Reactome | PEX-19 docks ABCD1/D2/D3 to peroximal membrane

PEX-19 docks ABCD1/D2/D3 to peroximal membrane

Stable Identifier

R-HSA-382613

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

peroxisomal membrane, cytosol

ReviewStatus

5/5

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PEX-19 docks ABCD1/D2/D3 to peroximal membrane

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PEX19 is a chaperone protein that binds a broad spectrum of peroxisomal membrane proteins (PMPs), and interacts with regions of PMPs required for their targeting to peroxisomes. PEX3 is required for PEX19 to dock at peroxisomes, interacts specifically with the docking domain of PEX19, and is required for recruitment of the PEX19 docking domain to peroxisomes. The ABC transporters D1, D2 and D3 must first form dimers to become fully functional (Liu et al.1999) which then can bind with PEX19.

Literature References

PubMed ID	Title	Journal	Year
9345306	cDNA cloning and mRNA expression of the human adrenoleukodystrophy related protein (ALDRP), a peroxisomal ABC transporter Holzinger, A, Kammerer, S, Berger, J, Roscher, AA	Biochem Biophys Res Commun	1997
15007061	PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins Fang, Y, Morrell, JC, Jones, JM, Gould, SJ	J Cell Biol	2004
10777694	Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p Gloeckner, CJ, Mayerhofer, PU, Landgraf, P, Muntau, AC, Holzinger, A, Gerber, JK, Kammerer, S, Adamski, J, Roscher, AA	Biochem Biophys Res Commun	2000
10704444	PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis Sacksteder, KA, Jones, JM, South, ST, Li, X, Liu, Y, Gould, SJ	J Cell Biol	2000
10551832	Homo- and heterodimerization of peroxisomal ATP-binding cassette half-transporters Liu, LX, Janvier, K, Berteaux-Lecellier, V, Cartier, N, Benarous, R, Aubourg, P	J Biol Chem	1999