Reactome | JMJD4:Fe2+ hydroxylates a lysine residue of ETF1

JMJD4:Fe2+ hydroxylates a lysine residue of ETF1

Stable Identifier

R-HSA-9629946

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

2-oxoglutarate + L-lysyl-(protein) + O2 => 4-hydroxy-L-lysyl-(protein) + CO2 + succinate

ReviewStatus

3/5

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JMJD4:Fe2+ hydroxylates a lysine residue of ETF1

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Cytosolic JMJD4 (JmjC domain-containing protein 4) catalyzes the 4-hydroxlation of lysine-63 residue of ETF1 (eukaryotic peptide chain release factor subunit 1, also known as eRF1). This hydroxylation substantially increases the efficiency with which ETF1 recognizes stop codons (Feng et al. 2014). The catalytically active form of JMJD4 is associated with a Fe2+ ion.

Literature References

PubMed ID	Title	Journal	Year
24486019	Optimal translational termination requires C4 lysyl hydroxylation of eRF1 Trudgian, DC, Hopkinson, RJ, Shelley, J, Coleman, ML, Fischer, R, Feng, T, Schödel, J, Münzel, M, Ge, W, Yates, LA, Gilbert, RJ, Sokolova, E, Yamamoto, A, Alkalaeva, E, Singh, P, Kessler, BM, Cockman, ME, Frolova, LY, Ratcliffe, PJ, McCullagh, JS, Schofield, CJ, Wilkins, SE	Mol. Cell	2014