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PEX2 [peroxisomal membrane]
Stable Identifier
R-HSA-8953913
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
peroxisomal membrane
Synonyms
Peroxisome biogenesis factor 2, PEX2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
Protein localization (Homo sapiens)
Class I peroxisomal membrane protein import (Homo sapiens)
PEX3:PEX19:class I PMP dissociates (Homo sapiens)
Class I Peroxisomal Membrane Proteins [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
Peroxisomal protein import (Homo sapiens)
Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Homo sapiens)
PEX5L:PEX7:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix (Homo sapiens)
PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12 (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module) (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
PEX5S,L:Cargo:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX2 [peroxisomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P28328 PEX2
Gene Names
PEX2, PAF1, PMP3, PMP35, PXMP3, RNF72
Chain
chain:1-305
Reference Genes
BioGPS Gene:5828 PEX2
COSMIC (genes):PEX2 PEX2
CTD Gene:5828 PEX2
dbSNP Gene:5828 PEX2
ENSEMBL:ENSG00000164751 PEX2
ENSEMBL_homo_sapiens_GENE:ENSG00000164751.15 PEX2
HGNC:9717 PEX2
KEGG Gene (Homo sapiens):5828 PEX2
Monarch:5828 PEX2
NCBI Gene:5828 PEX2
OMIM:170993 PEX2
UCSC:P28328 PEX2
Reference Transcript
RefSeq:NM_001172086.1 PEX2
RefSeq:NM_001172087.1 PEX2
RefSeq:NM_000318.2 PEX2
RefSeq:NM_001079867.1 PEX2
Other Identifiers
11733012_at
11733013_at
11756227_s_at
17078415
210296_PM_s_at
210296_s_at
228225_PM_at
228225_at
3141338
3141339
3141341
3141343
3141345
3141347
3141348
3141349
3141350
3141353
3141357
3141361
3141362
3141363
33265_at
57594_at
5828
66642_at
66917_at
8151436
A_23_P31702
A_32_P197976
A_33_P3351027
GE496963
GE513362
GE62897
GO:0000038
GO:0000425
GO:0003824
GO:0005215
GO:0005515
GO:0005634
GO:0005654
GO:0005777
GO:0005778
GO:0005829
GO:0006513
GO:0006629
GO:0006635
GO:0006886
GO:0006914
GO:0007031
GO:0008270
GO:0008320
GO:0015031
GO:0016020
GO:0016558
GO:0016562
GO:0016567
GO:0016593
GO:0016740
GO:0031648
GO:0034614
GO:0036211
GO:0043226
GO:0044721
GO:0046872
GO:0048147
GO:0050680
GO:0055085
GO:0061630
GO:0140096
GO:1990928
HMNXSV003013714
Hs.180612.2.A1_3p_at
ILMN_1743299
ILMN_1869432
M86852_at
PH_hs_0010687
TC08001347.hg
g13529226_3p_a_at
Participates
as a member of
Class I Peroxisomal Membrane Proteins [peroxisomal membrane] (Homo sapiens)
as a component of
PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
Other forms of this molecule
PEX2 [cytosol]
Inferred To
pex2 [peroxisomal membrane]
(Xenopus tropicalis)
PEX2 [peroxisomal membrane]
(Bos taurus)
PEX2 [peroxisomal membrane]
(Canis familiaris)
PEX2 [peroxisomal membrane]
(Gallus gallus)
PEX2 [peroxisomal membrane]
(Mus musculus)
PEX2 [peroxisomal membrane]
(Rattus norvegicus)
PEX2 [peroxisomal membrane]
(Sus scrofa)
Ghost homologue of PEX2 [peroxisomal membrane]
(Caenorhabditis elegans)
Ghost homologue of PEX2 [peroxisomal membrane]
(Dictyostelium discoideum)
Ghost homologue of PEX2 [peroxisomal membrane]
(Drosophila melanogaster)
Ghost homologue of PEX2 [peroxisomal membrane]
(Saccharomyces cerevisiae)
Ghost homologue of PEX2 [peroxisomal membrane]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_000309.1
,
NP_001165557.1
,
NP_001073336.1
,
NP_001165558.1
OpenTargets
ENSG00000164751
GeneCards
P28328
HPA
ENSG00000164751-PEX2
Ensembl
ENSP00000428638
,
ENST00000522527
,
ENST00000357039
,
ENSG00000164751
,
ENSP00000428590
,
ENSP00000349543
,
ENST00000520103
PRO
P28328
Pharos - Targets
P28328
Orphanet
15175
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40855 PEX19
1
PEX19 [cytosol]
(R-HSA-3009036)
0.59
4
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