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ELMO2 [cytosol]
Stable Identifier
R-HSA-372642
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Engulfment and cell motility protein 2
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
CRKII:DOCK180:ELMO binds FCGR3A (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO2 [cytosol] (Homo sapiens)
IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:CRKII:DOCK180:ELMO [plasma membrane] (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO2 [cytosol] (Homo sapiens)
DOCK180 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO2 [cytosol] (Homo sapiens)
IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:CRKII:DOCK180:ELMO [plasma membrane] (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Activation of RAC1 by CRKII:DOCK180:ELMO (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO2 [cytosol] (Homo sapiens)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO2 [cytosol] (Homo sapiens)
Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO2 [cytosol] (Homo sapiens)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
Activation of RAC1 by the PXN:CRK complex (Homo sapiens)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO2 [cytosol] (Homo sapiens)
Phosphorylated PXN recruits the CRK complex (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO2 [cytosol] (Homo sapiens)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO2 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
DOCK180:ELMO binds CRK (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO2 [cytosol] (Homo sapiens)
DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO2 [cytosol] (Homo sapiens)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO2 [cytosol] (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO1,ELMO2 [cytosol] (Homo sapiens)
ELMO2 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOG GTPase cycle (Homo sapiens)
RHOG binds effectors at the plasma membrane (Homo sapiens)
RHOG plasma membrane effectors [cytosol] (Homo sapiens)
ELMO2 [cytosol] (Homo sapiens)
RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Homo sapiens)
RHOG plasma membrane effectors [cytosol] (Homo sapiens)
ELMO2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96JJ3 ELMO2
Gene Names
ELMO2, CED12A, KIAA1834
Chain
chain:1-720
Reference Genes
BioGPS Gene:63916 ELMO2
COSMIC (genes):ELMO2 ELMO2
CTD Gene:63916 ELMO2
dbSNP Gene:63916 ELMO2
ENSEMBL:ENSG00000062598 ELMO2
ENSEMBL:ENSG00000062598.18 ELMO2
HGNC:17233 ELMO2
KEGG Gene (Homo sapiens):63916 ELMO2
Monarch:63916 ELMO2
NCBI Gene:63916 ELMO2
OMIM:606421 ELMO2
UCSC:Q96JJ3 ELMO2
Reference Transcript
RefSeq:XM_005260498.3 ELMO2
RefSeq:XM_005260499.3 ELMO2
RefSeq:XM_005260500.3 ELMO2
RefSeq:NM_133171.4 ELMO2
RefSeq:NM_182764.2 ELMO2
RefSeq:NM_001318253.1 ELMO2
RefSeq:XM_006723854.3 ELMO2
RefSeq:XM_005260496.3 ELMO2
Other Identifiers
11719106_a_at
11752203_a_at
16919828
220363_PM_s_at
220363_s_at
221528_PM_s_at
221528_s_at
3613246
3613250
3907831
3907832
3907833
3907834
3907835
3907836
3907837
3907840
3907841
3907842
3907843
3907845
3907847
3907850
3907851
3907852
3907856
3907862
3907864
3907866
3907871
3907873
3907874
3907875
3907876
3907877
3907878
3907879
3907884
55692_PM_at
55692_at
62814_at
63916
77761_at
77764_g_at
8066716
A_23_P210538
A_24_P187993
A_24_P322635
GE82650
GO:0005515
GO:0005737
GO:0005829
GO:0006909
GO:0006915
GO:0007010
GO:0007015
GO:0012501
GO:0016020
GO:0016192
GO:0017124
GO:0030971
GO:0048870
GO:0060326
HMNXSV003037529
ILMN_1778168
ILMN_2244889
ILMN_2317730
PH_hs_0022964
TC20000900.hg
g11545798_3p_a_at
g12652782_3p_s_at
Participates
as a candidate of
RHOG plasma membrane effectors [cytosol] (Homo sapiens)
as a member of
ELMO1,ELMO2 [cytosol] (Homo sapiens)
Inferred To
elmoA [cytosol]
(Dictyostelium discoideum)
Ced-12 [cytosol]
(Drosophila melanogaster)
LMO1 [cytosol]
(Saccharomyces cerevisiae)
ced-12 [cytosol]
(Caenorhabditis elegans)
elmo2 [cytosol]
(Xenopus tropicalis)
Elmo2 [cytosol]
(Mus musculus)
Elmo2 [cytosol]
(Rattus norvegicus)
ELMO2 [cytosol]
(Bos taurus)
ELMO2 [cytosol]
(Canis familiaris)
ELMO2 [cytosol]
(Danio rerio)
ELMO2 [cytosol]
(Gallus gallus)
ELMO2 [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_005260557.1
,
NP_001305182.1
,
XP_005260555.1
,
XP_006723917.1
,
XP_005260556.1
,
XP_005260553.1
,
NP_573403.1
,
NP_877496.1
OpenTargets
ENSG00000062598
HPA
ENSG00000062598-ELMO2
GeneCards
Q96JJ3
Ensembl
ENSP00000290246
,
ENST00000372176
,
ENSG00000062598
,
ENST00000290246
,
ENSP00000379673
,
ENST00000396391
,
ENSP00000361249
PRO
Q96JJ3
Pharos - Targets
Q96JJ3
Orphanet
24100
HMDB Protein
HMDBP11504
PDB
6IDX
,
6IE1
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.643
4
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