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GOSR1 [Golgi membrane]
Stable Identifier
R-HSA-6807753
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
GOS28
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNARES [Golgi membrane] (Homo sapiens)
GOSR1:BET1:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:BET1L:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:GOSR2:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
cis-Golgi cis SNARE bundle [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNARES [Golgi membrane] (Homo sapiens)
GOSR1:BET1:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:BET1L:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:GOSR2:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
cis-SNARE:3xSNAP:NSF hexamer [Golgi membrane] (Homo sapiens)
cis-Golgi cis SNARE bundle [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNARES [Golgi membrane] (Homo sapiens)
GOSR1:BET1:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:BET1L:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:GOSR2:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
cis-Golgi cis-SNARE binds NSF and SNAPs (Homo sapiens)
cis-Golgi cis SNARE bundle [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNARES [Golgi membrane] (Homo sapiens)
GOSR1:BET1:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:BET1L:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:GOSR2:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
cis-SNARE:3xSNAP:NSF hexamer [Golgi membrane] (Homo sapiens)
cis-Golgi cis SNARE bundle [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNARES [Golgi membrane] (Homo sapiens)
GOSR1:BET1:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:BET1L:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:GOSR2:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNARES [Golgi membrane] (Homo sapiens)
GOSR1:BET1:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:BET1L:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:GOSR2:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNARES [Golgi membrane] (Homo sapiens)
GOSR1:BET1:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:BET1L:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:GOSR2:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNARES [Golgi membrane] (Homo sapiens)
GOSR1:BET1:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:BET1L:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:GOSR2:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
cis-Golgi cis SNARE bundle [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNARES [Golgi membrane] (Homo sapiens)
GOSR1:BET1:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:BET1L:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:GOSR2:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
cis-SNARE:3xSNAP:NSF hexamer [Golgi membrane] (Homo sapiens)
cis-Golgi cis SNARE bundle [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNARES [Golgi membrane] (Homo sapiens)
GOSR1:BET1:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:BET1L:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:GOSR2:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
cis-Golgi cis-SNARE binds NSF and SNAPs (Homo sapiens)
cis-Golgi cis SNARE bundle [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNARES [Golgi membrane] (Homo sapiens)
GOSR1:BET1:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:BET1L:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:GOSR2:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
cis-SNARE:3xSNAP:NSF hexamer [Golgi membrane] (Homo sapiens)
cis-Golgi cis SNARE bundle [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNARES [Golgi membrane] (Homo sapiens)
GOSR1:BET1:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:BET1L:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:GOSR2:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNARES [Golgi membrane] (Homo sapiens)
GOSR1:BET1:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:BET1L:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:GOSR2:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNARES [Golgi membrane] (Homo sapiens)
GOSR1:BET1:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:BET1L:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:GOSR2:STX5 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Intra-Golgi traffic (Homo sapiens)
ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
STX5:PalmC-YKT6:BET1L:GOSR1:NSF hexamer:3xSNAPs [Golgi membrane] (Homo sapiens)
STX:PalmC-YKT6:BET1L:GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
Formation of cis-SNARE complex and membrane fusion in intra-Golgi retrograde traffic (Homo sapiens)
