Reactome | K63polyUb-polyLacNac-Glycosylated CD274 [Golgi membrane]

K63polyUb-polyLacNac-Glycosylated CD274 [Golgi membrane]

Stable Identifier

R-HSA-9931435

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NZQ7 CD274

Gene Names

CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1

Chain

signal peptide:1-18, chain:19-290

Reference Genes

BioGPS Gene:29126 CD274

COSMIC - genes:CD274 CD274

CTD Gene:29126 CD274

dbSNP Gene:29126 CD274

ENSEMBL:ENSG00000120217 CD274

HGNC:17635 CD274

KEGG:hsa:29126 CD274

Monarch:29126 CD274

NCBI Gene:29126 CD274

OMIM:605402 CD274

UCSC:Q9NZQ7 CD274

Reference Transcript

Participates

as an input of

K63-Ub-polyLacNac-Glycosylated CD274 transport to plasma membrane (Homo sapiens)

as an output of

MIB2-mediated K63-ubiquitination of CD274 (Homo sapiens)

Other forms of this molecule

p-S184,T180-CD274 [endoplasmic reticulum membrane]

p-S184,T180-CD274 [cytosol]

CD274 [endoplasmic reticulum membrane]

N-glycosylated CD274 [endoplasmic reticulum membrane]

p-T194,T210-CD274 [endoplasmic reticulum membrane]

p-S195-CD274 [endoplasmic reticulum membrane]

p-S195-CD274 [cytosol]

CD274 [cytosol]

p-T285,T290-CD274 [endoplasmic reticulum membrane]

p-Y112-CD274 [endoplasmic reticulum membrane]

polyLacNac-Glycosylated CD274 [Golgi membrane]

N-glycosylated CD274 [Golgi membrane]

CD274 [plasma membrane]

K63polyUb-polyLacNac-Glycosylated CD274 [plasma membrane]

Inferred To

CD274 [Golgi membrane] (Bos taurus)

CD274 [Golgi membrane] (Canis familiaris)

CD274 [Golgi membrane] (Gallus gallus)

CD274 [Golgi membrane] (Sus scrofa)

Cd274 [Golgi membrane] (Mus musculus)

Cd274 [Golgi membrane] (Rattus norvegicus)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [mitochondrial outer membrane]) at unknown position

Modification

K63polyUb [mitochondrial outer membrane]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001300958.1, NP_054862.1, NP_001254635.1

OpenTargets

ENSG00000120217

ENSEMBL

ENST00000381573, ENSG00000120217, ENSP00000370985, ENSP00000370989, ENST00000381577

GeneCards

CD274

HPA

ENSG00000120217-CD274

PRO

Q9NZQ7

Pharos - Targets

Q9NZQ7

GlyGen

Q9NZQ7

PDB

5JDR, 5O45, 6YCR, 7YDS, 8K5N, 5XXY, 5X8L, 6NM8, 5X8M, 5GRJ, 7XAE, 6L8R, 6NM7, 6NP9, 7UXQ, 7UXO, 6PV9, 8OR1, 4Z18, 7XYQ, 7UX5, 7BEA, 6NNV, 5N2D, 3FN3, 3BIK, 5IUS, 8XR5, 8AOK, 5NIU, 7DY7, 8P1O, 6R3K, 7NLD, 5JDS, 6NOS, 7OUN, 8RPB, 5J8O, 7CZD, 7C88, 7XAD, 5GGT, 8ZNL, 7SJQ, 6VQN, 7TPS, 5J89, 4ZQK, 7UXP, 7VUN, 5N2F, 7DCV, 8JBA, 9INU, 6RPG, 3BIS, 8R6Q, 5XJ4, 8AOM, 5O4Y, 3SBW, 8ALX, 6NOJ, 5C3T

