GSDME(1-270) R48I [cytosol]

Stable Identifier
R-HSA-9710474
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Gasdermin-E (1-270) R48I, Gasdermin-E, N-terminal
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
32188940 Gasdermin E suppresses tumour growth by activating anti-tumour immunity

Mok, TMY, Sengupta, S, Li, S, Meza-Sosa, KF, Junqueira, C, Zhang, Y, Ansara, J, Zhang, Z, Liu, X, Lieberman, J, Wu, H, Yao, Y, Kong, Q, Xia, S

Nature 2020
External Reference Information
External Reference
UniProt:O60443 GSDME
Gene Names
GSDME, DFNA5, ICERE1
Chain
chain:1-496, chain:1-270, chain:271-496
Reference Genes
BioGPS Gene:1687 GSDME
COSMIC (genes):GSDME GSDME
CTD Gene:1687 GSDME
dbSNP Gene:1687 GSDME
ENSEMBL:ENSG00000105928 GSDME
HGNC:2810 GSDME
KEGG:hsa:1687 GSDME
Monarch:1687 GSDME
NCBI Gene:1687 GSDME
OMIM:608798 GSDME
UCSC:O60443 GSDME
Reference Transcript
Other Identifiers
11719194_a_at
1687
17055910
203695_PM_s_at
203695_s_at
3041817
3041818
3041819
3041820
3041825
3041826
3041827
3041828
3041829
3041831
3041832
3041833
3041834
3041835
3041836
3041837
3041838
3041839
3041840
3041841
3041842
3041843
3041844
3041845
3041847
3041848
3041849
3041850
3041859
3041860
3041861
3041864
3041865
3041866
41872_at
8138602
A_23_P82449
A_33_P3221293
GE54686
GO:0002839
GO:0005215
GO:0005515
GO:0005546
GO:0005737
GO:0005829
GO:0005886
GO:0007605
GO:0008285
GO:0008289
GO:0012501
GO:0016020
GO:0022829
GO:0030154
GO:0042491
GO:0043410
GO:0050877
GO:0055085
GO:0070269
GO:0071356
GO:0098586
GO:0141201
GO:1901612
GO:2001244
HMNXSV003001929
HMNXSV003019197
ILMN_1670145
PH_hs_0023638
g4758153_3p_a_at
Participates
as a member of
Other forms of this molecule
GSDME(1-270) [cytosol]
GSDME [cytosol]
GSDME (271-496) [cytosol]
GSDME(1-270) E177V [cytosol]
GSDME(1-270) T196M [cytosol]
GSDME(1-270) G17D [cytosol]
GSDME(1-270) E134A [cytosol]
GSDME(1-270) N24D [cytosol]
GSDME E210* [cytosol]
GSDME(1-270) I217N [cytosol]
GSDME(1-270) W44C [cytosol]
GSDME(1-270) P212L [cytosol]
GSDME(1-270) D14Y [cytosol]
GSDME(1-270) D18V [cytosol]
GSDME W46* [cytosol]
GSDME(1-270) I137T [cytosol]
GSDME(1-270) G199E [cytosol]
Modified Residues
Name
L-arginine 48 replaced with L-isoleucine
Coordinate
48
PsiMod
L-arginine removal [MOD:01632]
A protein modification that effectively removes or replaces an L-arginine.
L-isoleucine residue [MOD:00019]
A protein modification that effectively converts a source amino acid residue to an L-isoleucine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
OpenTargets
ENSEMBL
HPA
PRO
Pharos - Targets
GlyGen
Interactors (8)
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