COG complex:CUX1 dimer:GOLGA5 dimer:STX5:PalmC-YKT6:BET1L:GOSR1:intra-Golgi retrograde cargo [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
STX:PalmC-YKT6:BET1L:GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
NSF and SNAPs bind the cis-SNARE at the Golgi (Homo sapiens)
STX5:PalmC-YKT6:BET1L:GOSR1:NSF hexamer:3xSNAPs [Golgi membrane] (Homo sapiens)
STX:PalmC-YKT6:BET1L:GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
STX:PalmC-YKT6:BET1L:GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
The COG complex and CUX1 and GOLGA5 dimers contribute to intra-Golgi vesicle tethering (Homo sapiens)
COG complex:CUX1 dimer:GOLGA5 dimer:STX5:PalmC-YKT6:BET1L:GOSR1:intra-Golgi retrograde cargo [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Homo sapiens)
COG complex:Golgi snares [Golgi membrane] (Homo sapiens)
other COG interacting snares [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
other COG interacting snares [Golgi membrane] (Homo sapiens)
GOSR1 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95249 GOSR1
Gene Names
GOSR1, GS28
Chain
initiator methionine:, chain:2-250
Reference Genes
BioGPS Gene:9527 GOSR1
COSMIC (genes):GOSR1 GOSR1
CTD Gene:9527 GOSR1
dbSNP Gene:9527 GOSR1
ENSEMBL:ENSG00000108587 GOSR1
HGNC:4430 GOSR1
KEGG:hsa:9527 GOSR1
Monarch:9527 GOSR1
NCBI Gene:9527 GOSR1
OMIM:604026 GOSR1
UCSC:O95249 GOSR1
Reference Transcript
RefSeq:NM_004871.2 GOSR1
RefSeq:NM_001007025.1 GOSR1
RefSeq:NM_001007024.1 GOSR1
RefSeq:XM_005258072.2 GOSR1
Other Identifiers
11723529_x_at
11723530_a_at
11723531_a_at
11762838_at
11762894_at
1555199_PM_at
1555199_at
16832792
204630_PM_s_at
204630_s_at
213020_PM_at
213020_at
213021_PM_at
213021_at
33723_at
3715297
3716482
3716483
3716485
3716486
3716487
3716488
3716491
3716492
3716493
3716494
3716498
3716499
3716505
3716506
3716507
3716512
3716513
3716514
3716516
3716517
3716518
3716519
3716520
3716521
3716522
3716523
40725_at
73801_at
8006148
9527
A_14_P114307
A_24_P169462
A_32_P217330
A_33_P3279431
GE54689
GE87308
GO:0000139
GO:0005484
GO:0005794
GO:0005797
GO:0005801
GO:0005829
GO:0006888
GO:0006891
GO:0006906
GO:0015031
GO:0016020
GO:0016192
GO:0030133
GO:0031201
GO:0031410
GO:0042147
GO:0043226
GO:0048219
GO:0060090
GO:0061024
HMNXSV003057984
Hs.194051.0.S1_3p_at
Hs.194051.0.S2_3p_at
ILMN_1798816
ILMN_2401033
PH_hs_0022373
PH_hs_0031612
TC17000350.hg
g4758455_3p_a_at
Participates
as a member of
other COG interacting snares [Golgi membrane] (Homo sapiens)
as a component of
COG complex:CUX1 dimer:GOLGA5 dimer:STX5:PalmC-YKT6:BET1L:GOSR1:intra-Golgi retrograde cargo [Golgi membrane] (Homo sapiens)
STX:PalmC-YKT6:BET1L:GOSR1 [Golgi membrane] (Homo sapiens)
GOSR1:BET1:STX5 [Golgi membrane] (Homo sapiens)
GOSR1:BET1L:STX5 [Golgi membrane] (Homo sapiens)
GOSR1:GOSR2:STX5 [Golgi membrane] (Homo sapiens)
as an output of
ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane (Homo sapiens)
NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Homo sapiens)
Other forms of this molecule
GOSR1 [transport vesicle]
Inferred To
GOS1 [Golgi membrane]
(Saccharomyces cerevisiae)
GOSR1 [Golgi membrane]
(Bos taurus)
GOSR1 [Golgi membrane]
(Canis familiaris)
GOSR1 [Golgi membrane]
(Dictyostelium discoideum)
GOSR1 [Golgi membrane]
(Gallus gallus)
GOSR1 [Golgi membrane]
(Plasmodium falciparum)
GOSR1 [Golgi membrane]
(Sus scrofa)
Ghost homologue of GOSR1 [Golgi membrane]
(Danio rerio)
Gosr1 [Golgi membrane]
(Mus musculus)
Gosr1 [Golgi membrane]
(Rattus norvegicus)
Gos28 [Golgi membrane]
(Drosophila melanogaster)
gos1 [Golgi membrane]
(Schizosaccharomyces pombe)
gos-28 [Golgi membrane]
(Caenorhabditis elegans)
gosr1 [Golgi membrane]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENST00000225724
,
ENST00000467337
,
ENSP00000462638
,
ENSP00000225724
OpenTargets
ENSG00000108587
HPA
ENSG00000108587-GOSR1
PRO
O95249
Pharos - Targets
O95249
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15155 BET1
3
BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688142)
BET1 [transport vesicle]
(R-HSA-6808719)
BET1 [Golgi membrane]
(R-HSA-6807743)
0.569
3
UniProt:Q8WVM8 SCFD1
1
SCFD1 [cytosol]
(R-HSA-5688147)
0.527
2
UniProt:Q9NZ43 USE1
1
USE1 [endoplasmic reticulum membrane]
(R-HSA-2193119)
0.527
2
UniProt:P46459 NSF
1
NSF [cytosol]
(R-HSA-264471)
0.527
2
UniProt:O75396 SEC22B
6
SEC22B [endoplasmic reticulum membrane]
(R-HSA-5688150)
SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688566)
SEC22B [ER to Golgi transport vesicle membrane]
(R-HSA-5688565)
SEC22B [phagocytic vesicle membrane]
(R-HSA-8863938)
SEC22B [transport vesicle]
(R-HSA-6810994)
SEC22B [Golgi membrane]
(R-HSA-6810993)
0.527
3
UniProt:P54920 NAPA
1
NAPA [cytosol]
(R-HSA-264469)
0.527
3
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