leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]

Stable Identifier
R-HSA-70723
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic branched-chain-amino-acid aminotransferase (BCAT1) catalyzes the reversible reactions of leucine, isoleucine, or valine with alpha-ketoglutarate (2-oxoglutarate) to form alpha-ketoisocaproate, alpha-keto-beta-methylvalerate, or a-ketoisovalerate, respectively, and glutamate. The active enzyme is a homodimer. Hutson and colleagues have argues that cytosolic BCAT1 plays a major role in the generation of glutamate involved in synaptic transmission in neural tissue (Goto et al. 2005).

Literature References
PubMed ID Title Journal Year
16141215 Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin

Goto, M, Miyahara, I, Hirotsu, K, Conway, ME, Yennawar, NH, Islam, MM, Hutson, SM

J Biol Chem 2005
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
branched-chain-amino-acid transaminase activity of BCAT1 dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea