Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
KNTC1 [cytosol]
Stable Identifier
R-HSA-376233
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Rod/KNTC1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
RZZ complex [cytosol] (Homo sapiens)
KNTC1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P50748 KNTC1
Gene Names
KNTC1, KIAA0166, ROD
Chain
chain:1-2209
Reference Genes
BioGPS Gene:9735 KNTC1
COSMIC (genes):KNTC1 KNTC1
CTD Gene:9735 KNTC1
dbSNP Gene:9735 KNTC1
ENSEMBL:ENSG00000184445 KNTC1
HGNC:17255 KNTC1
KEGG:hsa:9735 KNTC1
Monarch:9735 KNTC1
NCBI Gene:9735 KNTC1
OMIM:607363 KNTC1
UCSC:P50748 KNTC1
Reference Transcript
RefSeq:NM_014708.4 KNTC1
RefSeq:XM_006719706.2 KNTC1
Other Identifiers
11722120_a_at
16758336
206316_PM_s_at
206316_s_at
3248760
3435363
3435364
3435365
3435366
3435367
3435368
3435369
3435371
3435373
3435375
3435376
3435377
3435378
3435379
3435380
3435381
3435382
3435384
3435386
3435387
3435388
3435389
3435390
3435391
3435392
3435393
3435394
3435395
3435396
3435397
3435398
3435399
3435401
3435402
3435403
3435404
3435405
3435406
3435407
3435408
3435409
3435410
3435411
3435412
3435413
3435414
3435415
3435416
3435417
3435419
3435420
3435421
3435422
3435423
3435424
3435425
3435426
3435427
3435428
3435429
3435430
3435431
3435432
3435433
3435434
3435435
3435436
3435437
3435438
3435439
3435440
3435441
3435442
3435443
3435444
3435445
3435446
3435447
3435448
3435449
3435451
3435452
3435454
3435455
3435456
37469_at
7959408
85306_at
9735
A_23_P136817
D79988_at
GE57308
GO:0000070
GO:0000775
GO:0000776
GO:0000922
GO:0005515
GO:0005634
GO:0005694
GO:0005737
GO:0005819
GO:0005828
GO:0005829
GO:0005856
GO:0005886
GO:0007059
GO:0007094
GO:0007096
GO:0015629
GO:0031267
GO:0043226
GO:0051301
GO:0051988
GO:0065003
GO:1903394
GO:1990423
HMNXSV003016491
HMNXSV003038202
ILMN_1732516
PH_hs_0023600
TC12000974.hg
TC12002626.hg
g7661959_3p_s_at
Participates
as a component of
RZZ complex [cytosol] (Homo sapiens)
Inferred To
Kntc1 [cytosol]
(Mus musculus)
Kntc1 [cytosol]
(Rattus norvegicus)
KNTC1 [cytosol]
(Bos taurus)
KNTC1 [cytosol]
(Canis familiaris)
KNTC1 [cytosol]
(Sus scrofa)
Ghost homologue of KNTC1 [cytosol]
(Gallus gallus)
Ghost homologue of KNTC1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_055523.1
,
XP_006719769.1
ENSEMBL
ENSP00000328236
,
ENST00000333479
OpenTargets
ENSG00000184445
HPA
ENSG00000184445-KNTC1
PRO
P50748
Pharos - Targets
P50748
PDB
7QPG
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P46059 SLC15A1
1
SLC15A1 [plasma membrane]
(R-HSA-428022)
0.527
2
UniProt:P21709 EPHA1
2
p-Y599,Y605-EPHA1 [plasma membrane]
(R-HSA-3928336)
EPHA1 [plasma membrane]
(R-HSA-211415)
0.527
2
UniProt:P08173 CHRM4
1
CHRM4 [plasma membrane]
(R-HSA-390693)
0.527
2
UniProt:Q14627 IL13RA2
1
IL13RA2 [extracellular region]
(R-HSA-449666)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
