isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+

Stable Identifier
R-HSA-389540
Type
Reaction
Species
Homo sapiens
Compartment
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Cytosolic IDH1 (isocitrate dehydrogenase 1) homodimer catalyzes the reaction of isocitrate and NADP+ to form 2-oxoglutarate, CO2, and NADPH + H+. The same enzyme can also localize to peroxisomes (Geisbrecht and Gould 1999; Xu et al. 2004).

Literature References
PubMed ID Title Journal Year
10521434 The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase

Geisbrecht, BV, Gould, SJ

J Biol Chem 1999
15173171 Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity

Ding, J, Xu, X, Arnold, E, Huang, Q, Xu, Z, Zhao, J, Peng, B

J Biol Chem 2004
Participants
Participates
Catalyst Activity

isocitrate dehydrogenase (NADP+) activity of IDH1 dimer [cytosol]

Orthologous Events
Cross References
Rhea
Authored
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Created
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