OAT2 and OAT4 mediate transport of sulphate conjugates

Stable Identifier
R-HSA-561059
Type
Reaction [transition]
Species
Homo sapiens
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The human gene SLC22A7 encodes organic anion transporter 2 (OAT2) and is highly expressed in the liver and kidney (Sun W et al, 2001; Kobayashi Y et al, 2005). The human gene SLC22A11 encodes organic anion transporter 4 (OAT4) which is highly expressed in the placenta and kidney (Cha SH et al, 2000; Ekaratanawong S et al, 2004). Both of these transporters mediate the influx of sulfate conjugates with antiport of dicarboxylic acid. OAT2 is classified as both a transporter of organic anions and sulphate conjugates.

Literature References
PubMed ID Title Journal Year
15901346 Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7])

Kobayashi, Y, Ohshiro, N, Sakai, R, Ohbayashi, M, Kohyama, N, Yamamoto, T

J Pharm Pharmacol 2005
11327718 Isolation of a family of organic anion transporters from human liver and kidney

Sun, W, Wu, RR, van Poelje, PD, Erion, MD

Biochem Biophys Res Commun 2001
15037815 Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules

Ekaratanawong, S, Anzai, N, Jutabha, P, Miyazaki, H, Noshiro, R, Takeda, M, Kanai, Y, Sophasan, S, Endou, H

J Pharmacol Sci 2004
10660625 Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta

Cha, SH, Sekine, T, Kusuhara, H, Yu, E, Kim, JY, Kim, DK, Sugiyama, Y, Kanai, Y, Endou, H

J Biol Chem 2000
Participants
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Catalyst Activity
Title
sodium-independent organic anion transmembrane transporter activity of OAT2/4 [plasma membrane]
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Activity
Orthologous Events
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