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Table of Contents
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2OG [cytosol]
Stable Identifier
R-ALL-29406
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
2-oxoglutarate, 2-oxoglutaric acid, Oxoglutaric acid, 2-Ketoglutaric acid, alpha-Ketoglutaric acid, 2-Oxoglutarate, alpha-ketoglutarate
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to hypoxia (Bos taurus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Bos taurus)
2OG [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Bos taurus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Bos taurus)
2OG [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Bos taurus)
2OG [cytosol]
Metabolism (Bos taurus)
Metabolism of amino acids and derivatives (Bos taurus)
Alanine metabolism (Bos taurus)
PXLP-K314-GPT transaminates L-Ala to form PYR (Bos taurus)
2OG [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Bos taurus)
2OG [cytosol]
Aspartate and asparagine metabolism (Bos taurus)
PXLP-K259-GOT1 dimer deaminates L-Asp (Bos taurus)
2OG [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Bos taurus)
2OG [cytosol]
Branched-chain amino acid catabolism (Bos taurus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Bos taurus)
2OG [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Bos taurus)
2OG [cytosol]
Carnitine synthesis (Bos taurus)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Bos taurus)
2OG [cytosol]
Lysine catabolism (Bos taurus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Bos taurus)
2OG [cytosol]
Phenylalanine and tyrosine metabolism (Bos taurus)
Tyrosine catabolism (Bos taurus)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Bos taurus)
2OG [cytosol]
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Bos taurus)
2OG [cytosol]
Serine biosynthesis (Bos taurus)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Bos taurus)
2OG [cytosol]
Metabolism of carbohydrates (Bos taurus)
Glucose metabolism (Bos taurus)
Gluconeogenesis (Bos taurus)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Bos taurus)
2OG [cytosol]
PXLP-K259-GOT1 dimer deaminates L-Asp (Bos taurus)
2OG [cytosol]
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Bos taurus)
2OG [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of cofactors (Bos taurus)
NADPH regeneration (Bos taurus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Bos taurus)
2OG [cytosol]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Organic cation/anion/zwitterion transport (Bos taurus)
Organic anion transport (Bos taurus)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Bos taurus)
2OG [cytosol]
OAT2 and OAT4 mediate transport of sulphate conjugates (Bos taurus)
2OG [cytosol]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to hypoxia (Caenorhabditis elegans)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Caenorhabditis elegans)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)
2OG [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)
2OG [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Alanine metabolism (Caenorhabditis elegans)
PXLP-K314-GPT transaminates L-Ala to form PYR (Caenorhabditis elegans)
2OG [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Caenorhabditis elegans)
2OG [cytosol]
Aspartate and asparagine metabolism (Caenorhabditis elegans)
PXLP-K259-GOT1 dimer deaminates L-Asp (Caenorhabditis elegans)
2OG [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Caenorhabditis elegans)
2OG [cytosol]
Branched-chain amino acid catabolism (Caenorhabditis elegans)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Caenorhabditis elegans)
2OG [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Caenorhabditis elegans)
2OG [cytosol]
Carnitine synthesis (Caenorhabditis elegans)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Caenorhabditis elegans)
2OG [cytosol]
Lysine catabolism (Caenorhabditis elegans)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Caenorhabditis elegans)
2OG [cytosol]
Phenylalanine and tyrosine metabolism (Caenorhabditis elegans)
Tyrosine catabolism (Caenorhabditis elegans)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Caenorhabditis elegans)
2OG [cytosol]
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Caenorhabditis elegans)
2OG [cytosol]
Serine biosynthesis (Caenorhabditis elegans)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Caenorhabditis elegans)
2OG [cytosol]
Metabolism of carbohydrates (Caenorhabditis elegans)
Glucose metabolism (Caenorhabditis elegans)
Gluconeogenesis (Caenorhabditis elegans)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Caenorhabditis elegans)
2OG [cytosol]
PXLP-K259-GOT1 dimer deaminates L-Asp (Caenorhabditis elegans)
2OG [cytosol]
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Caenorhabditis elegans)
2OG [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of cofactors (Caenorhabditis elegans)
NADPH regeneration (Caenorhabditis elegans)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Caenorhabditis elegans)
2OG [cytosol]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Organic cation/anion/zwitterion transport (Caenorhabditis elegans)
Organic anion transport (Caenorhabditis elegans)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Caenorhabditis elegans)
2OG [cytosol]
OAT2 and OAT4 mediate transport of sulphate conjugates (Caenorhabditis elegans)
2OG [cytosol]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to hypoxia (Canis familiaris)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Canis familiaris)
2OG [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Canis familiaris)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Canis familiaris)
2OG [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Canis familiaris)
2OG [cytosol]
Metabolism (Canis familiaris)
Metabolism of amino acids and derivatives (Canis familiaris)
