PXLP-K259-GOT1 dimer deaminates L-Asp

Stable Identifier
R-HSA-70592
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1]
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PXLP-K259-GOT1 dimer deaminates L-Asp
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Cytosolic aspartate aminotransferase (glutamate oxaloacetate transaminase 1 - GOT1) catalyzes the reversible reaction of aspartate and 2-oxoglutarate (alpha-ketoglutarate) to form oxaloacetate and glutamate (Doyle et al. 1990). Unpublished crystallographic data (PBD 3IIO) suggest the enzyme is a homodimer).

Literature References
PubMed ID Title Journal Year
2241899 The amino acid sequence of cytosolic aspartate aminotransferase from human liver

Doyle, JM, Schinina, ME, Bossa, F, Doonan, S

Biochem J 1990
Participants
Input
Output
Participant Of
hasEvent
Event Information
Reverse Reaction
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Homo sapiens)
Catalyst Activity
Catalyst Activity
Title
L-aspartate:2-oxoglutarate aminotransferase activity of PXLP-K259-GOT1 dimer [cytosol]
Physical Entity
PXLP-K259-GOT1 dimer [cytosol]
Activity
L-aspartate:2-oxoglutarate aminotransferase activity (0004069)
Orthologous Events
PXLP-K259-GOT1 dimer deaminates L-Asp (Bos taurus)
PXLP-K259-GOT1 dimer deaminates L-Asp (Caenorhabditis elegans)
PXLP-K259-GOT1 dimer deaminates L-Asp (Canis familiaris)
PXLP-K259-GOT1 dimer deaminates L-Asp (Danio rerio)
PXLP-K259-GOT1 dimer deaminates L-Asp (Dictyostelium discoideum)
PXLP-K259-GOT1 dimer deaminates L-Asp (Drosophila melanogaster)
PXLP-K259-GOT1 dimer deaminates L-Asp (Gallus gallus)
PXLP-K259-GOT1 dimer deaminates L-Asp (Mus musculus)
PXLP-K259-GOT1 dimer deaminates L-Asp (Plasmodium falciparum)
PXLP-K259-GOT1 dimer deaminates L-Asp (Rattus norvegicus)
PXLP-K259-GOT1 dimer deaminates L-Asp (Saccharomyces cerevisiae)
PXLP-K259-GOT1 dimer deaminates L-Asp (Schizosaccharomyces pombe)
PXLP-K259-GOT1 dimer deaminates L-Asp (Sus scrofa)
PXLP-K259-GOT1 dimer deaminates L-Asp (Xenopus tropicalis)
Cross References
Rhea
Reviewed
Harris, RA  (2008-09-10)