Reactome | Cytosolic PHD2,3 hydroxylates proline residues on HIF3A

Cytosolic PHD2,3 hydroxylates proline residues on HIF3A

Stable Identifier

R-HSA-1234173

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cytosolic PHD2,3 hydroxylates proline residues on HIF3A

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Proline hydroxylases PHD2 (EGLN1) and PHD3 (EGLN3) located in the cytosol (Metzen et al. 2003) hydroxylate HIF3A at proline-492 (Hirsila et al. 2003, Maynard et al. 2003). A portion of PHD3 (EGLN3) is also located in the nucleus (Rantanen et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
12538644	Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex Maynard, MA, Qi, H, Chung, J, Lee, EH, Kondo, Y, Hara, S, Conaway, RC, Conaway, JW, Ohh, M	J Biol Chem	2003
18337469	Prolyl hydroxylase PHD3 activates oxygen-dependent protein aggregation Rantanen, K, Pursiheimo, J, Högel, H, Himanen, V, Metzen, E, Jaakkola, PM	Mol. Biol. Cell	2008
12615973	Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing Metzen, E, Berchner-Pfannschmidt, U, Stengel, P, Marxsen, JH, Stolze, I, Klinger, M, Huang, WQ, Wotzlaw, C, Hellwig-Bürgel, T, Jelkmann, W, Acker, H, Fandrey, J	J Cell Sci	2003
12788921	Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor Hirsilä, M, Koivunen, P, Günzler, V, Kivirikko, KI, Myllyharju, J	J Biol Chem	2003