Aspartate and asparagine metabolism (Canis familiaris)
PXLP-K259-GOT1 dimer deaminates L-Asp (Canis familiaris)
2OG [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Canis familiaris)
2OG [cytosol]
Branched-chain amino acid catabolism (Canis familiaris)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Canis familiaris)
2OG [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Canis familiaris)
2OG [cytosol]
Carnitine synthesis (Canis familiaris)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Canis familiaris)
2OG [cytosol]
Lysine catabolism (Canis familiaris)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Canis familiaris)
2OG [cytosol]
Phenylalanine and tyrosine metabolism (Canis familiaris)
Tyrosine catabolism (Canis familiaris)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Canis familiaris)
2OG [cytosol]
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Canis familiaris)
2OG [cytosol]
Serine biosynthesis (Canis familiaris)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Canis familiaris)
2OG [cytosol]
Metabolism of carbohydrates (Canis familiaris)
Glucose metabolism (Canis familiaris)
Gluconeogenesis (Canis familiaris)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Canis familiaris)
2OG [cytosol]
PXLP-K259-GOT1 dimer deaminates L-Asp (Canis familiaris)
2OG [cytosol]
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Canis familiaris)
2OG [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of cofactors (Canis familiaris)
NADPH regeneration (Canis familiaris)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Canis familiaris)
2OG [cytosol]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Organic cation/anion/zwitterion transport (Canis familiaris)
Organic anion transport (Canis familiaris)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Canis familiaris)
2OG [cytosol]
OAT2 and OAT4 mediate transport of sulphate conjugates (Canis familiaris)
2OG [cytosol]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to hypoxia (Danio rerio)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Danio rerio)
2OG [cytosol]
Metabolism (Danio rerio)
Metabolism of amino acids and derivatives (Danio rerio)
Alanine metabolism (Danio rerio)
PXLP-K314-GPT transaminates L-Ala to form PYR (Danio rerio)
2OG [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Danio rerio)
2OG [cytosol]
Aspartate and asparagine metabolism (Danio rerio)
PXLP-K259-GOT1 dimer deaminates L-Asp (Danio rerio)
2OG [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Danio rerio)
2OG [cytosol]
Branched-chain amino acid catabolism (Danio rerio)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Danio rerio)
2OG [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Danio rerio)
2OG [cytosol]
Carnitine synthesis (Danio rerio)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Danio rerio)
2OG [cytosol]
Lysine catabolism (Danio rerio)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Danio rerio)
2OG [cytosol]
Phenylalanine and tyrosine metabolism (Danio rerio)
Tyrosine catabolism (Danio rerio)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Danio rerio)
2OG [cytosol]
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Danio rerio)
2OG [cytosol]
Serine biosynthesis (Danio rerio)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Danio rerio)
2OG [cytosol]
Metabolism of carbohydrates (Danio rerio)
Glucose metabolism (Danio rerio)
Gluconeogenesis (Danio rerio)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Danio rerio)
2OG [cytosol]
PXLP-K259-GOT1 dimer deaminates L-Asp (Danio rerio)
2OG [cytosol]
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Danio rerio)
2OG [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of cofactors (Danio rerio)
NADPH regeneration (Danio rerio)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Danio rerio)
2OG [cytosol]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
Organic cation/anion/zwitterion transport (Danio rerio)
Organic anion transport (Danio rerio)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Danio rerio)
2OG [cytosol]
OAT2 and OAT4 mediate transport of sulphate conjugates (Danio rerio)
2OG [cytosol]
Metabolism (Dictyostelium discoideum)
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Alanine metabolism (Dictyostelium discoideum)
PXLP-K314-GPT transaminates L-Ala to form PYR (Dictyostelium discoideum)
2OG [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Dictyostelium discoideum)
2OG [cytosol]
Branched-chain amino acid catabolism (Dictyostelium discoideum)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Dictyostelium discoideum)
2OG [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Dictyostelium discoideum)
2OG [cytosol]
Lysine catabolism (Dictyostelium discoideum)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Dictyostelium discoideum)
2OG [cytosol]
Phenylalanine and tyrosine metabolism (Dictyostelium discoideum)
Tyrosine catabolism (Dictyostelium discoideum)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Dictyostelium discoideum)
2OG [cytosol]
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Dictyostelium discoideum)
2OG [cytosol]
Serine biosynthesis (Dictyostelium discoideum)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Dictyostelium discoideum)
2OG [cytosol]
Metabolism of carbohydrates (Dictyostelium discoideum)
Glucose metabolism (Dictyostelium discoideum)
Gluconeogenesis (Dictyostelium discoideum)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Dictyostelium discoideum)
2OG [cytosol]
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Dictyostelium discoideum)
2OG [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of cofactors (Dictyostelium discoideum)
NADPH regeneration (Dictyostelium discoideum)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Dictyostelium discoideum)
