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IL23A [extracellular region]
Stable Identifier
R-HSA-447245
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interleukin-23 subunit alpha, IL23A_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-23 signaling (Homo sapiens)
IL12B:IL23A translocates from ER lumen to extracellular space (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL23A [extracellular region] (Homo sapiens)
IL23R in IL23:IL23 receptor complex is phosphorylated (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL23A [extracellular region] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL23A [extracellular region] (Homo sapiens)
Interleukin-23 binds interleukin-23 receptor (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL23A [extracellular region] (Homo sapiens)
IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL23A [extracellular region] (Homo sapiens)
JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL23A [extracellular region] (Homo sapiens)
IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL23A [extracellular region] (Homo sapiens)
STAT3 binds to p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL23A [extracellular region] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL23A [extracellular region] (Homo sapiens)
STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL23A [extracellular region] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL23A [extracellular region] (Homo sapiens)
STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL23A [extracellular region] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL23A [extracellular region] (Homo sapiens)
p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL23A [extracellular region] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL12B:IL23A [extracellular region] (Homo sapiens)
IL23A [extracellular region] (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated extracellular proteins (Homo sapiens)
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
IL23A [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NPF7 IL23A
Gene Names
IL23A, SGRF, UNQ2498/PRO5798
Chain
signal peptide:1-19, chain:20-189
Reference Genes
BioGPS Gene:51561 IL23A
COSMIC (genes):IL23A IL23A
CTD Gene:51561 IL23A
dbSNP Gene:51561 IL23A
ENSEMBL:ENSG00000110944 IL23A
ENSEMBL_homo_sapiens_GENE:ENSG00000110944.9 IL23A
HGNC:15488 IL23A
KEGG Gene (Homo sapiens):51561 IL23A
Monarch:51561 IL23A
NCBI Gene:51561 IL23A
OMIM:605580 IL23A
UCSC:Q9NPF7 IL23A
Reference Transcript
RefSeq:XM_011538477.2 IL23A
RefSeq:NM_016584.2 IL23A
Other Identifiers
11732301_at
16752645
220054_PM_at
220054_at
3417561
3417563
3417564
3417565
3417566
3417567
3417568
49076_at
51561
7956251
A_23_P76078
GE53760
GO:0001916
GO:0002230
GO:0002376
GO:0002827
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0005783
GO:0005788
GO:0006351
GO:0006355
GO:0006954
GO:0006955
GO:0007155
GO:0007165
GO:0010536
GO:0023052
GO:0030154
GO:0032693
GO:0032725
GO:0032729
GO:0032733
GO:0032735
GO:0032740
GO:0032760
GO:0032816
GO:0032819
GO:0034105
GO:0036211
GO:0042098
GO:0042102
GO:0042104
GO:0042509
GO:0042531
GO:0043226
GO:0043382
GO:0045087
GO:0045519
GO:0045672
GO:0045944
GO:0048018
GO:0048771
GO:0048856
GO:0048870
GO:0050729
GO:0050829
GO:0051135
GO:0051142
GO:0051607
GO:0070743
GO:0090023
GO:0098542
GO:0098772
GO:1901224
GO:2000318
GO:2000330
HMNXSV003045248
ILMN_1715603
PH_hs_0005407
TC12000512.hg
TC12002390.hg
g7706701_3p_at
Participates
as a component of
IL12B:IL23A [extracellular region] (Homo sapiens)
as a member of
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
IL23A [endoplasmic reticulum lumen]
Inferred To
IL23A [extracellular region]
(Bos taurus)
IL23A [extracellular region]
(Canis familiaris)
IL23A [extracellular region]
(Sus scrofa)
Il23a [extracellular region]
(Mus musculus)
Il23a [extracellular region]
(Rattus norvegicus)
Ghost homologue of IL23A [extracellular region]
(Gallus gallus)
Cross References
RefSeq
NP_057668.1
,
XP_011536779.1
OpenTargets
ENSG00000110944
HPA
ENSG00000110944-IL23A
GeneCards
Q9NPF7
Ensembl
ENSP00000228534
,
ENST00000228534
,
ENSG00000110944
PRO
Q9NPF7
Pharos - Targets
Q9NPF7
PDB
6WDQ
,
6UIB
,
8OE4
,
5NJD
,
3QWR
,
5MXA
,
5MJ4
,
3D87
,
3D85
,
3DUH
,
5MZV
,
5MJ3
,
4GRW
,
8CR8
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P29460 IL12B
5
IL12B [extracellular region]
(R-HSA-447181)
IL12B [endoplasmic reticulum lumen]
(R-HSA-8950126)
IL12B [late endosome lumen]
(R-HSA-8950675)
IL12B [Golgi lumen]
(R-HSA-8950359)
IL12B [cytosol]
(R-HSA-8950760)
0.813
6
UniProt:P40855 PEX19
1
PEX19 [cytosol]
(R-HSA-3009036)
0.718
6
UniProt:Q9H4P4 RNF41
1
RNF41 [cytosol]
(R-HSA-975977)
0.527
2
UniProt:Q5VWK5 IL23R
2
p-Y-IL23R [plasma membrane]
(R-HSA-8950616)
IL23R [plasma membrane]
(R-HSA-447156)
0.525
2
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