Reactome | IFNB1 [extracellular region]

IFNB1 [extracellular region]

Stable Identifier

R-HSA-877351

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Interferon beta, IFNB_HUMAN

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - RSV-host interactions (Homo sapiens)
        
        Evasion by RSV of host interferon responses (Homo sapiens)
        
        Recruitment of STAT2 to p-IFNAR1 (Homo sapiens)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
        
        IFNB1 [extracellular region] (Homo sapiens)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Homo sapiens)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
        
        IFNB1 [extracellular region] (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        Phosphorylation of STAT1 (Homo sapiens)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Homo sapiens)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
        
        IFNB1 [extracellular region] (Homo sapiens)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Homo sapiens)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
        
        IFNB1 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01574 IFNB1

Gene Names

IFNB1, IFB, IFNB

Chain

signal peptide:1-21, chain:22-187

Reference Genes

BioGPS Gene:3456 IFNB1

COSMIC (genes):IFNB1 IFNB1

CTD Gene:3456 IFNB1

dbSNP Gene:3456 IFNB1

ENSEMBL:ENSG00000171855 IFNB1

HGNC:5434 IFNB1

KEGG:hsa:3456 IFNB1

Monarch:3456 IFNB1

NCBI Gene:3456 IFNB1

OMIM:147640 IFNB1

UCSC:P01574 IFNB1

Reference Transcript

RefSeq:NM_002176.3 IFNB1

Other Identifiers

11733765_at

1214_s_at

17092809

208173_PM_at

208173_at

3201145

3201146

3201147

3201148

3456

8160360

A_23_P71774

GO:0002250

GO:0002286

GO:0002312

GO:0002323

GO:0002376

GO:0003824

GO:0005125

GO:0005126

GO:0005132

GO:0005515

GO:0005576

GO:0005615

GO:0006355

GO:0006952

GO:0006959

GO:0007165

GO:0007166

GO:0007259

GO:0008811

GO:0009615

GO:0010508

GO:0016740

GO:0019221

GO:0030101

GO:0030154

GO:0030183

GO:0033141

GO:0035458

GO:0042100

GO:0043330

GO:0045071

GO:0045087

GO:0045089

GO:0045343

GO:0045581

GO:0045944

GO:0048018

GO:0051607

GO:0060337

GO:0070050

GO:0071360

GO:0098542

GO:0098586

GO:0098772

GO:0140123

GO:2000552

GO:2001235

HMNXSV003011302

ILMN_1682245

PH_hs_0031412

TC09000946.hg

V00535_rna2_s_at

g4504602_3p_at

Participates

as an output of

Expression of interferon-beta (Homo sapiens)

as a member of

IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)

This entity regulates

Positively

RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) (Homo sapiens)

Inferred To

Homologues of IFNB1 [extracellular region] (Danio rerio)

Homologues of IFNB1 [extracellular region] (Gallus gallus)

Ifnb1 [extracellular region] (Mus musculus)

Ifnb1 [extracellular region] (Rattus norvegicus)

IFNA2 [extracellular region] (Gallus gallus)

ifnphi4 [extracellular region] (Danio rerio)

IFNA [extracellular region] (Gallus gallus)

IFNB [extracellular region] (Gallus gallus)

ifnphi2 [extracellular region] (Danio rerio)

IFN-beta [extracellular region] (Canis familiaris)

ifnphi3 [extracellular region] (Danio rerio)

ifnphi1 [extracellular region] (Danio rerio)

IFNB1 [extracellular region] (Bos taurus)

IFNB1 [extracellular region] (Gallus gallus)

IFNB1 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_002167.1

ENSEMBL

ENST00000380232, ENSP00000369581

OpenTargets

ENSG00000171855

HPA

ENSG00000171855-IFNB1

PRO

P01574

Pharos - Targets

P01574

GlyGen

P01574

HMDB Protein

HMDBP02832

PDB

1AU1

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40855 PEX19	1	PEX19 [cytosol] (R-HSA-3009036)	0.556	3

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