2OG [cytosol]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to hypoxia (Drosophila melanogaster)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Drosophila melanogaster)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)
2OG [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)
2OG [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Alanine metabolism (Drosophila melanogaster)
PXLP-K314-GPT transaminates L-Ala to form PYR (Drosophila melanogaster)
2OG [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Drosophila melanogaster)
2OG [cytosol]
Aspartate and asparagine metabolism (Drosophila melanogaster)
PXLP-K259-GOT1 dimer deaminates L-Asp (Drosophila melanogaster)
2OG [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Drosophila melanogaster)
2OG [cytosol]
Branched-chain amino acid catabolism (Drosophila melanogaster)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Drosophila melanogaster)
2OG [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Drosophila melanogaster)
2OG [cytosol]
Carnitine synthesis (Drosophila melanogaster)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Drosophila melanogaster)
2OG [cytosol]
Lysine catabolism (Drosophila melanogaster)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Drosophila melanogaster)
2OG [cytosol]
Phenylalanine and tyrosine metabolism (Drosophila melanogaster)
Tyrosine catabolism (Drosophila melanogaster)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Drosophila melanogaster)
2OG [cytosol]
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Drosophila melanogaster)
2OG [cytosol]
Serine biosynthesis (Drosophila melanogaster)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Drosophila melanogaster)
2OG [cytosol]
Metabolism of carbohydrates (Drosophila melanogaster)
Glucose metabolism (Drosophila melanogaster)
Gluconeogenesis (Drosophila melanogaster)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Drosophila melanogaster)
2OG [cytosol]
PXLP-K259-GOT1 dimer deaminates L-Asp (Drosophila melanogaster)
2OG [cytosol]
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Drosophila melanogaster)
2OG [cytosol]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of cofactors (Drosophila melanogaster)
NADPH regeneration (Drosophila melanogaster)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Drosophila melanogaster)
2OG [cytosol]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Organic cation/anion/zwitterion transport (Drosophila melanogaster)
Organic anion transport (Drosophila melanogaster)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Drosophila melanogaster)
2OG [cytosol]
OAT2 and OAT4 mediate transport of sulphate conjugates (Drosophila melanogaster)
2OG [cytosol]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to hypoxia (Gallus gallus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Gallus gallus)
2OG [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Gallus gallus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Gallus gallus)
2OG [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Gallus gallus)
2OG [cytosol]
Metabolism (Gallus gallus)
Amino acid metabolism (Gallus gallus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Gallus gallus)
2OG [cytosol]
aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)
2OG [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) (Gallus gallus)
2OG [cytosol]
Carbohydrate metabolism (Gallus gallus)
Gluconeogenesis (Gallus gallus)
2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix] (Gallus gallus)
2OG [cytosol]
aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)
2OG [cytosol]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
Organic cation/anion/zwitterion transport (Gallus gallus)
Organic anion transport (Gallus gallus)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Gallus gallus)
2OG [cytosol]
OAT2 and OAT4 mediate transport of sulphate conjugates (Gallus gallus)
2OG [cytosol]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Homo sapiens)
2OG [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
2OG [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Homo sapiens)
2OG [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)
2OG [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (Homo sapiens)
2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1] (Homo sapiens)
2OG [cytosol]
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Alanine metabolism (Homo sapiens)
PXLP-K314-GPT transaminates L-Ala to form PYR (Homo sapiens)
2OG [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Homo sapiens)
2OG [cytosol]
Aspartate and asparagine metabolism (Homo sapiens)
PXLP-K259-GOT1 dimer deaminates L-Asp (Homo sapiens)
2OG [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Homo sapiens)
2OG [cytosol]
Branched-chain amino acid catabolism (Homo sapiens)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Homo sapiens)
2OG [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Homo sapiens)
2OG [cytosol]
Carnitine synthesis (Homo sapiens)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Homo sapiens)
2OG [cytosol]
Lysine catabolism (Homo sapiens)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Homo sapiens)
2OG [cytosol]
Phenylalanine and tyrosine metabolism (Homo sapiens)
Tyrosine catabolism (Homo sapiens)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Homo sapiens)
2OG [cytosol]
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Homo sapiens)
2OG [cytosol]
Serine biosynthesis (Homo sapiens)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Homo sapiens)
2OG [cytosol]
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Gluconeogenesis (Homo sapiens)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Homo sapiens)
2OG [cytosol]
PXLP-K259-GOT1 dimer deaminates L-Asp (Homo sapiens)
2OG [cytosol]
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Homo sapiens)
2OG [cytosol]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of cofactors (Homo sapiens)
