Reactome | FGFR1c P252S [plasma membrane]

FGFR1c P252S [plasma membrane]

Stable Identifier

R-HSA-1614383

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

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General

thought to increase # hydrogen bonds, increase ligand affinity and ligand binding range (Ruhe 2007)

Literature References

PubMed ID	Title	Journal	Year
18056464	Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines Tay, LS, Streit, S, Lee, TC, Ullrich, A, Loo, HL, Lim, SJ, Venkatesh, B, Foo, P, Mann, C, Luo, M, Peng, K, Wong, CH, Ong, H, Wong, W, Gaertner, S, Tay, A, Pok, S, Hart, S, Peter, S, Hoefler, H, Bezler, M, Ruhe, JE, Ho, HK, Knyazev, P, Iacobelli, S, Brenner, S, Knyazeva, T, Specht, K	Cancer Res	2007

External Reference Information

External Reference

UniProt:P11362-1 FGFR1

Gene Names

FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR

Participates

as a member of

FGFR1c P252X mutants [plasma membrane] (Homo sapiens)

as a component of

FGFR1c P252S mutant dimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

FGFR1c P252R [plasma membrane]

FGFR1c P252T [plasma membrane]

p-8Y-FGFR1c P252S [plasma membrane]

p-8Y-FGFR1c P252T [plasma membrane]

p-8Y-FGFR1c P252R [plasma membrane]

FGFR1c [plasma membrane]

p-8Y-FGFR1c [plasma membrane]

Modified Residues

Name

L-proline 252 replaced with L-serine

Coordinate

252

PsiMod

L-proline removal [MOD:01645]

A protein modification that effectively removes or replaces an L-proline.

L-serine residue [MOD:00025]

A protein modification that effectively converts a source amino acid residue to L-serine.

