Reactome | TUSC3 [endoplasmic reticulum membrane]

TUSC3 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9932255

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Tumor suppressor candidate 3, TUSC3_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Dengue Virus Infection (Homo sapiens)
      - Dengue Virus Genome Translation and Replication (Homo sapiens)
        
        Maturation of DENV proteins (Homo sapiens)
        
        E is N-glycosylated (Homo sapiens)
        
        OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-B [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-B Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
        
        MAGT1,TUSC3 [endoplasmic reticulum membrane] (Homo sapiens)
        
        TUSC3 [endoplasmic reticulum membrane] (Homo sapiens)
        
        Pre-NS1 folds and is N-glycosylated (Homo sapiens)
        
        OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-B [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-B Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
        
        MAGT1,TUSC3 [endoplasmic reticulum membrane] (Homo sapiens)
        
        TUSC3 [endoplasmic reticulum membrane] (Homo sapiens)
        
        pre-M is N-glycosylated (Homo sapiens)
        
        OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-B [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-B Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
        
        MAGT1,TUSC3 [endoplasmic reticulum membrane] (Homo sapiens)
        
        TUSC3 [endoplasmic reticulum membrane] (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        Late SARS-CoV-2 Infection Events (Homo sapiens)
        
        Translation of Structural Proteins (Homo sapiens)
        
        Maturation of spike protein (Homo sapiens)
        
        Spike protein gets N-glycosylated (Homo sapiens)
        
        OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-B [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-B Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
        
        MAGT1,TUSC3 [endoplasmic reticulum membrane] (Homo sapiens)
        
        TUSC3 [endoplasmic reticulum membrane] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Regulation of PD-L1(CD274) expression (Homo sapiens)
        
        Regulation of PD-L1(CD274) Post-translational modification (Homo sapiens)
        
        PD-L1(CD274) glycosylation and translocation to plasma membrane (Homo sapiens)
        
        CD274 N-linked glycosylation in ER (Homo sapiens)
        
        OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-B [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-B Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
        
        MAGT1,TUSC3 [endoplasmic reticulum membrane] (Homo sapiens)
        
        TUSC3 [endoplasmic reticulum membrane] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transfer of N-glycan to the protein (Homo sapiens)
      - OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-B [endoplasmic reticulum membrane] (Homo sapiens)
        
        OST-B Subcomplex II [endoplasmic reticulum membrane] (Homo sapiens)
        
        MAGT1,TUSC3 [endoplasmic reticulum membrane] (Homo sapiens)
        
        TUSC3 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13454 TUSC3

Gene Names

TUSC3, N33

Chain

signal peptide:1-41, chain:42-348

Reference Genes

BioGPS Gene:7991 TUSC3

COSMIC (genes):TUSC3 TUSC3

CTD Gene:7991 TUSC3

dbSNP Gene:7991 TUSC3

ENSEMBL:ENSG00000104723 TUSC3

HGNC:30242 TUSC3

KEGG:hsa:7991 TUSC3

Monarch:7991 TUSC3

NCBI Gene:7991 TUSC3

OMIM:601385 TUSC3

UCSC:Q13454 TUSC3

Reference Transcript

Other Identifiers

11743152_a_at

11754689_x_at

17065958

209227_PM_at

209227_at

209228_PM_x_at

209228_x_at

213423_PM_x_at

213423_x_at

232770_PM_at

232770_at

235801_PM_at

235801_at

3087158

3087168

3087169

3087170

3087177

3087178

3087186

3087187

3087188

3087189

3087190

3087191

3087192

3087202

3087203

3087208

3087209

3087211

3087212

3087215

3087216

3087217

3087218

3087219

3087220

3087221

3087222

3087223

3087224

3087225

3087226

3087227

3087228

3087229

3087230

36851_g_at

36852_at

76622_at

7991

80015_at

81131_at

8144726

A_14_P127766

A_24_P915908

A_24_P95154

GE657660

GE81676

GE83838

GO:0005739

GO:0005783

GO:0005789

GO:0005886

GO:0006486

GO:0006487

GO:0008250

GO:0015095

GO:0015693

GO:0016020

GO:0018279

GO:0050877

GO:0050890

GO:0055085

GO:1903830

HMNXSV003001715

HMNXSV003042442

Hs.255425.0.S1_3p_at

Hs.283526.0.A1_3p_at

Hs.71119.0.A2_3p_at

Hs.71119.1.A1_3p_a_at

ILMN_1774689

ILMN_2354547

PH_hs_0038712

TC08000119.hg

TC08001811.hg

U42359_at

U42360_cds2_at

Participates

as a member of

MAGT1,TUSC3 [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

TUSC3(1-348) [plasma membrane]

Inferred To

TUSC3 [endoplasmic reticulum membrane] (Bos taurus)

TUSC3 [endoplasmic reticulum membrane] (Canis familiaris)

TUSC3 [endoplasmic reticulum membrane] (Gallus gallus)

TUSC3 [endoplasmic reticulum membrane] (Sus scrofa)

Tusc3 [endoplasmic reticulum membrane] (Mus musculus)

Tusc3 [endoplasmic reticulum membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001400512.1, NP_001400618.1, NP_001343358.1, NP_839952.1, NP_006756.2

Guide to Pharmacology - Targets

3040

OpenTargets

ENSG00000104723

ENSEMBL

ENSG00000104723, ENST00000382020, ENST00000503731, ENSP00000424544, ENSP00000371450

HPA

ENSG00000104723-TUSC3

GeneCards

TUSC3

PRO

Q13454

Pharos - Targets

Q13454

Orphanet

TUSC3

PDB

4M8G, 4M92, 4M91, 4M90

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04844 RPN2	1	RPN2 [endoplasmic reticulum membrane] (R-HSA-264937)	0.725	5
UniProt:Q8TCJ2 STT3B	1	STT3B [endoplasmic reticulum membrane] (R-HSA-264930)	0.643	3
UniProt:P0DTD8 NS7B			0.547	2
UniProt:P40855 PEX19	1	PEX19 [cytosol] (R-HSA-3009036)	0.527	2
UniProt:Q14165 MLEC	3	MLEC [plasma membrane] (R-HSA-6806292) MLEC [specific granule membrane] (R-HSA-6799618) MLEC [endoplasmic reticulum membrane] (R-HSA-901082)	0.527	2
UniProt:Q9NZJ5 EIF2AK3	3	EIF2AK3 [endoplasmic reticulum membrane] (R-HSA-381046) EIF2AK3(30-144)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713456) EIF2AK3(30-144)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713454)	0.527	2
UniProt:P61803 DAD1	1	DAD1 [endoplasmic reticulum membrane] (R-HSA-265089)	0.527	2
UniProt:P43681 CHRNA4	1	CHRNA4 [plasma membrane] (R-HSA-507836)	0.527	2
UniProt:P39656 DDOST	3	DDOST [plasma membrane] (R-HSA-879386) DDOST [azurophil granule membrane] (R-HSA-6799145) DDOST [endoplasmic reticulum membrane] (R-HSA-264963)	0.527	2