NADPH regeneration (Homo sapiens)
Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane (Homo sapiens)
2OG [cytosol]
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Homo sapiens)
2OG [cytosol]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Organic cation/anion/zwitterion transport (Homo sapiens)
Organic anion transport (Homo sapiens)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Homo sapiens)
2OG [cytosol]
OAT2 and OAT4 mediate transport of sulphate conjugates (Homo sapiens)
2OG [cytosol]
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to hypoxia (Mus musculus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Mus musculus)
2OG [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Mus musculus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Mus musculus)
2OG [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Mus musculus)
2OG [cytosol]
Metabolism (Mus musculus)
Metabolism of amino acids and derivatives (Mus musculus)
Alanine metabolism (Mus musculus)
PXLP-K314-GPT transaminates L-Ala to form PYR (Mus musculus)
2OG [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Mus musculus)
2OG [cytosol]
Aspartate and asparagine metabolism (Mus musculus)
PXLP-K259-GOT1 dimer deaminates L-Asp (Mus musculus)
2OG [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Mus musculus)
2OG [cytosol]
Branched-chain amino acid catabolism (Mus musculus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Mus musculus)
2OG [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Mus musculus)
2OG [cytosol]
Carnitine synthesis (Mus musculus)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Mus musculus)
2OG [cytosol]
Lysine catabolism (Mus musculus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Mus musculus)
2OG [cytosol]
Phenylalanine and tyrosine metabolism (Mus musculus)
Tyrosine catabolism (Mus musculus)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Mus musculus)
2OG [cytosol]
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Mus musculus)
2OG [cytosol]
Serine biosynthesis (Mus musculus)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Mus musculus)
2OG [cytosol]
Metabolism of carbohydrates (Mus musculus)
Glucose metabolism (Mus musculus)
Gluconeogenesis (Mus musculus)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Mus musculus)
2OG [cytosol]
PXLP-K259-GOT1 dimer deaminates L-Asp (Mus musculus)
2OG [cytosol]
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Mus musculus)
2OG [cytosol]
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of cofactors (Mus musculus)
NADPH regeneration (Mus musculus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Mus musculus)
2OG [cytosol]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of bile salts and organic acids, metal ions and amine compounds (Mus musculus)
Organic cation/anion/zwitterion transport (Mus musculus)
Organic anion transport (Mus musculus)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Mus musculus)
2OG [cytosol]
OAT2 and OAT4 mediate transport of sulphate conjugates (Mus musculus)
2OG [cytosol]
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to hypoxia (Rattus norvegicus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Rattus norvegicus)
2OG [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Rattus norvegicus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)
2OG [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Rattus norvegicus)
2OG [cytosol]
Metabolism (Rattus norvegicus)
Metabolism of amino acids and derivatives (Rattus norvegicus)
Alanine metabolism (Rattus norvegicus)
PXLP-K314-GPT transaminates L-Ala to form PYR (Rattus norvegicus)
2OG [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Rattus norvegicus)
2OG [cytosol]
Aspartate and asparagine metabolism (Rattus norvegicus)
PXLP-K259-GOT1 dimer deaminates L-Asp (Rattus norvegicus)
2OG [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Rattus norvegicus)
2OG [cytosol]
Branched-chain amino acid catabolism (Rattus norvegicus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Rattus norvegicus)
2OG [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Rattus norvegicus)
2OG [cytosol]
Carnitine synthesis (Rattus norvegicus)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Rattus norvegicus)
2OG [cytosol]
Lysine catabolism (Rattus norvegicus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Rattus norvegicus)
2OG [cytosol]
Phenylalanine and tyrosine metabolism (Rattus norvegicus)
Tyrosine catabolism (Rattus norvegicus)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Rattus norvegicus)
2OG [cytosol]
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Rattus norvegicus)
2OG [cytosol]
Serine biosynthesis (Rattus norvegicus)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Rattus norvegicus)
2OG [cytosol]
Metabolism of carbohydrates (Rattus norvegicus)
Glucose metabolism (Rattus norvegicus)
Gluconeogenesis (Rattus norvegicus)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Rattus norvegicus)
2OG [cytosol]
PXLP-K259-GOT1 dimer deaminates L-Asp (Rattus norvegicus)
2OG [cytosol]
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Rattus norvegicus)
2OG [cytosol]
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of cofactors (Rattus norvegicus)
NADPH regeneration (Rattus norvegicus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Rattus norvegicus)
2OG [cytosol]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of bile salts and organic acids, metal ions and amine compounds (Rattus norvegicus)
Organic cation/anion/zwitterion transport (Rattus norvegicus)
Organic anion transport (Rattus norvegicus)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Rattus norvegicus)
2OG [cytosol]
OAT2 and OAT4 mediate transport of sulphate conjugates (Rattus norvegicus)
2OG [cytosol]
Metabolism (Saccharomyces cerevisiae)
Metabolism of amino acids and derivatives (Saccharomyces cerevisiae)
