Reactome | LTN1 [cytosol]

LTN1 [cytosol]

Stable Identifier

R-HSA-5688967

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase listerin ecNumber6.3.2.-/ecNumber, LTN1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O94822 LTN1

Gene Names

LTN1, C21orf10, C21orf98, KIAA0714, RNF160, ZNF294, HSPC087

Chain

chain:1-1766

Reference Genes

BioGPS Gene:26046 LTN1

COSMIC (genes):LTN1 LTN1

CTD Gene:26046 LTN1

dbSNP Gene:26046 LTN1

ENSEMBL:ENSG00000198862 LTN1

ENSEMBL_homo_sapiens_GENE:ENSG00000198862.14 LTN1

ENSEMBL_homo_sapiens_GENE:ENSG00000291534.1 LTN1

HGNC:13082 LTN1

Monarch:26046 LTN1

NCBI Gene:26046 LTN1

OMIM:613083 LTN1

UCSC:O94822 LTN1

Reference Transcript

Other Identifiers

11724925_at

11724926_at

16924668

215596_PM_s_at

215596_s_at

233819_PM_s_at

233819_s_at

26046

39005_s_at

3927956

3927957

3927958

3927959

3927960

3927961

3927962

3927963

3927964

3927966

3927967

3927968

3927973

3927974

3927975

3927977

3927978

3927979

3927980

3927981

3927982

3927984

3927985

3927986

3927987

3927988

3927989

3927991

3927993

3927994

3928000

3928001

3928002

3928003

3928005

3928006

3928008

3928009

3928010

3928011

3928012

3928013

3928014

3928015

3928019

3928020

3928021

8069711

A_32_P115505

GE53438

GO:0003824

GO:0004842

GO:0005515

GO:0005737

GO:0005829

GO:0005840

GO:0008270

GO:0016567

GO:0016740

GO:0019538

GO:0022626

GO:0030163

GO:0036211

GO:0043023

GO:0043226

GO:0046872

GO:0051865

GO:0061630

GO:0072344

GO:0140096

GO:1990112

GO:1990116

HMNXSV003043140

Hs.288773.1.S1_3p_a_at

Hs.288773.2.S1_3p_a_at

ILMN_1760360

ILMN_2077504

PH_hs_0014996

TC21000351.hg

Participates

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

ltn1 [cytosol] (Xenopus tropicalis)

rkr1 [cytosol] (Schizosaccharomyces pombe)

RKR1 [cytosol] (Saccharomyces cerevisiae)

Ltn1 [cytosol] (Drosophila melanogaster)

Ltn1 [cytosol] (Mus musculus)

Ltn1 [cytosol] (Rattus norvegicus)

LTN1 [cytosol] (Bos taurus)

LTN1 [cytosol] (Caenorhabditis elegans)

LTN1 [cytosol] (Canis familiaris)

LTN1 [cytosol] (Gallus gallus)

LTN1 [cytosol] (Sus scrofa)

rnf160 [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_056380.2, NP_001307695.1

OpenTargets

ENSG00000198862

IntEnz

2.3.2.27

GeneCards

O94822

HPA

ENSG00000198862-LTN1

Ensembl

ENSP00000354977, ENST00000361371, ENSP00000478783, ENSG00000198862, ENST00000389194, ENSP00000373846, ENST00000614971

PRO

O94822

Pharos - Targets

O94822

PDB

3J92

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27361 MAPK3	6	MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [nucleoplasm] (R-HSA-73724) MAPK3 [cytosol] (R-HSA-59284) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359)	0.527	2
UniProt:Q9Y5B0 CTDP1	1	CTDP1 [nucleoplasm] (R-HSA-113416)	0.527	2
UniProt:P58753 TIRAP	2	TIRAP [cytosol] (R-HSA-166141) p-4Y-TIRAP [plasma membrane] (R-HSA-2201321)	0.499	2
UniProt:Q92985 IRF7	5	K63polyUb-IRF7 [endosome membrane] (R-HSA-975154) IRF7 [endosome membrane] (R-HSA-450274) p-S477,S479-IRF7 [nucleoplasm] (R-HSA-450270) p-S477,S479-IRF7 [cytosol] (R-HSA-450318) IRF7 [cytosol] (R-HSA-450281)	0.499	2
UniProt:Q86WV6 STING1	5	K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) TMEM173 [plasma membrane] (R-HSA-6804815) TMEM173 [secretory granule membrane] (R-HSA-6804798) STING [endoplasmic reticulum membrane] (R-HSA-1834940)	0.499	2