Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane

Stable Identifier
R-HSA-390347
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal membrane
ReviewStatus
5/5
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Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane
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A specific transport process that exchanges 2-oxoglutarate for isocitrate across a lipid membrane has been reconstituted in vitro with proteins purified from bovine peroxisomal membranes. The specific protein or proteins that mediate this transport process have not yet been identified in any mammalian system, however (Visser et al. 2006).
Literature References
PubMed ID Title Journal Year
16919238 First identification of a 2-ketoglutarate/isocitrate transport system in mammalian peroxisomes and its characterization

Hellingwerf, KJ, IJlst, L, Visser, WF, van Roermund, CW, Waterham, HR

Biochem Biophys Res Commun 2006
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Catalyst Activity

carboxylic acid transmembrane transporter activity of isocitrate-oxoglutarate transporter [peroxisomal membrane]

Physical Entity
isocitrate-oxoglutarate transporter [peroxisomal membrane] (Homo sapiens)
Activity
carboxylic acid transmembrane transporter activity (GO:0046943)
Authored
D'Eustachio, P  (2009-01-08)
Reviewed
Jassal, B  (2009-02-27)
Created
D'Eustachio, P  (2009-01-26)
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