Alanine metabolism (Saccharomyces cerevisiae)
PXLP-K314-GPT transaminates L-Ala to form PYR (Saccharomyces cerevisiae)
2OG [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Saccharomyces cerevisiae)
2OG [cytosol]
Aspartate and asparagine metabolism (Saccharomyces cerevisiae)
PXLP-K259-GOT1 dimer deaminates L-Asp (Saccharomyces cerevisiae)
2OG [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Saccharomyces cerevisiae)
2OG [cytosol]
Branched-chain amino acid catabolism (Saccharomyces cerevisiae)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Saccharomyces cerevisiae)
2OG [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Saccharomyces cerevisiae)
2OG [cytosol]
Carnitine synthesis (Saccharomyces cerevisiae)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Saccharomyces cerevisiae)
2OG [cytosol]
Serine biosynthesis (Saccharomyces cerevisiae)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Saccharomyces cerevisiae)
2OG [cytosol]
Metabolism of carbohydrates (Saccharomyces cerevisiae)
Glucose metabolism (Saccharomyces cerevisiae)
Gluconeogenesis (Saccharomyces cerevisiae)
PXLP-K259-GOT1 dimer deaminates L-Asp (Saccharomyces cerevisiae)
2OG [cytosol]
Metabolism of vitamins and cofactors (Saccharomyces cerevisiae)
Metabolism of cofactors (Saccharomyces cerevisiae)
NADPH regeneration (Saccharomyces cerevisiae)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)
2OG [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of amino acids and derivatives (Schizosaccharomyces pombe)
Alanine metabolism (Schizosaccharomyces pombe)
PXLP-K314-GPT transaminates L-Ala to form PYR (Schizosaccharomyces pombe)
2OG [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Schizosaccharomyces pombe)
2OG [cytosol]
Aspartate and asparagine metabolism (Schizosaccharomyces pombe)
PXLP-K259-GOT1 dimer deaminates L-Asp (Schizosaccharomyces pombe)
2OG [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Schizosaccharomyces pombe)
2OG [cytosol]
Branched-chain amino acid catabolism (Schizosaccharomyces pombe)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Schizosaccharomyces pombe)
2OG [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Schizosaccharomyces pombe)
2OG [cytosol]
Serine biosynthesis (Schizosaccharomyces pombe)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Schizosaccharomyces pombe)
2OG [cytosol]
Metabolism of carbohydrates (Schizosaccharomyces pombe)
Glucose metabolism (Schizosaccharomyces pombe)
Gluconeogenesis (Schizosaccharomyces pombe)
PXLP-K259-GOT1 dimer deaminates L-Asp (Schizosaccharomyces pombe)
2OG [cytosol]
Metabolism of vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of cofactors (Schizosaccharomyces pombe)
NADPH regeneration (Schizosaccharomyces pombe)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)
2OG [cytosol]
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to hypoxia (Sus scrofa)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Sus scrofa)
2OG [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Sus scrofa)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Sus scrofa)
2OG [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Sus scrofa)
2OG [cytosol]
Metabolism (Sus scrofa)
Metabolism of amino acids and derivatives (Sus scrofa)
Alanine metabolism (Sus scrofa)
PXLP-K314-GPT transaminates L-Ala to form PYR (Sus scrofa)
2OG [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Sus scrofa)
2OG [cytosol]
Aspartate and asparagine metabolism (Sus scrofa)
PXLP-K259-GOT1 dimer deaminates L-Asp (Sus scrofa)
2OG [cytosol]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Sus scrofa)
2OG [cytosol]
Branched-chain amino acid catabolism (Sus scrofa)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Sus scrofa)
2OG [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Sus scrofa)
2OG [cytosol]
Carnitine synthesis (Sus scrofa)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Sus scrofa)
2OG [cytosol]
Lysine catabolism (Sus scrofa)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Sus scrofa)
2OG [cytosol]
Phenylalanine and tyrosine metabolism (Sus scrofa)
Tyrosine catabolism (Sus scrofa)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Sus scrofa)
2OG [cytosol]
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Sus scrofa)
2OG [cytosol]
Serine biosynthesis (Sus scrofa)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Sus scrofa)
2OG [cytosol]
Metabolism of carbohydrates (Sus scrofa)
Glucose metabolism (Sus scrofa)
Gluconeogenesis (Sus scrofa)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Sus scrofa)
2OG [cytosol]
PXLP-K259-GOT1 dimer deaminates L-Asp (Sus scrofa)
2OG [cytosol]
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Sus scrofa)
2OG [cytosol]
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of cofactors (Sus scrofa)
NADPH regeneration (Sus scrofa)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Sus scrofa)
2OG [cytosol]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of bile salts and organic acids, metal ions and amine compounds (Sus scrofa)
Organic cation/anion/zwitterion transport (Sus scrofa)
Organic anion transport (Sus scrofa)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Sus scrofa)
2OG [cytosol]
OAT2 and OAT4 mediate transport of sulphate conjugates (Sus scrofa)
2OG [cytosol]
Cellular responses to stimuli (Xenopus tropicalis)
Cellular responses to stress (Xenopus tropicalis)
Cellular response to hypoxia (Xenopus tropicalis)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Xenopus tropicalis)
2OG [cytosol]
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Xenopus tropicalis)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Xenopus tropicalis)
2OG [cytosol]
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Xenopus tropicalis)
2OG [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Alanine metabolism (Xenopus tropicalis)
