Reactome | FGF23 [endoplasmic reticulum lumen]

FGF23 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8956697

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Fibroblast growth factor 23, FGF23_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9GZV9 FGF23

Gene Names

FGF23, HYPF, UNQ3027/PRO9828

Chain

signal peptide:1-24, chain:25-251, chain:25-179, chain:180-251

Reference Genes

BioGPS Gene:8074 FGF23

COSMIC (genes):FGF23 FGF23

CTD Gene:8074 FGF23

dbSNP Gene:8074 FGF23

ENSEMBL:ENSG00000118972 FGF23

HGNC:3680 FGF23

KEGG:hsa:8074 FGF23

Monarch:8074 FGF23

NCBI Gene:8074 FGF23

OMIM:605380 FGF23

UCSC:Q9GZV9 FGF23

Reference Transcript

RefSeq:NM_020638.2 FGF23

Other Identifiers

11738379_at

11738380_at

11738381_at

16760148

221166_PM_at

221166_at

3441169

3441170

3441171

3441172

3441173

3441174

3441175

7960397

8074

A_23_P117095

GE82551

GO:0000165

GO:0005104

GO:0005105

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005788

GO:0005796

GO:0006355

GO:0006629

GO:0006766

GO:0008083

GO:0008284

GO:0008543

GO:0009887

GO:0010628

GO:0010966

GO:0010980

GO:0030154

GO:0030334

GO:0030500

GO:0030502

GO:0030643

GO:0032026

GO:0042359

GO:0042369

GO:0043410

GO:0044320

GO:0045668

GO:0045893

GO:0046888

GO:0048018

GO:0055062

GO:0055074

GO:0070371

GO:0070374

GO:0071305

GO:0071354

GO:0071374

GO:0090080

GO:0098772

GO:1904383

HMNXSV003016648

ILMN_1696488

ILMN_1869676

ILMN_2071316

PH_hs_0014821

TC12001120.hg

g10190673_3p_at

Participates

as a member of

FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

p-FGF23 [endoplasmic reticulum lumen]

FGF23(25-251) [Golgi lumen]

GalNAc-T178-FGF23(25-251) [Golgi lumen]

FGF23(25-251) [extracellular region]

GalNAc-T178-FGF23(25-251) [extracellular region]

Inferred To

fgf23 [endoplasmic reticulum lumen] (Xenopus tropicalis)

FGF8B [endoplasmic reticulum lumen] (Canis familiaris)

Homologues of FGF23 [endoplasmic reticulum lumen] (Xenopus tropicalis)

bnl [endoplasmic reticulum lumen] (Drosophila melanogaster)

fgf23.2 [endoplasmic reticulum lumen] (Xenopus tropicalis)

FGF23 [endoplasmic reticulum lumen] (Bos taurus)

FGF23 [endoplasmic reticulum lumen] (Gallus gallus)

FGF23 [endoplasmic reticulum lumen] (Sus scrofa)

Fgf23 [endoplasmic reticulum lumen] (Mus musculus)

Fgf23 [endoplasmic reticulum lumen] (Rattus norvegicus)

egl-17 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

Cross References

RefSeq

NP_065689.1

ENSEMBL

ENSP00000237837, ENST00000237837

OpenTargets

ENSG00000118972

HPA

ENSG00000118972-FGF23

PRO

Q9GZV9

Pharos - Targets

Q9GZV9

GlyGen

Q9GZV9

Orphanet

FGF23

HMDB Protein

HMDBP02741

PDB

6S22, 7YSU, 7YSW, 7YSH, 2P39, 5W21

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O35082	2	Kl [plasma membrane] (R-MMU-190198) Kl [extracellular region] (R-MMU-190201)	0.733	5
UniProt:P11362 FGFR1	9	FGFR1 [plasma membrane] (R-HSA-9756433) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) FGFR1 R576W [plasma membrane] (R-HSA-2011844) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241)	0.544	2