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BCL2L11(1-131)-BRAF(397-766) fusion [cytosol]
Stable Identifier
R-HSA-6802276
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by BRAF and RAF1 fusions (Homo sapiens)
BRAF and RAF fusion mutant dimers are phosphorylated (Homo sapiens)
BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
BCL2L11-BRAF fusion dimer [cytosol] (Homo sapiens)
BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
25204415
The landscape of kinase fusions in cancer
Kim, JL
,
Schalm, S
,
Stransky, N
,
Lengauer, C
,
Cerami, E
Nat Commun
2014
External Reference Information
External Reference
UniProt:O43521 BCL2L11
Gene Names
BCL2L11, BIM
Chain
chain:1-198
Reference Genes
BioGPS Gene:10018 BCL2L11
COSMIC (genes):BCL2L11 BCL2L11
CTD Gene:10018 BCL2L11
dbSNP Gene:10018 BCL2L11
ENSEMBL:ENSG00000153094 BCL2L11
ENSEMBL_homo_sapiens_GENE:ENSG00000153094.25 BCL2L11
HGNC:994 BCL2L11
KEGG Gene (Homo sapiens):10018 BCL2L11
Monarch:10018 BCL2L11
NCBI Gene:10018 BCL2L11
OMIM:603827 BCL2L11
UCSC:O43521 BCL2L11
Reference Transcript
RefSeq:NM_001204107.1 BCL2L11
RefSeq:NM_207002.3 BCL2L11
RefSeq:NM_138623.3 BCL2L11
RefSeq:NM_001204112.1 BCL2L11
RefSeq:NM_001204106.1 BCL2L11
RefSeq:NM_001204111.1 BCL2L11
RefSeq:NM_138627.3 BCL2L11
RefSeq:NM_138622.3 BCL2L11
RefSeq:NM_138621.4 BCL2L11
RefSeq:NM_001204110.1 BCL2L11
RefSeq:NM_138626.3 BCL2L11
RefSeq:NM_001204109.1 BCL2L11
RefSeq:NM_006538.4 BCL2L11
RefSeq:NM_138625.3 BCL2L11
RefSeq:XM_005263559.2 BCL2L11
RefSeq:NM_001204108.1 BCL2L11
RefSeq:NM_001204113.1 BCL2L11
RefSeq:NM_138624.3 BCL2L11
RefSeq:NM_207003.2 BCL2L11
Other Identifiers
10018
11718078_a_at
11718079_a_at
11718080_a_at
11735894_a_at
11735895_at
11745162_s_at
11751830_a_at
11753710_x_at
11753863_s_at
11759889_a_at
11763068_at
11763069_x_at
11763147_x_at
1553088_PM_a_at
1553088_a_at
1553096_PM_s_at
1553096_s_at
1558143_PM_a_at
1558143_a_at
208536_PM_s_at
208536_s_at
222343_PM_at
222343_at
225606_PM_at
225606_at
2500276
2500278
2500279
2500280
2500281
2500290
2500291
2500297
2500300
2500301
2500303
2500305
2500306
2500307
2500308
2500309
31611_s_at
33047_at
57243_at
60188_at
60189_g_at
65960_at
8044375
A_23_P154426
A_23_P309991
A_23_P309996
A_23_P425954
A_24_P122921
A_33_P3251932
A_33_P3398526
GE87423
GE890567
GO:0001701
GO:0001776
GO:0001782
GO:0001822
GO:0002260
GO:0002262
GO:0002376
GO:0005515
GO:0005737
GO:0005739
GO:0005741
GO:0005829
GO:0005856
GO:0005874
GO:0006915
GO:0006919
GO:0007005
GO:0007127
GO:0007155
GO:0007160
GO:0007283
GO:0008017
GO:0008092
GO:0008584
GO:0008630
GO:0009791
GO:0012501
GO:0012505
GO:0016020
GO:0019901
GO:0022414
GO:0023052
GO:0030879
GO:0031334
GO:0034976
GO:0035148
GO:0042475
GO:0042981
GO:0043029
GO:0043065
GO:0043226
GO:0043231
GO:0043525
GO:0043583
GO:0045787
GO:0046620
GO:0048066
GO:0048070
GO:0048536
GO:0048538
GO:0048856
GO:0060090
GO:0061024
GO:0065003
GO:0070227
GO:0070230
GO:0070231
GO:0070234
GO:0070242
GO:0071385
GO:0090200
GO:0097136
GO:0097140
GO:0097141
GO:0097192
GO:0140013
GO:1902110
GO:1902237
GO:1902263
GO:1903896
GO:2000271
GO:2001244
HMNXSV003021983
HMNXSV003027795
HMNXSV003040151
HMNXSV003041716
HMNXSV003046787
Hs.50760.0.A1_3p_at
Hs.84063.0.S1_3p_at
Hs2.202657.5.S1_3p_s_at
Hs2.202657.7.S1_3p_s_at
Hs2.84063.1.A1_3p_s_at
ILMN_1766541
ILMN_1774997
ILMN_2359627
PH_hs_0022197
g5729739_3p_s_at
Participates
as a component of
BCL2L11-BRAF fusion dimer [cytosol] (Homo sapiens)