PXLP-K314-GPT transaminates L-Ala to form PYR (Xenopus tropicalis)
2OG [cytosol]
PXLP-K314-GPT transaminates PYR to form L-Ala (Xenopus tropicalis)
2OG [cytosol]
Branched-chain amino acid catabolism (Xenopus tropicalis)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Xenopus tropicalis)
2OG [cytosol]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Xenopus tropicalis)
2OG [cytosol]
Lysine catabolism (Xenopus tropicalis)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Xenopus tropicalis)
2OG [cytosol]
Phenylalanine and tyrosine metabolism (Xenopus tropicalis)
Tyrosine catabolism (Xenopus tropicalis)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Xenopus tropicalis)
2OG [cytosol]
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Xenopus tropicalis)
2OG [cytosol]
Serine biosynthesis (Xenopus tropicalis)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Xenopus tropicalis)
2OG [cytosol]
Metabolism of carbohydrates (Xenopus tropicalis)
Glucose metabolism (Xenopus tropicalis)
Gluconeogenesis (Xenopus tropicalis)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Xenopus tropicalis)
2OG [cytosol]
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Xenopus tropicalis)
2OG [cytosol]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of bile salts and organic acids, metal ions and amine compounds (Xenopus tropicalis)
Organic cation/anion/zwitterion transport (Xenopus tropicalis)
Organic anion transport (Xenopus tropicalis)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Xenopus tropicalis)
2OG [cytosol]
OAT2 and OAT4 mediate transport of sulphate conjugates (Xenopus tropicalis)
2OG [cytosol]
External Reference Information
External Reference
2-oxoglutarate(2-) [ChEBI:16810]
Participates
as an input of
aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)
OAT2 and OAT4 mediate transport of sulphate conjugates (Caenorhabditis elegans)
OAT2 and OAT4 mediate transport of sulphate conjugates (Drosophila melanogaster)
OAT2 and OAT4 mediate transport of sulphate conjugates (Gallus gallus)
OAT2 and OAT4 mediate transport of sulphate conjugates (Xenopus tropicalis)
OAT2 and OAT4 mediate transport of sulphate conjugates (Danio rerio)
OAT2 and OAT4 mediate transport of sulphate conjugates (Sus scrofa)
OAT2 and OAT4 mediate transport of sulphate conjugates (Bos taurus)
OAT2 and OAT4 mediate transport of sulphate conjugates (Canis familiaris)
OAT2 and OAT4 mediate transport of sulphate conjugates (Rattus norvegicus)
OAT2 and OAT4 mediate transport of sulphate conjugates (Mus musculus)
OAT2 and OAT4 mediate transport of sulphate conjugates (Homo sapiens)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Caenorhabditis elegans)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Drosophila melanogaster)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Gallus gallus)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Xenopus tropicalis)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Danio rerio)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Sus scrofa)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Bos taurus)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Canis familiaris)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Rattus norvegicus)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Mus musculus)
OAT1-3 transport organic anions with antiport of dicarboxylic acids (Homo sapiens)
2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1] (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Gallus gallus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Xenopus tropicalis)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Bos taurus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Canis familiaris)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Rattus norvegicus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Mus musculus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Sus scrofa)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Gallus gallus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Xenopus tropicalis)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Bos taurus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Canis familiaris)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Mus musculus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Sus scrofa)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Gallus gallus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Xenopus tropicalis)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Danio rerio)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Bos taurus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Canis familiaris)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Rattus norvegicus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Mus musculus)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Homo sapiens)
Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A) (Sus scrofa)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Saccharomyces cerevisiae)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Caenorhabditis elegans)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Drosophila melanogaster)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Gallus gallus)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Danio rerio)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Sus scrofa)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Bos taurus)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Canis familiaris)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Rattus norvegicus)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Mus musculus)
BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA (Homo sapiens)
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Dictyostelium discoideum)
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Caenorhabditis elegans)
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Drosophila melanogaster)