Disease

Name	Identifier	Synonyms
melanoma	DOID:1909	Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09038 FGF2	1	FGF2(10-155) [extracellular region] (R-HSA-189898)	0.912	9
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.903	11
UniProt:P05230 FGF1	1	FGF1 [extracellular region] (R-HSA-189856)	0.838	5
UniProt:P46934 NEDD4	1	NEDD4 [cytosol] (R-HSA-975992)	0.672	26
UniProt:P51812 RPS6KA3	7	p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm] (R-HSA-444286) p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619989) p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619872) p-T365,S369,T577-RPS6KA3 [cytosol] (R-HSA-9619959) RPS6KA3 [cytosol] (R-HSA-444250) p-4S,T231,T365-RPS6KA3 [nucleoplasm] (R-HSA-199830) RPS6KA3 [nucleoplasm] (R-HSA-199869)	0.671	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.669	3
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.644	6
UniProt:Q8IVI9 NOSTRIN	2	NOSTRIN [endocytic vesicle membrane] (R-HSA-535014) NOSTRIN [plasma membrane] (R-HSA-202134)	0.633	5
UniProt:P23352 ANOS1	1	KAL1 [extracellular region] (R-HSA-5654345)	0.626	7
UniProt:P11362 FGFR1	9	FGFR1 [plasma membrane] (R-HSA-9756433) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) FGFR1 R576W [plasma membrane] (R-HSA-2011844) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241)	0.623	4
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.623	3
UniProt:P21802 FGFR2	20	FGFR2 IIIa TM [extracellular region] (R-HSA-8851703) FGFR2 [plasma membrane] (R-HSA-2023840) FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane] (R-HSA-8853137) FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane] (R-HSA-8853154) FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane] (R-HSA-8853123) FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane] (R-HSA-8853158) FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane] (R-HSA-8853150) FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane] (R-HSA-8853153) FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane] (R-HSA-8853139) FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane] (R-HSA-8853159) FGFR2 N549H [plasma membrane] (R-HSA-2033296) FGFR2 N549K [plasma membrane] (R-HSA-1637910) FGFR2 K660N [plasma membrane] (R-HSA-1637905) p-8Y-FGFR2 K660M [plasma membrane] (R-HSA-2033300) p-8Y-FGFR2 K660E [plasma membrane] (R-HSA-2033298) phosphorylated FGFR2 L764Hfs*4 [plasma membrane] (R-HSA-2071957) p-8Y-FGFR2 W290C [plasma membrane] (R-HSA-2029875) p-8Y-FGFR2 S267P [plasma membrane] (R-HSA-2029879) p-8Y-FGFR2 [plasma membrane] (R-HSA-2029874) p-8Y-FGFR2 N549K [plasma membrane] (R-HSA-2033306)	0.623	3
UniProt:P08908 HTR1A	1	HTR1A [plasma membrane] (R-HSA-390971)	0.62	9
UniProt:P10686 Plcg1	8	p-4Y-Plcg1 [plasma membrane] (R-RNO-9034825) phospho-p-Y771,Y783-PLCG1 [plasma membrane] (R-RNO-1169084) phospho-p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-RNO-202357) p-Plcg1 [plasma membrane] (R-RNO-182042) Plcg1 [plasma membrane] (R-RNO-182093) PLCG1 [plasma membrane] (R-RNO-167682) PLCG1 [cytosol] (R-RNO-202320) phospho-p-4Y-PLCG1 [plasma membrane] (R-RNO-167679)	0.611	4
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.569	4
UniProt:Q9NQH7 XPP3			0.569	3
UniProt:Q8WU20 FRS2	6	p-6Y-FRS2 [plasma membrane] (R-HSA-170959) FRS2 [plasma membrane] (R-HSA-170963) p-8T-FRS2 [plasma membrane] (R-HSA-1270462) p-6Y-FRS2 [cytosol] (R-HSA-190355) FRS2 [cytosol] (R-HSA-190244) p-Y-FRS2 [cytosol] (R-HSA-162551)	0.569	3
UniProt:O35082	2	Kl [plasma membrane] (R-MMU-190198) Kl [extracellular region] (R-MMU-190201)	0.558	2
UniProt:Q9GZV9 FGF23	6	p-FGF23 [endoplasmic reticulum lumen] (R-HSA-8957077) FGF23 [endoplasmic reticulum lumen] (R-HSA-8956697) FGF23(25-251) [Golgi lumen] (R-HSA-8851630) GalNAc-T178-FGF23(25-251) [Golgi lumen] (R-HSA-8851624) FGF23(25-251) [extracellular region] (R-HSA-189891) GalNAc-T178-FGF23(25-251) [extracellular region] (R-HSA-8851633)	0.544	2
UniProt:P22455 FGFR4	12	p-5Y-FGFR4 [plasma membrane] (R-HSA-190330) FGFR4 [plasma membrane] (R-HSA-189921) p5Y-FGFR4 Y367C mutant [plasma membrane] (R-HSA-2011873) p-5Y-FGFR4 N535D [plasma membrane] (R-HSA-2038934) p-5Y-FGFR4 V550L [plasma membrane] (R-HSA-2038935) p-5Y-FGFR4 N535K [plasma membrane] (R-HSA-2038931) p-5Y-FGFR4 V550E [plasma membrane] (R-HSA-2038932) FGFR4 N535D [plasma membrane] (R-HSA-1614427) FGFR4 V550L [plasma membrane] (R-HSA-1614436) FGFR4 V550E [plasma membrane] (R-HSA-1614433) FGFR4 N535K [plasma membrane] (R-HSA-1614430) FGFR4 Y367C [plasma membrane] (R-HSA-1614439)	0.539	3
UniProt:P12830 CDH1	8	CDH1(155-882) [plasma membrane] (R-HSA-198003) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-750) [plasma membrane] (R-HSA-202940) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) CDH1(701-882) [extracellular region] (R-HSA-2534158) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(732-882) [plasma membrane] (R-HSA-3827997)	0.536	3
UniProt:Q7KZF4 SND1	2	SND1(1-593)-BRAF(381-766) fusion [cytosol] (R-HSA-6802469) SND1(1-593)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802552)	0.483	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.483	2
UniProt:P06493 CDK1	11	p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) CDK1 [cytosol] (R-HSA-170075) CDK1 [nucleoplasm] (R-HSA-68889) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-Y4-CDK1 [cytosol] (R-HSA-9836187) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424)	0.483	3
UniProt:O88900	1	Grb14 [cytosol] (R-RNO-204771)	0.471	3

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