p-8Y-FGFR1c P252T [plasma membrane]

Stable Identifier
R-HSA-2011868
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
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p-8Y-FGFR1c P252T [plasma membrane] icon
p-8Y-FGFR1c P252T [plasma membrane] icon
Locations in the PathwayBrowser
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General
thought to increase # hydrogen bonds, increase ligand affinity and ligand binding range (Ruhe 2007)
Literature References
PubMed ID Title Journal Year
21367659 Targeting mutant fibroblast growth factor receptors in cancer

Pollock, PM, Greulich, H

Trends Mol Med 2011
16140923 Somatic mutations of the protein kinase gene family in human lung cancer

Easton, DF, Dicks, E, Stratton, MR, Davies, H, Cooper, CS, Tofts, C, Teh, BT, Edkins, S, Teague, J, Pierotti, MA, Futreal, PA, Webb, A, Forbes, S, Flanagan, AM, Kosmidou, V, Lakhani, SR, Laman, R, Jones, D, Knowles, M, Hinton, J, Hunter, C, Yates, A, Greenman, C, Halliday, K, Yuen, ST, Hills, K, O'Meara, S, Perry, J, Malkowicz, B, Menzies, A, Parker, A, Nicholson, AG, Clements, J, Edwards, K, Green, A, Looijenga, LH, Harrison, R, Lugg, R, Leung, SY, Butler, A, Stephens, P, Stephens, Y, Stevens, C, Cole, J, Brackenbury, L, Small, A, Brasseur, F, Smith, R, Buck, G, Solomon, H, Raine, K, Barthorpe, S, Shepherd, R, Bignell, G, Petty, R, Avis, T, Weber, BL, West, S, Widaa, S, Goldstraw, P, Gorton, M, Gray, K, Wooster, R, Varian, J

Cancer Res 2005
External Reference Information
External Reference
UniProt:P11362-1 FGFR1
Gene Names
FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
Participates
as a component of
Other forms of this molecule
FGFR1c P252R [plasma membrane]
FGFR1c P252S [plasma membrane]
FGFR1c P252T [plasma membrane]
p-8Y-FGFR1c P252S [plasma membrane]
p-8Y-FGFR1c P252R [plasma membrane]
FGFR1c [plasma membrane]
p-8Y-FGFR1c [plasma membrane]
Inferred From
p-8Y-FGFR1c P252R [plasma membrane] (Homo sapiens)
Modified Residues
Name
L-proline 252 replaced with L-threonine
Coordinate
252
PsiMod
L-proline removal [MOD:01645]
A protein modification that effectively removes or replaces an L-proline.
L-threonine residue [MOD:00026]
A protein modification that effectively converts a source amino acid residue to L-threonine.
Name
O4'-phospho-L-tyrosine at 463
Coordinate
463
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 583
Coordinate
583
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 585
Coordinate
585
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 653
Coordinate
653
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 654
Coordinate
654
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 730
Coordinate
730
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 766
Coordinate
766
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 776
Coordinate
776
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
lung cancer DOID:1324
Interactors (25)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P09038 FGF2  1 0.912 9
 UniProt:P19174 PLCG1  6 0.903 11
 UniProt:P05230 FGF1  1 0.838 5
 UniProt:P46934 NEDD4  1 0.672 26
 UniProt:P51812 RPS6KA3  7 0.671 4
 UniProt:P08238 HSP90AB1  6 0.669 3
 UniProt:P27986 PIK3R1  16 0.644 6
 UniProt:Q8IVI9 NOSTRIN  2 0.633 5
 UniProt:P23352 ANOS1  1 0.626 7
 UniProt:P11362 FGFR1  9 0.623 4
 UniProt:P35222 CTNNB1  20 0.623 3
 UniProt:P21802 FGFR2  20 0.623 3
 UniProt:P08908 HTR1A  1 0.62 9
 UniProt:P10686 Plcg1  8 0.611 4
 UniProt:Q16543 CDC37  1 0.569 4
 UniProt:Q9NQH7 XPP3      0.569 3
 UniProt:Q8WU20 FRS2  6 0.569 3
 UniProt:O35082  2 0.558 2
 UniProt:Q9GZV9 FGF23  6 0.544 2
 UniProt:P22455 FGFR4  12 0.539 3
 UniProt:P12830 CDH1  8 0.536 3
 UniProt:Q7KZF4 SND1  2 0.483 2
 UniProt:P46108 CRK  1 0.483 2
 UniProt:P06493 CDK1  11 0.483 3
 UniProt:O88900  1 0.471 3
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