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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
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Analysis Tools
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Analysis Gene Expression
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2OG [mitochondrial matrix]
Stable Identifier
R-ALL-113594
Type
Chemical Compound [SimpleEntity]
Compartment
mitochondrial matrix
Synonyms
2-Oxoglutarate, 2-oxoglutaric acid, Oxoglutaric acid, 2-Ketoglutaric acid, alpha-Ketoglutaric acid, 2-oxoglutarate(2-)
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Aerobic respiration and respiratory electron transport (Bos taurus)
Citric acid cycle (TCA cycle) (Bos taurus)
IDH2 dimer decarboxylates isocitrate (Bos taurus)
2OG [mitochondrial matrix]
IDH3 complex decarboxylates isocitrate (Bos taurus)
2OG [mitochondrial matrix]
OGDH complex synthesizes succinyl-CoA from 2-OG (Bos taurus)
OGDH dimer decarboxylates 2-OG (Bos taurus)
2OG [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Bos taurus)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Bos taurus)
2OG [mitochondrial matrix]
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Bos taurus)
2OG [mitochondrial matrix]
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Bos taurus)
2OG [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Bos taurus)
2OG [mitochondrial matrix]
Pyruvate metabolism (Bos taurus)
PC carboxylates PYR to OA (Bos taurus)
2OG [mitochondrial matrix]
Respiratory electron transport (Bos taurus)
Malate-aspartate shuttle (Bos taurus)
GOT2 transaminates OA and L-Glu (Bos taurus)
2OG [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Bos taurus)
2OG [mitochondrial matrix]
Metabolism of amino acids and derivatives (Bos taurus)
Alanine metabolism (Bos taurus)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Bos taurus)
2OG [mitochondrial matrix]
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Bos taurus)
2OG [mitochondrial matrix]
Aspartate and asparagine metabolism (Bos taurus)
GOT2 dimer transaminates L-Asp (Bos taurus)
2OG [mitochondrial matrix]
Branched-chain amino acid catabolism (Bos taurus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Bos taurus)
2OG [mitochondrial matrix]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Bos taurus)
2OG [mitochondrial matrix]
Carnitine synthesis (Bos taurus)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Bos taurus)
2OG [mitochondrial matrix]
Glutamate and glutamine metabolism (Bos taurus)
GOT2 transaminates OA and L-Glu (Bos taurus)
2OG [mitochondrial matrix]
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Bos taurus)
2OG [mitochondrial matrix]
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Bos taurus)
2OG [mitochondrial matrix]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Bos taurus)
2OG [mitochondrial matrix]
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Bos taurus)
2OG [mitochondrial matrix]
Lysine catabolism (Bos taurus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Bos taurus)
2OG [mitochondrial matrix]
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Bos taurus)
2OG [mitochondrial matrix]
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Bos taurus)
2OG [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Bos taurus)
2OG [mitochondrial matrix]
Tryptophan catabolism (Bos taurus)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Bos taurus)
2OG [mitochondrial matrix]
Metabolism of carbohydrates (Bos taurus)
Glucose metabolism (Bos taurus)
Gluconeogenesis (Bos taurus)
PC carboxylates PYR to OA (Bos taurus)
2OG [mitochondrial matrix]
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter release cycle (Bos taurus)
GABA synthesis, release, reuptake and degradation (Bos taurus)
Degradation of GABA (Bos taurus)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Bos taurus)
2OG [mitochondrial matrix]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Bos taurus)
Organic anion transporters (Bos taurus)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Bos taurus)
2OG [mitochondrial matrix]
Metabolism (Caenorhabditis elegans)
Aerobic respiration and respiratory electron transport (Caenorhabditis elegans)
Citric acid cycle (TCA cycle) (Caenorhabditis elegans)
IDH2 dimer decarboxylates isocitrate (Caenorhabditis elegans)
2OG [mitochondrial matrix]
IDH3 complex decarboxylates isocitrate (Caenorhabditis elegans)
2OG [mitochondrial matrix]
