Reactome | CD274 [plasma membrane]

CD274 [plasma membrane]

Stable Identifier

R-HSA-3211776

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Programmed cell death 1 ligand 1, PD1L1_HUMAN, B7-H1

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External Reference Information

External Reference

UniProt:Q9NZQ7 CD274

Gene Names

CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1

Chain

signal peptide:1-18, chain:19-290

Reference Genes

BioGPS Gene:29126 CD274

COSMIC (genes):CD274 CD274

CTD Gene:29126 CD274

dbSNP Gene:29126 CD274

ENSEMBL:ENSG00000120217 CD274

HGNC:17635 CD274

KEGG:hsa:29126 CD274

Monarch:29126 CD274

NCBI Gene:29126 CD274

OMIM:605402 CD274

UCSC:Q9NZQ7 CD274

Reference Transcript

Participates

as an output of

CD274 gene expression downstream of ALK signaling (Homo sapiens)

as a member of

B7-DC,B7-H1 [plasma membrane] (Homo sapiens)

Inferred To

Cd274 [plasma membrane] (Mus musculus)

Cd274 [plasma membrane] (Rattus norvegicus)

PDL1 [plasma membrane] (Canis familiaris)

CD274 [plasma membrane] (Gallus gallus)

CD274 [plasma membrane] (Sus scrofa)

PD-L1 [plasma membrane] (Bos taurus)

Homologues of CD274 [plasma membrane] (Gallus gallus)

PDCD1LG2 [plasma membrane] (Gallus gallus)

Cross References

OpenTargets

ENSG00000120217

ENSEMBL

ENST00000381573, ENST00000381577, ENSG00000120217, ENSP00000370989, ENSP00000370985

HPA

ENSG00000120217-CD274

GeneCards

CD274

PRO

Q9NZQ7

Pharos - Targets

Q9NZQ7

GlyGen

Q9NZQ7

PDB

5GRJ, 5X8L, 7XAD, 6NM8, 7UXO, 7UXQ, 6NP9, 7UXP, 5N2D, 3FN3, 6NNV, 5IUS, 6VQN, 7TPS, 3BIK, 6R3K, 8P1O, 7DY7, 5NIU, 4Z18, 7XYQ, 7UX5, 6NOJ, 5C3T, 5XJ4, 5O4Y, 8AOM, 5O45, 8K5N, 6YCR, 5JDR, 5XXY, 7YDS, 5X8M, 6L8R, 7XAE, 6NM7, 5GGT, 4ZQK, 8R6Q, 8OR1, 6PV9, 5J89, 7C88, 8JBA, 7VUN, 3BIS, 6RPG, 7SJQ, 8ALX, 3SBW, 7DCV, 5N2F, 7BEA, 7NLD, 8AOK, 6NOS, 7OUN, 5J8O, 5JDS, 7CZD, 8RPB

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P33681 CD80	1	CD80 [plasma membrane] (R-HSA-179789)	0.876	11
UniProt:Q15116 PDCD1	2	PDCD1 [plasma membrane] (R-HSA-197604) p-Y223,Y248-PDCD1 [plasma membrane] (R-HSA-389736)	0.802	17
UniProt:Q9NX76 CMTM6	3	CMTM6 [azurophil granule membrane] (R-HSA-6799141) CMTM6 [plasma membrane] (R-HSA-6806275) CMTM6 [specific granule membrane] (R-HSA-6800916)	0.693	14
UniProt:Q9BQ51 PDCD1LG2	1	PDCD1LG2 [plasma membrane] (R-HSA-3211774)	0.564	2
UniProt:Q8WVM7 STAG1	4	STAG1 [nucleoplasm] (R-HSA-163016) STAG1 [chromosome, centromeric region] (R-HSA-2466017) STAG1 [chromosome] (R-HSA-1638773) STAG1 [cytosol] (R-HSA-2484793)	0.527	2
UniProt:Q13535 ATR	1	ATR [nucleoplasm] (R-HSA-912443)	0.527	2
UniProt:Q13315 ATM	5	ATM [cytosol] (R-HSA-9665171) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043)	0.527	2
UniProt:O43156 TTI1			0.527	2
UniProt:Q9C0E2 XPO4			0.527	2
UniProt:Q9UPQ8 DOLK	6	DOLK [endoplasmic reticulum membrane] (R-HSA-449274) DOLK M1I [endoplasmic reticulum membrane] (R-HSA-4755593) DOLK H408D [endoplasmic reticulum membrane] (R-HSA-4755548) DOLK C99S [endoplasmic reticulum membrane] (R-HSA-4755602) DOLK W304C [endoplasmic reticulum membrane] (R-HSA-4755557) DOLK Y441S [endoplasmic reticulum membrane] (R-HSA-4755590)	0.527	2
UniProt:Q14746 COG2	2	COG2 [trans-Golgi network membrane] (R-HSA-6813863) COG2 [Golgi membrane] (R-HSA-5216080)	0.527	2
UniProt:Q8TCG1 CIP2A			0.527	2
UniProt:O75146 HIP1R	3	HIP1R [cytosol] (R-HSA-8868155) HIP1R [Golgi membrane] (R-HSA-434348) HIP1R [cytoplasmic vesicle membrane] (R-HSA-434201)	0.527	2
UniProt:Q8WTW3 COG1	2	COG1 [trans-Golgi network membrane] (R-HSA-6813862) COG1 [Golgi membrane] (R-HSA-6808721)	0.527	2
UniProt:Q96MW5 COG8	2	COG8 [trans-Golgi network membrane] (R-HSA-6813875) COG8 [Golgi membrane] (R-HSA-6808728)	0.527	2
UniProt:Q9UIA9 XPO7			0.527	2
UniProt:P83436 COG7	2	COG7 [trans-Golgi network membrane] (R-HSA-6813873) COG7 [Golgi membrane] (R-HSA-6808726)	0.527	2
UniProt:Q8N1S5 S39AB			0.527	3
UniProt:P42345 MTOR	2	MTOR [cytosol] (R-HSA-165662) MTOR [nucleoplasm] (R-HSA-5083674)	0.527	2
UniProt:O95373 IPO7			0.527	2
UniProt:Q96QU8 XPO6			0.527	2
UniProt:Q96JB2 COG3	2	COG3 [trans-Golgi network membrane] (R-HSA-6813865) COG3 [Golgi membrane] (R-HSA-5216030)	0.527	2
UniProt:O75691 UTP20	1	UTP20 [nucleoplasm] (R-HSA-6790692)	0.527	2
UniProt:Q8IZR5 CKLF4			0.499	3

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