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SMG8 [cytosol]
Stable Identifier
R-HSA-927759
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein SMG8, SMG8_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
SMG1:SMG8:SMG9 Complex [cytosol] (Homo sapiens)
SMG8 [cytosol] (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
SMG1:SMG8:SMG9 Complex [cytosol] (Homo sapiens)
SMG8 [cytosol] (Homo sapiens)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
SMG1:SMG8:SMG9 Complex [cytosol] (Homo sapiens)
SMG8 [cytosol] (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
SMG1:SMG8:SMG9 Complex [cytosol] (Homo sapiens)
SMG8 [cytosol] (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
SMG1:SMG8:SMG9 Complex [cytosol] (Homo sapiens)
SMG8 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8ND04 SMG8
Gene Names
SMG8, ABC2, C17orf71
Chain
chain:1-991
Reference Genes
BioGPS Gene:55181 SMG8
COSMIC (genes):SMG8 SMG8
CTD Gene:55181 SMG8
dbSNP Gene:55181 SMG8
ENSEMBL:ENSG00000167447 SMG8
HGNC:25551 SMG8
KEGG:hsa:55181 SMG8
Monarch:55181 SMG8
NCBI Gene:55181 SMG8
OMIM:613175 SMG8
UCSC:Q8ND04 SMG8
Reference Transcript
RefSeq:NM_018149.6 SMG8
Other Identifiers
11720182_at
16836504
218514_PM_at
218514_at
3729003
3729004
3729005
3729006
3729007
3729008
3729009
3729010
3729011
3729012
3729013
55181
64921_at
8008795
A_23_P66563
A_24_P402090
GE55797
GO:0000184
GO:0005515
GO:0005575
GO:0005829
GO:0016071
GO:0045859
HMNXSV003006777
ILMN_1807533
PH_hs_0000751
TC17000719.hg
g8922539_3p_s_at
g8922539_3p_x_at
Participates
as a component of
SMG1:SMG8:SMG9 Complex [cytosol] (Homo sapiens)
Inferred To
Ghost homologue of SMG8 [cytosol]
(Danio rerio)
Ghost homologue of SMG8 [cytosol]
(Gallus gallus)
Ghost homologue of SMG8 [cytosol]
(Plasmodium falciparum)
Ghost homologue of SMG8 [cytosol]
(Saccharomyces cerevisiae)
Ghost homologue of SMG8 [cytosol]
(Schizosaccharomyces pombe)
Homologues of SMG8 [cytosol]
(Sus scrofa)
LOC110258923 [cytosol]
(Sus scrofa)
smg-8 [cytosol]
(Caenorhabditis elegans)
Smg8 [cytosol]
(Mus musculus)
Smg8 [cytosol]
(Rattus norvegicus)
smg8 [cytosol]
(Xenopus tropicalis)
SMG8 [cytosol]
(Bos taurus)
SMG8 [cytosol]
(Canis familiaris)
SMG8 [cytosol]
(Dictyostelium discoideum)
SMG8 [cytosol]
(Drosophila melanogaster)
SMG8 [cytosol]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000543872
,
ENSG00000167447
,
ENSP00000300917
,
ENST00000300917
,
ENSP00000438748
,
ENSP00000462119
,
ENST00000578922
OpenTargets
ENSG00000167447
GeneCards
SMG8
HPA
ENSG00000167447-SMG8
PRO
Q8ND04
Pharos - Targets
Q8ND04
GlyGen
Q8ND04
PDB
6SYT
,
6Z3R
,
6L54
,
7PW8
,
7PW4
,
7PW5
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