OGDH complex synthesizes succinyl-CoA from 2-OG (Caenorhabditis elegans)
OGDH dimer decarboxylates 2-OG (Caenorhabditis elegans)
2OG [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Caenorhabditis elegans)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Caenorhabditis elegans)
2OG [mitochondrial matrix]
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Caenorhabditis elegans)
2OG [mitochondrial matrix]
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Caenorhabditis elegans)
2OG [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Caenorhabditis elegans)
2OG [mitochondrial matrix]
Pyruvate metabolism (Caenorhabditis elegans)
PC carboxylates PYR to OA (Caenorhabditis elegans)
2OG [mitochondrial matrix]
Respiratory electron transport (Caenorhabditis elegans)
Malate-aspartate shuttle (Caenorhabditis elegans)
GOT2 transaminates OA and L-Glu (Caenorhabditis elegans)
2OG [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Caenorhabditis elegans)
2OG [mitochondrial matrix]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Alanine metabolism (Caenorhabditis elegans)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Caenorhabditis elegans)
2OG [mitochondrial matrix]
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Caenorhabditis elegans)
2OG [mitochondrial matrix]
Aspartate and asparagine metabolism (Caenorhabditis elegans)
GOT2 dimer transaminates L-Asp (Caenorhabditis elegans)
2OG [mitochondrial matrix]
Branched-chain amino acid catabolism (Caenorhabditis elegans)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Caenorhabditis elegans)
2OG [mitochondrial matrix]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Caenorhabditis elegans)
2OG [mitochondrial matrix]
Carnitine synthesis (Caenorhabditis elegans)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Caenorhabditis elegans)
2OG [mitochondrial matrix]
Glutamate and glutamine metabolism (Caenorhabditis elegans)
GOT2 transaminates OA and L-Glu (Caenorhabditis elegans)
2OG [mitochondrial matrix]
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Caenorhabditis elegans)
2OG [mitochondrial matrix]
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Caenorhabditis elegans)
2OG [mitochondrial matrix]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Caenorhabditis elegans)
2OG [mitochondrial matrix]
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Caenorhabditis elegans)
2OG [mitochondrial matrix]
Lysine catabolism (Caenorhabditis elegans)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Caenorhabditis elegans)
2OG [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Caenorhabditis elegans)
2OG [mitochondrial matrix]
Metabolism of carbohydrates (Caenorhabditis elegans)
Glucose metabolism (Caenorhabditis elegans)
Gluconeogenesis (Caenorhabditis elegans)
PC carboxylates PYR to OA (Caenorhabditis elegans)
2OG [mitochondrial matrix]
Neuronal System (Caenorhabditis elegans)
Transmission across Chemical Synapses (Caenorhabditis elegans)
Neurotransmitter release cycle (Caenorhabditis elegans)
GABA synthesis, release, reuptake and degradation (Caenorhabditis elegans)
Degradation of GABA (Caenorhabditis elegans)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Caenorhabditis elegans)
2OG [mitochondrial matrix]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of inorganic cations/anions and amino acids/oligopeptides (Caenorhabditis elegans)
Organic anion transporters (Caenorhabditis elegans)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Caenorhabditis elegans)
2OG [mitochondrial matrix]
Metabolism (Canis familiaris)
Aerobic respiration and respiratory electron transport (Canis familiaris)
Citric acid cycle (TCA cycle) (Canis familiaris)
IDH2 dimer decarboxylates isocitrate (Canis familiaris)
2OG [mitochondrial matrix]
IDH3 complex decarboxylates isocitrate (Canis familiaris)
2OG [mitochondrial matrix]
OGDH complex synthesizes succinyl-CoA from 2-OG (Canis familiaris)
OGDH dimer decarboxylates 2-OG (Canis familiaris)
2OG [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Canis familiaris)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Canis familiaris)
2OG [mitochondrial matrix]
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Canis familiaris)
2OG [mitochondrial matrix]
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Canis familiaris)
2OG [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Canis familiaris)
2OG [mitochondrial matrix]
