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LTN1 [cytosol]
Stable Identifier
R-HSA-5688967
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase listerin ecNumber6.3.2.-/ecNumber, LTN1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LTN1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LTN1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LTN1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LTN1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LTN1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LTN1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LTN1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LTN1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LTN1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LTN1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O94822 LTN1
Gene Names
LTN1, C21orf10, C21orf98, KIAA0714, RNF160, ZNF294, HSPC087
Chain
chain:1-1766
Reference Genes
BioGPS Gene:26046 LTN1
COSMIC (genes):LTN1 LTN1
CTD Gene:26046 LTN1
dbSNP Gene:26046 LTN1
ENSEMBL:ENSG00000198862 LTN1
HGNC:13082 LTN1
KEGG Gene (Homo sapiens):26046 LTN1
Monarch:26046 LTN1
NCBI Gene:26046 LTN1
OMIM:613083 LTN1
UCSC:O94822 LTN1
Reference Transcript
RefSeq:NM_001320766.1 LTN1
RefSeq:NM_015565.2 LTN1
Other Identifiers
0000050438
11724925_at
11724926_at
16924668
215596_s_at
233819_s_at
26046
39005_s_at
3927956
3927957
3927958
3927959
3927960
3927961
3927962
3927963
3927964
3927966
3927967
3927968
3927973
3927974
3927975
3927977
3927978
3927979
3927980
3927981
3927982
3927984
3927985
3927986
3927987
3927988
3927989
3927991
3927993
3927994
3928000
3928001
3928002
3928003
3928005
3928006
3928008
3928009
3928010
3928011
3928012
3928013
3928014
3928015
3928019
3928020
3928021
8069711
A_32_P115505
GE53438
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0006412
GO:0006464
GO:0008150
GO:0008270
GO:0009056
GO:0009058
GO:0016567
GO:0016740
GO:0032991
GO:0034641
GO:0043023
GO:0043161
GO:0043167
GO:0046872
GO:0051865
GO:0061630
GO:0072344
GO:1990112
GO:1990116
Hs.288773.1.S1_3p_a_at
Hs.288773.2.S1_3p_a_at
ILMN_1760360
ILMN_2077504
ILMN_3243686
PH_hs_0014996
TC21000351.hg
Participant Of
hasCandidate
E3 ligases in proteasomal degradation [cytosol]
Inferred To
ltn1 [cytosol] (Xenopus tropicalis)
rkr1 [cytosol] (Schizosaccharomyces pombe)
RKR1 [cytosol] (Saccharomyces cerevisiae)
Ltn1 [cytosol] (Drosophila melanogaster)
Ltn1 [cytosol] (Mus musculus)
Ltn1 [cytosol] (Rattus norvegicus)
LTN1 [cytosol] (Bos taurus)
LTN1 [cytosol] (Caenorhabditis elegans)
LTN1 [cytosol] (Canis familiaris)
LTN1 [cytosol] (Sus scrofa)
si:dkey-175g6.5 [cytosol] (Danio rerio)
rnf160 [cytosol] (Dictyostelium discoideum)
Cross References
RefSeq
NP_056380.2
,
NP_001307695.1
OpenTargets
ENSG00000198862
HPA
ENSG00000198862-LTN1
GeneCards
O94822
Ensembl
ENSP00000373846
,
ENST00000389194
,
ENSG00000198862
,
ENST00000614971
,
ENSP00000354977
,
ENSP00000478783
,
ENST00000361371
PRO
O94822
PDB
3J92
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P58753 TIRAP
2
p-4Y-TIRAP [plasma membrane]
(R-HSA-2201321)
TIRAP [cytosol]
(R-HSA-166141)
0.499
2
UniProt:Q92985 IRF7
5
IRF7 [endosome membrane]
(R-HSA-450274)
K63polyUb-IRF7 [endosome membrane]
(R-HSA-975154)
p-S477,S479-IRF7 [nucleoplasm]
(R-HSA-450270)
p-S477,S479-IRF7 [cytosol]
(R-HSA-450318)
IRF7 [cytosol]
(R-HSA-450281)
0.499
2
UniProt:Q86WV6 STING1
5
TMEM173 [secretory granule membrane]
(R-HSA-6804798)
TMEM173 [plasma membrane]
(R-HSA-6804815)
K63polyUb-STING [endoplasmic reticulum membrane]
(R-HSA-3134805)
K63polyUb-STING [cytoplasmic vesicle membrane]
(R-HSA-3248021)
TMEM173 [endoplasmic reticulum membrane]
(R-HSA-1834940)
0.499
2
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