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Gallus gallus)
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Xenopus tropicalis)
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Danio rerio)
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Sus scrofa)
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Bos taurus)
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Canis familiaris)
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Rattus norvegicus)
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Mus musculus)
tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate (Homo sapiens)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Saccharomyces cerevisiae)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Schizosaccharomyces pombe)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Dictyostelium discoideum)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Caenorhabditis elegans)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Drosophila melanogaster)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Gallus gallus)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Xenopus tropicalis)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Danio rerio)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Sus scrofa)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Bos taurus)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Canis familiaris)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Rattus norvegicus)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Mus musculus)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] (Homo sapiens)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Dictyostelium discoideum)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Caenorhabditis elegans)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Drosophila melanogaster)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Gallus gallus)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Xenopus tropicalis)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Danio rerio)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Sus scrofa)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Bos taurus)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Canis familiaris)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Rattus norvegicus)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Mus musculus)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Homo sapiens)
PXLP-K259-GOT1 dimer deaminates L-Asp (Saccharomyces cerevisiae)
PXLP-K259-GOT1 dimer deaminates L-Asp (Schizosaccharomyces pombe)
PXLP-K259-GOT1 dimer deaminates L-Asp (Caenorhabditis elegans)
PXLP-K259-GOT1 dimer deaminates L-Asp (Drosophila melanogaster)
PXLP-K259-GOT1 dimer deaminates L-Asp (Gallus gallus)
PXLP-K259-GOT1 dimer deaminates L-Asp (Danio rerio)
PXLP-K259-GOT1 dimer deaminates L-Asp (Sus scrofa)
PXLP-K259-GOT1 dimer deaminates L-Asp (Bos taurus)
PXLP-K259-GOT1 dimer deaminates L-Asp (Canis familiaris)
PXLP-K259-GOT1 dimer deaminates L-Asp (Rattus norvegicus)
PXLP-K259-GOT1 dimer deaminates L-Asp (Mus musculus)
PXLP-K259-GOT1 dimer deaminates L-Asp (Homo sapiens)
PXLP-K314-GPT transaminates L-Ala to form PYR (Homo sapiens)
PXLP-K314-GPT transaminates L-Ala to form PYR (Mus musculus)
PXLP-K314-GPT transaminates L-Ala to form PYR (Rattus norvegicus)
PXLP-K314-GPT transaminates L-Ala to form PYR (Bos taurus)
PXLP-K314-GPT transaminates L-Ala to form PYR (Sus scrofa)
PXLP-K314-GPT transaminates L-Ala to form PYR (Danio rerio)
PXLP-K314-GPT transaminates L-Ala to form PYR (Xenopus tropicalis)
PXLP-K314-GPT transaminates L-Ala to form PYR (Drosophila melanogaster)
PXLP-K314-GPT transaminates L-Ala to form PYR (Caenorhabditis elegans)
PXLP-K314-GPT transaminates L-Ala to form PYR (Dictyostelium discoideum)
PXLP-K314-GPT transaminates L-Ala to form PYR (Schizosaccharomyces pombe)
PXLP-K314-GPT transaminates L-Ala to form PYR (Saccharomyces cerevisiae)
as an output of
2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix] (Gallus gallus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Gallus gallus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) (Gallus gallus)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Saccharomyces cerevisiae)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Schizosaccharomyces pombe)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Dictyostelium discoideum)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Caenorhabditis elegans)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Drosophila melanogaster)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Gallus gallus)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Xenopus tropicalis)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Danio rerio)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Sus scrofa)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Bos taurus)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Canis familiaris)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Rattus norvegicus)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Mus musculus)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Homo sapiens)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Dictyostelium discoideum)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Caenorhabditis elegans)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Drosophila melanogaster)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Gallus gallus)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Xenopus tropicalis)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Danio rerio)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Sus scrofa)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Bos taurus)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Canis familiaris)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Rattus norvegicus)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Mus musculus)