Pyruvate metabolism (Canis familiaris)
PC carboxylates PYR to OA (Canis familiaris)
2OG [mitochondrial matrix]
Respiratory electron transport (Canis familiaris)
Malate-aspartate shuttle (Canis familiaris)
GOT2 transaminates OA and L-Glu (Canis familiaris)
2OG [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Canis familiaris)
2OG [mitochondrial matrix]
Metabolism of amino acids and derivatives (Canis familiaris)
Alanine metabolism (Canis familiaris)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Canis familiaris)
2OG [mitochondrial matrix]
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Canis familiaris)
2OG [mitochondrial matrix]
Aspartate and asparagine metabolism (Canis familiaris)
GOT2 dimer transaminates L-Asp (Canis familiaris)
2OG [mitochondrial matrix]
Branched-chain amino acid catabolism (Canis familiaris)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Canis familiaris)
2OG [mitochondrial matrix]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Canis familiaris)
2OG [mitochondrial matrix]
Carnitine synthesis (Canis familiaris)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Canis familiaris)
2OG [mitochondrial matrix]
Glutamate and glutamine metabolism (Canis familiaris)
GOT2 transaminates OA and L-Glu (Canis familiaris)
2OG [mitochondrial matrix]
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Canis familiaris)
2OG [mitochondrial matrix]
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Canis familiaris)
2OG [mitochondrial matrix]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Canis familiaris)
2OG [mitochondrial matrix]
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Canis familiaris)
2OG [mitochondrial matrix]
Lysine catabolism (Canis familiaris)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Canis familiaris)
2OG [mitochondrial matrix]
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Canis familiaris)
2OG [mitochondrial matrix]
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Canis familiaris)
2OG [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Canis familiaris)
2OG [mitochondrial matrix]
Tryptophan catabolism (Canis familiaris)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Canis familiaris)
2OG [mitochondrial matrix]
Metabolism of carbohydrates (Canis familiaris)
Glucose metabolism (Canis familiaris)
Gluconeogenesis (Canis familiaris)
PC carboxylates PYR to OA (Canis familiaris)
2OG [mitochondrial matrix]
Neuronal System (Canis familiaris)
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter release cycle (Canis familiaris)
GABA synthesis, release, reuptake and degradation (Canis familiaris)
Degradation of GABA (Canis familiaris)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Canis familiaris)
2OG [mitochondrial matrix]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of inorganic cations/anions and amino acids/oligopeptides (Canis familiaris)
Organic anion transporters (Canis familiaris)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Canis familiaris)
2OG [mitochondrial matrix]
Metabolism (Danio rerio)
Aerobic respiration and respiratory electron transport (Danio rerio)
Citric acid cycle (TCA cycle) (Danio rerio)
IDH2 dimer decarboxylates isocitrate (Danio rerio)
2OG [mitochondrial matrix]
OGDH complex synthesizes succinyl-CoA from 2-OG (Danio rerio)
OGDH dimer decarboxylates 2-OG (Danio rerio)
2OG [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Danio rerio)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Danio rerio)
2OG [mitochondrial matrix]
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Danio rerio)
2OG [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Danio rerio)
2OG [mitochondrial matrix]
Pyruvate metabolism (Danio rerio)
PC carboxylates PYR to OA (Danio rerio)
2OG [mitochondrial matrix]
Respiratory electron transport (Danio rerio)
Malate-aspartate shuttle (Danio rerio)
GOT2 transaminates OA and L-Glu (Danio rerio)
2OG [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Danio rerio)
2OG [mitochondrial matrix]
Metabolism of amino acids and derivatives (Danio rerio)
Aspartate and asparagine metabolism (Danio rerio)
GOT2 dimer transaminates L-Asp (Danio rerio)
2OG [mitochondrial matrix]
Branched-chain amino acid catabolism (Danio rerio)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Danio rerio)
2OG [mitochondrial matrix]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Danio rerio)
2OG [mitochondrial matrix]
