Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane

Stable Identifier
R-HSA-376851
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial inner membrane, mitochondrial matrix
Synonyms
malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] <=> malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol]
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Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane
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The SLC25A11 transport protein in the inner mitochondrial membrane mediates the reversible exchange of mitochondrial alpha-ketoglutarate (2-oxoglutarate) and cytosolic malate. Qualitative evidence for this process comes from studies of the human protein (Kabe et al. 2006); kinetic details are inferred from studies of rat mitochondria under conditions in which only the one transport protein appears to be active (Sluse et al. 1973). The dimeric state of the transport protein is inferred from studies of its bovine homologue (Bisaccia et al. 1996).

Literature References
PubMed ID Title Journal Year
8597574 The formation of a disulfide cross-link between the two subunits demonstrates the dimeric structure of the mitochondrial oxoglutarate carrier

Mazzeo, M, Bisaccia, F, Capobianco, L, Zara, V, Palmieri, F, Iacobazzi, V

Biochim Biophys Acta 1996
16920706 Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier

Azuma, M, Watanabe, H, Ohmori, M, Hirao, S, Handa, H, Sinouchi, K, Okura, I, Kabe, Y, Tsuboi, Y

J Biol Chem 2006
4687397 Mechanism of the exchanges catalysed by the oxoglutarate translocator of rat-heart mitochondria. Kinetics of the external-product inhibition

Sluse, FE, Goffart, G, Liébecq, C

Eur J Biochem 1973
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Event Information
Reverse Reaction
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Homo sapiens)
Catalyst Activity

oxoglutarate:malate antiporter activity of SLC25A11 homodimer [mitochondrial inner membrane]

Physical Entity
SLC25A11 homodimer [mitochondrial inner membrane] (Homo sapiens)
Activity
oxoglutarate:malate antiporter activity (GO:0015367)
Orthologous Events
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Bos taurus)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Caenorhabditis elegans)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Canis familiaris)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Danio rerio)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Dictyostelium discoideum)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Drosophila melanogaster)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Gallus gallus)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Mus musculus)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Rattus norvegicus)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Sus scrofa)
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Xenopus tropicalis)
Authored
D'Eustachio, P  (2008-09-13)
Reviewed
Harris, RA  (2008-09-10)
Created
D'Eustachio, P  (2008-09-10)
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