
1
YIF1A [endoplasmic reticulum membrane]
(R-HSA-535599)
0.556
3
UniProt:Q99437 ATP6V0B
3
ATP6V0B [endosome membrane]
(R-HSA-912584)
ATP6V0B [phagocytic vesicle membrane]
(R-HSA-1222695)
ATP6V0B [lysosomal membrane]
(R-HSA-9640187)
0.556
3
UniProt:O00590 ACKR2
1
ACKR2 [plasma membrane]
(R-HSA-443955)
0.556
3
UniProt:Q14162 SCARF1
2
SCARF1 [plasma membrane]
(R-HSA-2197636)
SCARF1 [endocytic vesicle membrane]
(R-HSA-2239453)
0.556
3
UniProt:Q969I6 SLC38A4
1
SLC38A4 [plasma membrane]
(R-HSA-352134)
0.556
3
UniProt:Q13183 SLC13A2
1
SLC13A2 [plasma membrane]
(R-HSA-433093)
0.556
3
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