Reactome | ABCD3 [peroxisomal membrane]

ABCD3 [peroxisomal membrane]

Stable Identifier

R-HSA-1456468

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

peroxisomal membrane

Synonyms

ATP-binding cassette sub-family D member 3, ABCD3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P28288 ABCD3

Gene Names

ABCD3, PMP70, PXMP1

Chain

chain:1-659

Reference Genes

BioGPS Gene:5825 ABCD3

COSMIC (genes):ABCD3 ABCD3

CTD Gene:5825 ABCD3

dbSNP Gene:5825 ABCD3

ENSEMBL:ENSG00000117528 ABCD3

ENSEMBL:ENSG00000117528.14 ABCD3

HGNC:67 ABCD3

KEGG Gene (Homo sapiens):5825 ABCD3

Monarch:5825 ABCD3

NCBI Gene:5825 ABCD3

OMIM:170995 ABCD3

UCSC:P28288 ABCD3

Reference Transcript

Other Identifiers

11720481_s_at

11741591_at

11741592_x_at

11747617_a_at

11749150_a_at

1554878_PM_a_at

1554878_a_at

16667303

202850_PM_at

202850_at

2347503

2347504

2347516

2347517

2347520

2347521

2347522

2347525

2347526

2347527

2347529

2347531

2347533

2347534

2347535

2347536

2347537

2347538

2347539

2347540

2347541

2347542

2347547

2347551

2347553

2347554

2347562

37038_at

5825

7903119

A_14_P128113

A_23_P74794

A_24_P221154

A_33_P3307955

A_33_P3307957

GE60086

GO:0000038

GO:0000166

GO:0003824

GO:0005215

GO:0005324

GO:0005515

GO:0005524

GO:0005739

GO:0005777

GO:0005778

GO:0005782

GO:0005829

GO:0006629

GO:0006633

GO:0006635

GO:0006699

GO:0006869

GO:0007031

GO:0009410

GO:0014070

GO:0015721

GO:0015910

GO:0016020

GO:0016787

GO:0016887

GO:0042626

GO:0042760

GO:0042803

GO:0043226

GO:0043231

GO:0043621

GO:0047617

GO:0055085

GO:0140359

GO:0140657

GO:1903512

HMNXSV003042979

HMNXSV003054270

Hs2.76781.2.S1_3p_s_at

ILMN_1674032

M81182_s_at

PH_hs_0004429

TC01000872.hg

X58528_s_at

g10947125_3p_at

Participates

as a member of

Class I Peroxisomal Membrane Proteins [peroxisomal membrane] (Homo sapiens)

as a component of

Other forms of this molecule

ABCD3 [cytosol]

Inferred To

ABCD3 [peroxisomal membrane] (Bos taurus)

ABCD3 [peroxisomal membrane] (Canis familiaris)

ABCD3 [peroxisomal membrane] (Danio rerio)

ABCD3 [peroxisomal membrane] (Gallus gallus)

ABCD3 [peroxisomal membrane] (Mus musculus)

ABCD3 [peroxisomal membrane] (Rattus norvegicus)

ABCD3 [peroxisomal membrane] (Sus scrofa)

pmp-2 [peroxisomal membrane] (Caenorhabditis elegans)

abcd3 [peroxisomal membrane] (Xenopus tropicalis)

Abcd3 [peroxisomal membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001116146.1, NP_002849.1

Guide to Pharmacology - Targets

790

OpenTargets

ENSG00000117528

HPA

ENSG00000117528-ABCD3

GeneCards

P28288

Ensembl

ENST00000315713, ENSG00000117528, ENSP00000326880, ENSP00000359233, ENST00000370214

PRO

P28288

Pharos - Targets

P28288

Orphanet

24320

HMDB Protein

HMDBP12675

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40855 PEX19	1	PEX19 [cytosol] (R-HSA-3009036)	0.682	4
UniProt:P33897 ABCD1	8	ABCD1 R617C [peroxisomal membrane] (R-HSA-5685069) ABCD1 T77_L82del [peroxisomal membrane] (R-HSA-5685088) ABCD1 S606L [peroxisomal membrane] (R-HSA-5685104) ABCD1 [peroxisomal membrane] (R-HSA-382566) ABCD1 [cytosol] (R-HSA-382587) ABCD1 G277R [peroxisomal membrane] (R-HSA-5685058) ABCD1 M1V [peroxisomal membrane] (R-HSA-5685059) ABCD1 R554H [peroxisomal membrane] (R-HSA-5685072)	0.508	2
UniProt:P01116 KRAS	20	S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674814) p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674821) KRAS A146T [plasma membrane] (R-HSA-9649623) KRAS K147E [plasma membrane] (R-HSA-9651169) KRAS K147T [plasma membrane] (R-HSA-9651180) KRAS V14G [plasma membrane] (R-HSA-9651295) KRAS K147N [plasma membrane] (R-HSA-9651177) KRAS A146V [plasma membrane] (R-HSA-9649626) KRAS A146S [plasma membrane] (R-HSA-9649621) KRAS A146P [plasma membrane] (R-HSA-9649617) KRAS P34R [plasma membrane] (R-HSA-9651276) KRAS P34L [plasma membrane] (R-HSA-9651269) KRAS G12A [plasma membrane] (R-HSA-9649088) KRAS G12R [plasma membrane] (R-HSA-9649090) KRAS G13V [plasma membrane] (R-HSA-9649644) KRAS G13S [plasma membrane] (R-HSA-9649642) KRAS G13C [plasma membrane] (R-HSA-9649636) KRAS G13R [plasma membrane] (R-HSA-9649639) KRAS G13A [plasma membrane] (R-HSA-9649632) KRAS K5N [plasma membrane] (R-HSA-9651361)	0.483	2

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