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DIAPH3 [cytosol]
Stable Identifier
R-HSA-5666125
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein diaphanous homolog 3, mDia2, DRF3
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes (Homo sapiens)
DIAPH1,DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOB:GTP:DIAPH1,DIAPH3 [endosome membrane] (Homo sapiens)
DIAPH1,DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 binds effectors at the plasma membrane (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
CDC42:GTP:CDC42 effectors [plasma membrane] (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RAC2 GTPase cycle (Homo sapiens)
RAC2 binds effectors at the plasma membrane (Homo sapiens)
RAC2 plasma membrane effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Homo sapiens)
RAC2 plasma membrane effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RAC3 GTPase cycle (Homo sapiens)
RAC3 binds effectors at the plasma membrane (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RAC3:GTP:RAC3 effectors [plasma membrane] (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA binds effectors at the plasma membrane (Homo sapiens)
RHOA plasma membrane effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOA:GTP:cytosolic RHOA effectors [plasma membrane] (Homo sapiens)
RHOA plasma membrane effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB binds effectors at the plasma membrane (Homo sapiens)
RHOB effectors (plasma membrane) [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOB:GTP:cytosolic RHOB effectors [plasma membrane] (Homo sapiens)
RHOB effectors (plasma membrane) [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOB binds effectors on endosomes (Homo sapiens)
RHOB endosome effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOB:GTP:RHOB endosome effectors [endosome membrane] (Homo sapiens)
RHOB endosome effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
RHOC binds effectors at the plasma membrane (Homo sapiens)
RHOC effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOC:GTP:RHOC effectors [plasma membrane] (Homo sapiens)
RHOC effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOD GTPase cycle (Homo sapiens)
RHOD binds effectors at the plasma membrane (Homo sapiens)
RHOD plasma membrane effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOD:GTP:RHOD plasma membrane effectors [plasma membrane] (Homo sapiens)
RHOD plasma membrane effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOF GTPase cycle (Homo sapiens)
RHOF binds effectors at the plasma membrane (Homo sapiens)
RHOF effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOF:GTP:RHOF effectors [plasma membrane] (Homo sapiens)
RHOF effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOG GTPase cycle (Homo sapiens)
RHOG binds effectors at the plasma membrane (Homo sapiens)
RHOG plasma membrane effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Homo sapiens)
RHOG plasma membrane effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOJ GTPase cycle (Homo sapiens)
RHOJ binds effectors at the plasma membrane (Homo sapiens)
RHOJ effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOJ:GTP:RHOJ effectors [plasma membrane] (Homo sapiens)
RHOJ effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOQ GTPase cycle (Homo sapiens)
RHOQ binds effectors at the plasma membrane (Homo sapiens)
RHOQ effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
RHOQ:GTP:RHOQ effectors [plasma membrane] (Homo sapiens)
RHOQ effectors [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
