PEX19 is a chaperone protein that binds a broad spectrum of peroxisomal membrane proteins (PMPs), and interacts with regions of PMPs required for their targeting to peroxisomes. PEX3 is required for PEX19 to dock at peroxisomes, interacts specifically with the docking domain of PEX19, and is required for recruitment of the PEX19 docking domain to peroxisomes. The ABC transporters D1, D2 and D3 must first form dimers to become fully functional (Liu et al.1999) which then can bind with PEX19.
Holzinger, A, Kammerer, S, Roscher, AA, Berger, J
Fang, Y, Jones, JM, Gould, SJ, Morrell, JC
Holzinger, A, Landgraf, P, Kammerer, S, Roscher, AA, Muntau, AC, Adamski, J, Gerber, JK, Mayerhofer, PU, Gloeckner, CJ
Liu, Y, Jones, JM, Li, X, Gould, SJ, Sacksteder, KA, South, ST
Benarous, R, Berteaux-Lecellier, V, Janvier, K, Cartier, N, Liu, LX, Aubourg, P
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