Other forms of this molecule
BCL2L11 [mitochondrial outer membrane]
BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol]
p-S69-BCL2L11 [cytosol]
p-BCL2L11 [mitochondrial outer membrane]
p-BCL2L11 [cytosol]
BCL2L11 [cytosol]
Modified Residues
Name
Insertion of residues 397 to 766 at 132 from UniProt:P15056 BRAF
Coordinate
132
Name
O-phospho-L-serine at 446
Coordinate
446
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name
Identifier
Synonyms
thyroid carcinoma
DOID:3963
head and neck cancer, Thyroid
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
NP_001191038.1
,
NP_001191040.1
,
NP_619527.1
,
NP_619528.1
,
NP_001191037.1
,
NP_619530.1
,
NP_619533.1
,
NP_001191042.1
,
NP_996886.1
,
NP_006529.1
,
NP_001191036.1
,
NP_619529.1
,
NP_996885.1
,
NP_001191041.1
,
NP_001191039.1
,
NP_001191035.1
,
NP_619532.1
,
NP_619531.1
,
XP_005263616.1
OpenTargets
ENSG00000153094
HPA
ENSG00000153094-BCL2L11
GeneCards
O43521
Ensembl
ENST00000439718
,
ENST00000405953
,
ENSP00000384641
,
ENSP00000403727
,
ENSP00000309226
,
ENSP00000401662
,
ENST00000452231
,
ENSP00000412892
,
ENST00000431217
,
ENST00000393256
,
ENSP00000376943
,
ENST00000433098
,
ENST00000415458
,
ENSP00000391292
,
ENST00000437029
,
ENST00000308659
,
ENST00000436733
,
ENSP00000393781
,
ENSP00000394640
,
ENSG00000153094
,
ENSP00000411137
PRO
O43521
Pharos - Targets
O43521
PDB
2NL9
,
5VX3
,
1F95
,
6VBX
,
2YQ6
,
2V6Q
,
5AGW
,
4QVF
,
3IO9
,
6UAB
,
6UA3
,
4ZIF
,
4B4S
,
6QFI
,
2YQ7
,
5C3G
,
5WOS
,
4YJ4
,
6TQQ
,
4ZIE
,
2K7W
,
5AGX
,
4UF3
,
3KJ0
,
4A1U
,
3KJ1
,
4ZIH
,
5VWW
,
8T5E
,
5VWV
,
4D2M
,
6RJP
,
3D7V
,
3KJ2
,
4A1W
,
5VX2
,
3FDL
,
6X8O
,
5VX0
,
3IO8
,
2VM6
,
5VWZ
,
5VWY
,
2WH6
,
5VWX
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07820 MCL1
1
MCL1 [cytosol]
(R-HSA-5661490)
0.948
19
UniProt:Q07812 BAX
3
BAX [cytosol]
(R-HSA-139916)
BAX activated [cytosol]
(R-HSA-139907)
BAX [mitochondrial outer membrane]
(R-HSA-139949)
0.943
22
UniProt:Q07817-1 BCL2L1
0.935
10
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.926
11
UniProt:Q92843 B2CL2
0.901
10
UniProt:Q9HD36 B2L10
0.832
11
UniProt:Q07817 BCL2L1
2
BCL2L1 [cytosol]
(R-HSA-50771)
BCL2L1 [mitochondrial outer membrane]
(R-HSA-114236)
0.826
11
UniProt:P97287 MCL1
0.796
7
UniProt:Q16548 BCL2A1
1
BCL2A1 [cytosol]
(R-HSA-9725307)
0.683
4
UniProt:P68451 PG045
0.621
4
UniProt:Q07440 B2LA1
0.609
2
UniProt:O43521 BCL2L11
7
BCL2L11 [mitochondrial outer membrane]
(R-HSA-2976674)
BCL2L11(1-131)-BRAF(397-766) fusion [cytosol]
(R-HSA-6802276)
BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol]
(R-HSA-6802519)
p-S69-BCL2L11 [cytosol]
(R-HSA-2976671)
p-BCL2L11 [mitochondrial outer membrane]
(R-HSA-3145027)
p-BCL2L11 [cytosol]
(R-HSA-140525)
BCL2L11 [cytosol]
(R-HSA-2976673)
0.589
2
UniProt:Q07813-1 BAX
0.558
7
UniProt:Q8N6Y0 USBP1
0.556
3
UniProt:P40855 PEX19
1
PEX19 [cytosol]
(R-HSA-3009036)
0.556
3
UniProt:Q13064 MKRN3
0.556
3
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
UniProt:P43364-2 MAGEA11
0.556
3
UniProt:Q86UW9 DTX2
1
DTX2 [cytosol]
(R-HSA-1604436)
0.556
3
UniProt:P07237 P4HB
3
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
0.556
3
UniProt:P03495 NS1
0.508
2
UniProt:Q92934 BAD
4
p-S99-BAD [cytosol]
(R-HSA-198335)
BAD [cytosol]
(R-HSA-50662)
BAD [mitochondrial outer membrane]
(R-HSA-114242)
p-S91-BAD [cytosol]
(R-HSA-217297)
0.499
2
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