PXLP-K259-GOT1 transaminates 2-OG and L-Asp

Stable Identifier
R-HSA-70592
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate, 2-oxoglutarate + L-aspartate => L-glutamate + oxaloacetate
ReviewStatus
5/5
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PXLP-K259-GOT1 transaminates 2-OG and L-Asp
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Cytosolic GOT1 (glutamate oxaloacetate transaminase 1, also known as aspartate aminotransferase 1) catalyzes the reversible reaction of aspartate (L-Asp) and 2-oxoglutarate (2OG, alpha-ketoglutarate) to form oxaloacetate (OA) and glutamate (L-Glu) (Doyle et al. 1990). Crystallographic data show the enzyme is a homodimer (Holt et al., 2018).
Literature References
PubMed ID Title Journal Year
2241899 The amino acid sequence of cytosolic aspartate aminotransferase from human liver

Bossa, F, Doonan, S, Doyle, JM, Schinina, ME

Biochem J 1990
30365304 Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors

Lairson, LL, Anglin, J, Mullarky, E, Beheshti Zavareh, R, Kremer, DM, Haldar, D, Assar, Z, Cantley, LC, Lyssiotis, CA, Kimmelman, AC, Lin, L, Mashadova, O, Stein, AJ, Holt, MC

Biochemistry 2018
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Output
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as an event of
Catalyst Activity

L-aspartate:2-oxoglutarate aminotransferase activity of PXLP-K259-GOT1 dimer [cytosol]

Physical Entity
PXLP-K259-GOT1 dimer [cytosol] (Homo sapiens)
Activity
L-aspartate:2-oxoglutarate aminotransferase activity (GO:0004069)
Orthologous Events
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Bos taurus)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Caenorhabditis elegans)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Canis familiaris)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Danio rerio)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Drosophila melanogaster)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Gallus gallus)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Mus musculus)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Plasmodium falciparum)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Rattus norvegicus)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Saccharomyces cerevisiae)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Schizosaccharomyces pombe)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Sus scrofa)
PXLP-K259-GOT1 transaminates 2-OG and L-Asp (Xenopus tropicalis)
Cross References
RHEA
Rhea
Reviewed
Hill, DP  (2022-08-29)
Harris, RA  (2008-09-10)
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