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate (Homo sapiens)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Saccharomyces cerevisiae)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Schizosaccharomyces pombe)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Dictyostelium discoideum)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Caenorhabditis elegans)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Drosophila melanogaster)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Gallus gallus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Xenopus tropicalis)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Danio rerio)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Sus scrofa)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Bos taurus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Canis familiaris)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Rattus norvegicus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Mus musculus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] (Homo sapiens)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Saccharomyces cerevisiae)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Schizosaccharomyces pombe)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Dictyostelium discoideum)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Caenorhabditis elegans)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Drosophila melanogaster)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Gallus gallus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Danio rerio)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Bos taurus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Canis familiaris)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Rattus norvegicus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Mus musculus)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Homo sapiens)
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ (Sus scrofa)
Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane (Homo sapiens)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Dictyostelium discoideum)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Caenorhabditis elegans)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Drosophila melanogaster)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Gallus gallus)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Xenopus tropicalis)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Danio rerio)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Sus scrofa)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Bos taurus)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Canis familiaris)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Rattus norvegicus)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Mus musculus)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Homo sapiens)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Dictyostelium discoideum)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Caenorhabditis elegans)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Drosophila melanogaster)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Homo sapiens)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Mus musculus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Rattus norvegicus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Canis familiaris)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Bos taurus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Sus scrofa)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Danio rerio)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Gallus gallus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Drosophila melanogaster)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Caenorhabditis elegans)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Schizosaccharomyces pombe)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Saccharomyces cerevisiae)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Homo sapiens)
PXLP-K314-GPT transaminates PYR to form L-Ala (Homo sapiens)
PXLP-K314-GPT transaminates PYR to form L-Ala (Mus musculus)
PXLP-K314-GPT transaminates PYR to form L-Ala (Rattus norvegicus)
PXLP-K314-GPT transaminates PYR to form L-Ala (Bos taurus)
PXLP-K314-GPT transaminates PYR to form L-Ala (Sus scrofa)
PXLP-K314-GPT transaminates PYR to form L-Ala (Danio rerio)
PXLP-K314-GPT transaminates PYR to form L-Ala (Xenopus tropicalis)
PXLP-K314-GPT transaminates PYR to form L-Ala (Drosophila melanogaster)
PXLP-K314-GPT transaminates PYR to form L-Ala (Caenorhabditis elegans)
PXLP-K314-GPT transaminates PYR to form L-Ala (Dictyostelium discoideum)
PXLP-K314-GPT transaminates PYR to form L-Ala (Schizosaccharomyces pombe)
PXLP-K314-GPT transaminates PYR to form L-Ala (Saccharomyces cerevisiae)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Mus musculus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Rattus norvegicus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Canis familiaris)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Bos taurus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Sus scrofa)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Danio rerio)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Xenopus tropicalis)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Gallus gallus)
Other forms of this molecule
2OG [cytoplasm]
2OG [endoplasmic reticulum lumen]
2OG [peroxisomal matrix]
2OG [nucleoplasm]
2OG [extracellular region]
2OG [mitochondrial matrix]
Cross References
KNApSAcK
C00000769
AraCyc
2-KETOGLUTARATE
CAS
328-50-7
COMPOUND
C00026
PubChem Compound
164533
ZINC
000001532519
KEGG Gene
C00026
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![2OG [cytosol] icon](/icon/R-ICO-012365.svg){kind=icon}
