GSDME(1-270) W44C [cytosol]

Stable Identifier
R-HSA-9710470
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Gasdermin-E (1-270) W44C, Gasdermin-E, N-terminal
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
32188940 Gasdermin E suppresses tumour growth by activating anti-tumour immunity

Mok, TMY, Sengupta, S, Li, S, Meza-Sosa, KF, Junqueira, C, Zhang, Y, Ansara, J, Zhang, Z, Liu, X, Lieberman, J, Wu, H, Yao, Y, Kong, Q, Xia, S

Nature 2020
External Reference Information
External Reference
UniProt:O60443 GSDME
Gene Names
GSDME, DFNA5, ICERE1
Chain
chain:1-496, chain:1-270, chain:271-496
Reference Genes
BioGPS Gene:1687 GSDME
COSMIC (genes):GSDME GSDME
CTD Gene:1687 GSDME
dbSNP Gene:1687 GSDME
ENSEMBL:ENSG00000105928 GSDME
HGNC:2810 GSDME
KEGG Gene (Homo sapiens):1687 GSDME
Monarch:1687 GSDME
NCBI Gene:1687 GSDME
OMIM:608798 GSDME
UCSC:O60443 GSDME
Reference Transcript
Other Identifiers
0006550050
11719194_a_at
1687
17055910
203695_s_at
3041817
3041818
3041819
3041820
3041826
3041828
3041829
3041835
3041836
3041837
3041844
3041847
3041848
3041849
3041860
3041861
3041864
3041865
3041866
41872_at
8138602
A_23_P82449
A_33_P3221293
GE54686
GO:0003674
GO:0005515
GO:0005546
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0005886
GO:0006464
GO:0007165
GO:0007605
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0008289
GO:0012501
GO:0016020
GO:0016021
GO:0030154
GO:0043167
GO:0043410
GO:0048856
GO:0050877
GO:0060113
GO:0070265
GO:0070269
GO:0071356
GO:0098586
GO:1901612
GO:2001244
HMNXSV003001929
HMNXSV003019197
ILMN_1670145
PH_hs_0023638
g4758153_3p_a_at
Participates
as a member of
Other forms of this molecule
GSDME(1-270) G199E [cytosol]
GSDME(1-270) R48I [cytosol]
GSDME(1-270) I137T [cytosol]
GSDME W46* [cytosol]
GSDME(1-270) D18V [cytosol]
GSDME(1-270) D14Y [cytosol]
GSDME(1-270) P212L [cytosol]
GSDME(1-270) I217N [cytosol]
GSDME E210* [cytosol]
GSDME(1-270) [cytosol]
GSDME [cytosol]
GSDME (271-496) [cytosol]
GSDME(1-270) E177V [cytosol]
GSDME(1-270) T196M [cytosol]
GSDME(1-270) G17D [cytosol]
GSDME(1-270) E134A [cytosol]
GSDME(1-270) N24D [cytosol]
Modified Residues
Name
L-tryptophan 44 replaced with L-cysteine
Coordinate
44
PsiMod
L-cysteine residue [MOD:00014]
A protein modification that effectively converts a source amino acid residue to an L-cysteine.
L-tryptophan removal [MOD:01648]
A protein modification that effectively removes or replaces an L-tryptophan.
Disease
Name Identifier Synonyms
lung adenocarcinoma DOID:3910 nonsmall cell adenocarcinoma
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
OpenTargets
GeneCards
HPA
Ensembl
PRO
Pharos - Targets
Interactors (1)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q96CG3 TIFA  2 0.556 3
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