leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]

Stable Identifier
Homo sapiens
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Cytosolic branched-chain-amino-acid aminotransferase (BCAT1) catalyzes the reversible reactions of leucine, isoleucine, or valine with alpha-ketoglutarate (2-oxoglutarate) to form alpha-ketoisocaproate, alpha-keto-beta-methylvalerate, or a-ketoisovalerate, respectively, and glutamate. The active enzyme is a homodimer. Goto et al. (2005) have argued that cytosolic BCAT1 plays a major role in the generation of glutamate involved in synaptic transmission in neural tissue.

Literature References
PubMed ID Title Journal Year
16141215 Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin

Hirotsu, K, Goto, M, Islam, MM, Conway, ME, Hutson, SM, Yennawar, NH, Miyahara, I

J Biol Chem 2005
Catalyst Activity

branched-chain-amino-acid transaminase activity of BCAT1 dimer [cytosol]

Orthologous Events
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