DIAPH3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NSV4 DIAPH3
Gene Names
DIAPH3, DIAP3
Chain
chain:1-1193
Reference Genes
BioGPS Gene:81624 DIAPH3
COSMIC (genes):DIAPH3 DIAPH3
CTD Gene:81624 DIAPH3
dbSNP Gene:81624 DIAPH3
ENSEMBL:ENSG00000139734 DIAPH3
HGNC:15480 DIAPH3
KEGG:hsa:81624 DIAPH3
Monarch:81624 DIAPH3
NCBI Gene:81624 DIAPH3
OMIM:614567 DIAPH3
UCSC:Q9NSV4 DIAPH3
Reference Transcript
RefSeq:NM_001258366.1 DIAPH3
RefSeq:NM_001258369.1 DIAPH3
RefSeq:NM_001258368.1 DIAPH3
RefSeq:NM_001258370.1 DIAPH3
RefSeq:NM_001258367.1 DIAPH3
RefSeq:NM_001042517.1 DIAPH3
RefSeq:NM_030932.3 DIAPH3
Other Identifiers
11728054_a_at
11752028_a_at
16779546
220997_PM_s_at
220997_s_at
229097_PM_at
229097_at
232596_PM_at
232596_at
241719_PM_at
3515959
3515961
3515962
3515966
3515967
3515975
3515976
3515979
3515984
3515985
3515988
3515995
3515998
3515999
3516001
3516002
3516003
3516004
3516006
3516007
3516010
3516014
3516015
3516016
3516028
3516029
3516030
3516031
3516032
3516033
3516034
3516035
3516037
3516038
3516041
3516042
3516043
3516044
3516045
3516050
3516051
3516060
3516065
3516071
3516073
3516074
3516075
57771_at
66463_at
7971866
81624
A_23_P162719
A_23_P419254
A_32_P150891
A_32_P64919
GE83199
GO:0000226
GO:0000813
GO:0000922
GO:0001701
GO:0003779
GO:0005634
GO:0005737
GO:0005815
GO:0005829
GO:0005884
GO:0007010
GO:0007015
GO:0007026
GO:0007059
GO:0007163
GO:0007229
GO:0007605
GO:0008017
GO:0008092
GO:0010467
GO:0016043
GO:0016192
GO:0016197
GO:0030010
GO:0030030
GO:0030036
GO:0030041
GO:0030154
GO:0030182
GO:0030218
GO:0030225
GO:0031267
GO:0031941
GO:0032154
GO:0032432
GO:0034367
GO:0042803
GO:0043131
GO:0043226
GO:0045010
GO:0045296
GO:0046785
GO:0048856
GO:0050877
GO:0051017
GO:0051764
GO:0060113
GO:0060322
GO:0061024
GO:0061909
GO:0065003
GO:0071800
GO:0097470
GO:1990427
HMNXSV003035912
HMNXSV003055986
Hs.122164.0.S1_3p_at
Hs.283127.0.S1_3p_at
ILMN_1695226
ILMN_1874530
ILMN_2275533
ILMN_2373689
PH_hs_0006831
PH_hs_0007809
PH_hs_0014612
TC13000701.hg
TC13001533.hg
TC13001534.hg
g13569894_3p_s_at
Participates
as a candidate of
RAC1 effectors [cytosol] (Homo sapiens)
RHOB effectors (plasma membrane) [cytosol] (Homo sapiens)
as a member of
RHOB endosome effectors [cytosol] (Homo sapiens)
as a component of
DIAPH3 [cytosol] (Homo sapiens)
Inferred To
Diaph3 [cytosol]
(Mus musculus)
Diaph3 [cytosol]
(Rattus norvegicus)
dia [cytosol]
(Drosophila melanogaster)
DIAPH3 [cytosol]
(Bos taurus)
DIAPH3 [cytosol]
(Canis familiaris)
DIAPH3 [cytosol]
(Gallus gallus)
DIAPH3 [cytosol]
(Sus scrofa)
cyk-1 [cytosol]
(Caenorhabditis elegans)
Cross References
OpenTargets
ENSG00000139734
ENSEMBL
ENSP00000383174
,
ENSP00000383173
,
ENST00000400324
,
ENST00000498416
,
ENST00000377908
,
ENST00000400319
,
ENSG00000139734
,
ENSP00000267215
,
ENSP00000479091
,
ENSP00000367141
,
ENST00000465066
,
ENST00000400320
,
ENSP00000383178
,
ENSP00000478137
,
ENST00000267215
HPA
ENSG00000139734-DIAPH3
GeneCards
DIAPH3
PRO
Q9NSV4
Pharos - Targets
Q9NSV4
Orphanet
DIAPH3
GlyGen
Q9NSV4
PDB
5UWP
,
6X2Y
HMDB Protein
HMDBP08346
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6UWR7 ENPP6
1
ENPP6 [plasma membrane]
(R-HSA-6814799)
0.527
2
UniProt:P06276 BCHE
2
BCHE [plasma membrane]
(R-HSA-3640835)
BCHE [extracellular region]
(R-HSA-434469)
0.527
2
UniProt:P21709 EPHA1
2
p-Y599,Y605-EPHA1 [plasma membrane]
(R-HSA-3928336)
EPHA1 [plasma membrane]
(R-HSA-211415)
0.527
2
UniProt:Q7LGA3 HS2ST1
1
HS2ST1 [Golgi membrane]
(R-HSA-2076393)
0.527
2
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