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P33681 CD80	1	CD80 [plasma membrane] (R-HSA-179789)	0.946	15
UniProt:Q15116 PDCD1	2	PDCD1 [plasma membrane] (R-HSA-197604) p-Y223,Y248-PDCD1 [plasma membrane] (R-HSA-389736)	0.889	20
UniProt:Q9BQ51 PDCD1LG2	1	PDCD1LG2 [plasma membrane] (R-HSA-3211774)	0.743	4
UniProt:Q9NX76 CMTM6	3	CMTM6 [specific granule membrane] (R-HSA-6800916) CMTM6 [plasma membrane] (R-HSA-6806275) CMTM6 [azurophil granule membrane] (R-HSA-6799141)	0.693	14
UniProt:Q8N1S5 S39AB			0.643	4
UniProt:O75691 UTP20	1	UTP20 [nucleoplasm] (R-HSA-6790692)	0.527	2
UniProt:Q96JB2 COG3	2	COG3 [trans-Golgi network membrane] (R-HSA-6813865) COG3 [Golgi membrane] (R-HSA-5216030)	0.527	2
UniProt:Q8TCG1 CIP2A			0.527	2
UniProt:Q14746 COG2	2	COG2 [trans-Golgi network membrane] (R-HSA-6813863) COG2 [Golgi membrane] (R-HSA-5216080)	0.527	2
UniProt:O43156 TTI1			0.527	2
UniProt:Q13315 ATM	5	ATM [cytosol] (R-HSA-9665171) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043)	0.527	2
UniProt:P40855 PEX19	1	PEX19 [cytosol] (R-HSA-3009036)	0.527	2
UniProt:O95373 IPO7	1	IPO7 [nuclear envelope] (R-HSA-5216002)	0.527	2
UniProt:Q8WTW3 COG1	3	COG1 [trans-Golgi network membrane] (R-HSA-6813862) COG1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9921505) COG1 [Golgi membrane] (R-HSA-6808721)	0.527	2
UniProt:Q9UPQ8 DOLK	6	DOLK [endoplasmic reticulum membrane] (R-HSA-449274) DOLK M1I [endoplasmic reticulum membrane] (R-HSA-4755593) DOLK H408D [endoplasmic reticulum membrane] (R-HSA-4755548) DOLK C99S [endoplasmic reticulum membrane] (R-HSA-4755602) DOLK W304C [endoplasmic reticulum membrane] (R-HSA-4755557) DOLK Y441S [endoplasmic reticulum membrane] (R-HSA-4755590)	0.527	2
UniProt:Q8WVM7 STAG1	4	STAG1 [nucleoplasm] (R-HSA-163016) STAG1 [chromosome, centromeric region] (R-HSA-2466017) STAG1 [chromosome] (R-HSA-1638773) STAG1 [cytosol] (R-HSA-2484793)	0.527	2
UniProt:Q9C0E2 XPO4			0.527	2
UniProt:Q96ER3 SAAL1			0.527	3
UniProt:O75146 HIP1R	3	HIP1R [Golgi membrane] (R-HSA-434348) HIP1R [cytoplasmic vesicle membrane] (R-HSA-434201) HIP1R [cytosol] (R-HSA-8868155)	0.527	2
UniProt:Q96MW5 COG8	2	COG8 [trans-Golgi network membrane] (R-HSA-6813875) COG8 [Golgi membrane] (R-HSA-6808728)	0.527	2
UniProt:Q9UIA9 XPO7			0.527	2
UniProt:P83436 COG7	2	COG7 [trans-Golgi network membrane] (R-HSA-6813873) COG7 [Golgi membrane] (R-HSA-6808726)	0.527	2
UniProt:P42345 MTOR	2	MTOR [cytosol] (R-HSA-165662) MTOR [nucleoplasm] (R-HSA-5083674)	0.527	2
UniProt:Q96QU8 XPO6			0.527	2
UniProt:Q96JB5 CK5P3			0.527	3
UniProt:Q13535 ATR	1	ATR [nucleoplasm] (R-HSA-912443)	0.527	2
UniProt:Q8IZR5 CKLF4			0.499	3

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