malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]

Stable Identifier
R-HSA-198440
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial inner membrane, mitochondrial matrix
Synonyms
Exchange of malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane
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malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]
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The SLC25A11 transport protein in the inner mitochondrial membrane mediates the reversible exchange of mitochondrial malate and cytosolic alpha-ketoglutarate (2-oxoglutarate). Qualitative evidence for this process comes from studies of the human protein (Kabe et al. 2006); kinetic details are inferred from stdies of rat mitochondria under conditions in which only the one transport protein appears to be active (Sluse et al. 1973). The dimeric state of the transport protein is inferred from studies of its bovine homologue (Bisaccia et al. 1996).

Literature References
PubMed ID Title Journal Year
8597574 The formation of a disulfide cross-link between the two subunits demonstrates the dimeric structure of the mitochondrial oxoglutarate carrier

Bisaccia, F, Zara, V, Capobianco, L, Iacobazzi, V, Mazzeo, M, Palmieri, F

Biochim Biophys Acta 1996
16920706 Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier

Kabe, Y, Ohmori, M, Sinouchi, K, Tsuboi, Y, Hirao, S, Azuma, M, Watanabe, H, Okura, I, Handa, H

J Biol Chem 2006
4687397 Mechanism of the exchanges catalysed by the oxoglutarate translocator of rat-heart mitochondria. Kinetics of the external-product inhibition

Sluse, FE, Goffart, G, Liébecq, C

Eur J Biochem 1973
Participants
Input
Output
Participant Of
hasEvent
Event Information
Reverse Reaction
Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane (Homo sapiens)
Catalyst Activity
Catalyst Activity
Title
oxoglutarate:malate antiporter activity of SLC25A11 homodimer [mitochondrial inner membrane]
Physical Entity
SLC25A11 homodimer [mitochondrial inner membrane]
Activity
oxoglutarate:malate antiporter activity (0015367)
Orthologous Events
2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix] (Gallus gallus)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Bos taurus)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Caenorhabditis elegans)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Canis familiaris)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Danio rerio)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Dictyostelium discoideum)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Drosophila melanogaster)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Gallus gallus)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Mus musculus)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Plasmodium falciparum)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Rattus norvegicus)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Sus scrofa)
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix] (Xenopus tropicalis)
Authored
D'Eustachio, P  (2007-06-22)
Reviewed
Harris, RA  (2008-09-10)
Created
D'Eustachio, P  (2007-06-22)