Glutamate and glutamine metabolism (Danio rerio)
GOT2 transaminates OA and L-Glu (Danio rerio)
2OG [mitochondrial matrix]
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Danio rerio)
2OG [mitochondrial matrix]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Danio rerio)
2OG [mitochondrial matrix]
Lysine catabolism (Danio rerio)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Danio rerio)
2OG [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Danio rerio)
2OG [mitochondrial matrix]
Metabolism of carbohydrates (Danio rerio)
Glucose metabolism (Danio rerio)
Gluconeogenesis (Danio rerio)
PC carboxylates PYR to OA (Danio rerio)
2OG [mitochondrial matrix]
Neuronal System (Danio rerio)
Transmission across Chemical Synapses (Danio rerio)
Neurotransmitter release cycle (Danio rerio)
GABA synthesis, release, reuptake and degradation (Danio rerio)
Degradation of GABA (Danio rerio)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Danio rerio)
2OG [mitochondrial matrix]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of inorganic cations/anions and amino acids/oligopeptides (Danio rerio)
Organic anion transporters (Danio rerio)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Danio rerio)
2OG [mitochondrial matrix]
Metabolism (Dictyostelium discoideum)
Aerobic respiration and respiratory electron transport (Dictyostelium discoideum)
Citric acid cycle (TCA cycle) (Dictyostelium discoideum)
IDH3 complex decarboxylates isocitrate (Dictyostelium discoideum)
2OG [mitochondrial matrix]
OGDH complex synthesizes succinyl-CoA from 2-OG (Dictyostelium discoideum)
OGDH dimer decarboxylates 2-OG (Dictyostelium discoideum)
2OG [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Dictyostelium discoideum)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Dictyostelium discoideum)
2OG [mitochondrial matrix]
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Dictyostelium discoideum)
2OG [mitochondrial matrix]
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Dictyostelium discoideum)
2OG [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Dictyostelium discoideum)
2OG [mitochondrial matrix]
Respiratory electron transport (Dictyostelium discoideum)
Malate-aspartate shuttle (Dictyostelium discoideum)
GOT2 transaminates OA and L-Glu (Dictyostelium discoideum)
2OG [mitochondrial matrix]
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Alanine metabolism (Dictyostelium discoideum)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Dictyostelium discoideum)
2OG [mitochondrial matrix]
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Dictyostelium discoideum)
2OG [mitochondrial matrix]
Aspartate and asparagine metabolism (Dictyostelium discoideum)
GOT2 dimer transaminates L-Asp (Dictyostelium discoideum)
2OG [mitochondrial matrix]
Branched-chain amino acid catabolism (Dictyostelium discoideum)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Dictyostelium discoideum)
2OG [mitochondrial matrix]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Dictyostelium discoideum)
2OG [mitochondrial matrix]
Glutamate and glutamine metabolism (Dictyostelium discoideum)
GOT2 transaminates OA and L-Glu (Dictyostelium discoideum)
2OG [mitochondrial matrix]
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Dictyostelium discoideum)
2OG [mitochondrial matrix]
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Dictyostelium discoideum)
2OG [mitochondrial matrix]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Dictyostelium discoideum)
2OG [mitochondrial matrix]
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Dictyostelium discoideum)
2OG [mitochondrial matrix]
Lysine catabolism (Dictyostelium discoideum)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Dictyostelium discoideum)
2OG [mitochondrial matrix]
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Dictyostelium discoideum)
2OG [mitochondrial matrix]
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Dictyostelium discoideum)
2OG [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Dictyostelium discoideum)
2OG [mitochondrial matrix]
Tryptophan catabolism (Dictyostelium discoideum)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Dictyostelium discoideum)
2OG [mitochondrial matrix]
Neuronal System (Dictyostelium discoideum)
Transmission across Chemical Synapses (Dictyostelium discoideum)
Neurotransmitter release cycle (Dictyostelium discoideum)
