Reactome | PEX3:PEX19:class I PMP dissociates

PEX3:PEX19:class I PMP dissociates

Stable Identifier

R-HSA-9603775

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

peroxisomal membrane

ReviewStatus

5/5

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The PEX19:PEX3:peroxisomal membrane protein complex dissociates, yielding cytosolic PEX19, membrane-bound PEX3, and the peroxisomal membrane protein inserted in the peroxisomal membrane (Fang et al. 2004, Matsuzono and Fujiki 2006, Schueller et al. 2010, Chen et al. 2014, reviewed in Fujiki et al. 2006). The mechanism of the reaction is not fully characterized. One current model posits the transfer of the peroxisomal membrane protein from a hydrophobic region of PEX19 to a hydrophobic region of PEX3 followed by intervention in the membrane layer to release the peroxisomal membrane protein into the membrane bilayer (Chen et al. 2014). An amphipathic helical segment in the N-terminal region of PEX19 may compete with the peroxisomal membrane protein for a binding site in the C-terminal region of PEX19 and thereby participate in the release of the peroxisomal membrane protein from PEX19 (Schueller et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20531392	The peroxisomal receptor Pex19p forms a helical mPTS recognition domain Milewski, M, Schliebs, W, Wilmanns, M, Wolf, J, Konarev, P, Song, YH, Fodor, K, Holton, SJ, Schueller, N, Erdmann, R, Stanley, WA	EMBO J.	2010
15007061	PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins Fang, Y, Jones, JM, Gould, SJ, Morrell, JC	J Cell Biol	2004
17069900	Import of peroxisomal membrane proteins: the interplay of Pex3p- and Pex19p-mediated interactions Matsuzaki, T, Matsuzono, Y, Fransen, M, Fujiki, Y	Biochim. Biophys. Acta	2006
25517356	Hydrophobic handoff for direct delivery of peroxisome tail-anchored proteins Yang, J, Jedd, G, Chen, Y, Wong, JY, Pieuchot, L, Loh, RA, Kari, TM	Nat Commun	2014
16280322	In vitro transport of membrane proteins to peroxisomes by shuttling receptor Pex19p Matsuzono, Y, Fujiki, Y	J. Biol. Chem.	2006