PEX-19 docks ABCD1/D2/D3 to peroximal membrane

Stable Identifier
Reaction [dissociation]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PEX19 is a chaperone protein that binds a broad spectrum of peroxisomal membrane proteins (PMPs), and interacts with regions of PMPs required for their targeting to peroxisomes. PEX3 is required for PEX19 to dock at peroxisomes, interacts specifically with the docking domain of PEX19, and is required for recruitment of the PEX19 docking domain to peroxisomes. The ABC transporters D1, D2 and D3 must first form dimers to become fully functional (Liu et al.1999) which then can bind with PEX19.

Literature References
PubMed ID Title Journal Year
9345306 cDNA cloning and mRNA expression of the human adrenoleukodystrophy related protein (ALDRP), a peroxisomal ABC transporter

Holzinger, A, Kammerer, S, Roscher, AA, Berger, J

Biochem Biophys Res Commun 1997
15007061 PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins

Fang, Y, Jones, JM, Gould, SJ, Morrell, JC

J Cell Biol 2004
10777694 Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p

Holzinger, A, Landgraf, P, Kammerer, S, Roscher, AA, Muntau, AC, Adamski, J, Gerber, JK, Mayerhofer, PU, Gloeckner, CJ

Biochem Biophys Res Commun 2000
10704444 PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis

Liu, Y, Jones, JM, Li, X, Gould, SJ, Sacksteder, KA, South, ST

J Cell Biol 2000
10551832 Homo- and heterodimerization of peroxisomal ATP-binding cassette half-transporters

Benarous, R, Berteaux-Lecellier, V, Janvier, K, Cartier, N, Liu, LX, Aubourg, P

J Biol Chem 1999
Orthologous Events
Cite Us!