OAT2 and OAT4 mediate transport of sulphate conjugates

Stable Identifier
Reaction [transition]
Homo sapiens
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The human gene SLC22A7 encodes organic anion transporter 2 (OAT2) and is highly expressed in the liver and kidney (Sun W et al, 2001; Kobayashi Y et al, 2005). The human gene SLC22A11 encodes organic anion transporter 4 (OAT4) which is highly expressed in the placenta and kidney (Cha SH et al, 2000; Ekaratanawong S et al, 2004). Both of these transporters mediate the influx of sulfate conjugates with antiport of dicarboxylic acid. OAT2 is classified as both a transporter of organic anions and sulphate conjugates.
Literature References
PubMed ID Title Journal Year
11327718 Isolation of a family of organic anion transporters from human liver and kidney

Wu, RR, Sun, W, van Poelje, PD, Erion, MD

Biochem Biophys Res Commun 2001
15901346 Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7])

Ohshiro, N, Kobayashi, Y, Yamamoto, T, Kohyama, N, Sakai, R, Ohbayashi, M

J Pharm Pharmacol 2005
15037815 Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules

Miyazaki, H, Endou, H, Noshiro, R, Jutabha, P, Ekaratanawong, S, Anzai, N, Kanai, Y, Takeda, M, Sophasan, S

J Pharmacol Sci 2004
10660625 Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta

Cha, SH, Endou, H, Yu, E, Kim, DK, Kusuhara, H, Kanai, Y, Sugiyama, Y, Kim, JY, Sekine, T

J Biol Chem 2000
Catalyst Activity

sodium-independent organic anion transmembrane transporter activity of OAT2/4 [plasma membrane]

Orthologous Events
Cross References
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