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CD274 [plasma membrane]
Stable Identifier
R-HSA-3211776
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Programmed cell death 1 ligand 1, PD1L1_HUMAN, B7-H1
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
PD-1 signaling (Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
CD274 [plasma membrane] (Homo sapiens)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Homo sapiens)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
CD274 [plasma membrane] (Homo sapiens)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
CD274 [plasma membrane] (Homo sapiens)
PD-1 binds B7DC and B7H1 (Homo sapiens)
B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
CD274 [plasma membrane] (Homo sapiens)
PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
CD274 [plasma membrane] (Homo sapiens)
Phosphorylation of PD-1 (Homo sapiens)
PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
CD274 [plasma membrane] (Homo sapiens)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
CD274 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
STAT3 nuclear events downstream of ALK signaling (Homo sapiens)
CD274 gene expression downstream of ALK signaling (Homo sapiens)
CD274 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NZQ7 CD274
Gene Names
CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Chain
signal peptide:1-18, chain:19-290
Reference Genes
BioGPS Gene:29126 CD274
COSMIC (genes):CD274 CD274
CTD Gene:29126 CD274
dbSNP Gene:29126 CD274
ENSEMBL:ENSG00000120217.14 CD274
HGNC:17635 CD274
KEGG Gene (Homo sapiens):29126 CD274
Monarch:29126 CD274
NCBI Gene:29126 CD274
OMIM:605402 CD274
UCSC:Q9NZQ7 CD274
Reference Transcript
RefSeq:NM_001267706.1 CD274
RefSeq:NM_014143.3 CD274
Other Identifiers
0002940408
11728316_at
11745710_a_at
11753159_a_at
17083357
223834_PM_at
223834_at
227458_PM_at
227458_at
29126
3161089
3161090
3161091
3161092
3161097
3161100
3161103
3161104
3161106
3161107
56769_at
63332_at
8154233
A_23_P256487
A_23_P338479
A_33_P3381513
GE55952
GO:0002250
GO:0002376
GO:0002845
GO:0005515
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005856
GO:0005886
GO:0006955
GO:0007155
GO:0007165
GO:0007166
GO:0009897
GO:0009986
GO:0012501
GO:0012505
GO:0015629
GO:0016020
GO:0016021
GO:0023052
GO:0030335
GO:0031295
GO:0031410
GO:0031901
GO:0032689
GO:0032693
GO:0032733
GO:0034097
GO:0042102
GO:0042130
GO:0043226
GO:0046007
GO:0048856
GO:0048870
GO:0055038
GO:0070062
GO:0071222
GO:1901998
GO:1903556
GO:1905404
GO:2000562
GO:2001186
HMNXSV003005461
HMNXSV003047423
Hs.106149.0.A1_3p_at
ILMN_1701914
ILMN_1794040
PH_hs_0025890
TC09000037.hg
g10567621_3p_at
Participates
as an output of
CD274 gene expression downstream of ALK signaling (Homo sapiens)
as a member of
B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
Inferred To
Cd274 [plasma membrane]
(Mus musculus)
Cd274 [plasma membrane]
(Rattus norvegicus)
PDL1 [plasma membrane]
(Canis familiaris)
CD274 [plasma membrane]
(Bos taurus)
CD274 [plasma membrane]
(Gallus gallus)
CD274 [plasma membrane]
(Sus scrofa)
CD274 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_054862.1
,
NP_001254635.1
OpenTargets
ENSG00000120217
HPA
ENSG00000120217-CD274
GeneCards
Q9NZQ7
Ensembl
ENST00000381577
,
ENSP00000370985
,
ENSP00000370989
,
ENSG00000120217
,
ENST00000381573
PRO
Q9NZQ7
Pharos - Targets
Q9NZQ7
PDB
5X8M
,
7C88
,
5X8L
,
5NIU
,
6VQN
,
5O4Y
,
3BIK
,
5J8O
,
5JDS
,
5C3T
,
5JDR
,
6R3K
,
4ZQK
,
6NOJ
,
7TPS
,
6L8R
,
7CZD
,
5IUS
,
5GGT
,
5XXY
,
7OUN
,
5O45
,
5XJ4
,
5N2F
,
6NNV
,
6NP9
,
6NM8
,
5J89
,
6PV9
,
6NM7
,
5GRJ
,
3FN3
,
3BIS
,
7NLD
,
6RPG
,
7DY7
,
4Z18
,
5N2D
,
6YCR
,
7BEA
,
3SBW
,
6NOS
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P33681 CD80
1
CD80 [plasma membrane]
(R-HSA-179789)
0.876
11
UniProt:Q15116 PDCD1
2
p-Y223,Y248-PDCD1 [plasma membrane]
(R-HSA-389736)
PDCD1 [plasma membrane]
(R-HSA-197604)
0.802
17
UniProt:Q9NX76 CMTM6
3
CMTM6 [specific granule membrane]
(R-HSA-6800916)
CMTM6 [plasma membrane]
(R-HSA-6806275)
CMTM6 [azurophil granule membrane]
(R-HSA-6799141)
0.693
14
UniProt:Q9BQ51 PDCD1LG2
1
PDCD1LG2 [plasma membrane]
(R-HSA-3211774)
0.564
2
UniProt:Q8IZR5 CKLF4
0.499
3
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