GABA synthesis, release, reuptake and degradation (Dictyostelium discoideum)
Degradation of GABA (Dictyostelium discoideum)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Dictyostelium discoideum)
2OG [mitochondrial matrix]
Metabolism (Drosophila melanogaster)
Aerobic respiration and respiratory electron transport (Drosophila melanogaster)
Citric acid cycle (TCA cycle) (Drosophila melanogaster)
IDH3 complex decarboxylates isocitrate (Drosophila melanogaster)
2OG [mitochondrial matrix]
OGDH complex synthesizes succinyl-CoA from 2-OG (Drosophila melanogaster)
OGDH dimer decarboxylates 2-OG (Drosophila melanogaster)
2OG [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Drosophila melanogaster)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Drosophila melanogaster)
2OG [mitochondrial matrix]
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Drosophila melanogaster)
2OG [mitochondrial matrix]
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Drosophila melanogaster)
2OG [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Drosophila melanogaster)
2OG [mitochondrial matrix]
Pyruvate metabolism (Drosophila melanogaster)
PC carboxylates PYR to OA (Drosophila melanogaster)
2OG [mitochondrial matrix]
Respiratory electron transport (Drosophila melanogaster)
Malate-aspartate shuttle (Drosophila melanogaster)
GOT2 transaminates OA and L-Glu (Drosophila melanogaster)
2OG [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Drosophila melanogaster)
2OG [mitochondrial matrix]
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Alanine metabolism (Drosophila melanogaster)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Drosophila melanogaster)
2OG [mitochondrial matrix]
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Drosophila melanogaster)
2OG [mitochondrial matrix]
Aspartate and asparagine metabolism (Drosophila melanogaster)
GOT2 dimer transaminates L-Asp (Drosophila melanogaster)
2OG [mitochondrial matrix]
Branched-chain amino acid catabolism (Drosophila melanogaster)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Drosophila melanogaster)
2OG [mitochondrial matrix]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Drosophila melanogaster)
2OG [mitochondrial matrix]
Carnitine synthesis (Drosophila melanogaster)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Drosophila melanogaster)
2OG [mitochondrial matrix]
Glutamate and glutamine metabolism (Drosophila melanogaster)
GOT2 transaminates OA and L-Glu (Drosophila melanogaster)
2OG [mitochondrial matrix]
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Drosophila melanogaster)
2OG [mitochondrial matrix]
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Drosophila melanogaster)
2OG [mitochondrial matrix]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Drosophila melanogaster)
2OG [mitochondrial matrix]
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Drosophila melanogaster)
2OG [mitochondrial matrix]
Lysine catabolism (Drosophila melanogaster)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Drosophila melanogaster)
2OG [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Drosophila melanogaster)
2OG [mitochondrial matrix]
Metabolism of carbohydrates (Drosophila melanogaster)
Glucose metabolism (Drosophila melanogaster)
Gluconeogenesis (Drosophila melanogaster)
PC carboxylates PYR to OA (Drosophila melanogaster)
2OG [mitochondrial matrix]
Neuronal System (Drosophila melanogaster)
Transmission across Chemical Synapses (Drosophila melanogaster)
Neurotransmitter release cycle (Drosophila melanogaster)
GABA synthesis, release, reuptake and degradation (Drosophila melanogaster)
Degradation of GABA (Drosophila melanogaster)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Drosophila melanogaster)
2OG [mitochondrial matrix]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of inorganic cations/anions and amino acids/oligopeptides (Drosophila melanogaster)
Organic anion transporters (Drosophila melanogaster)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Drosophila melanogaster)
2OG [mitochondrial matrix]
Metabolism (Gallus gallus)
Amino acid metabolism (Gallus gallus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Gallus gallus)
2OG [mitochondrial matrix]
aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)
2OG [mitochondrial matrix]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) (Gallus gallus)
2OG [mitochondrial matrix]
Carbohydrate metabolism (Gallus gallus)
Gluconeogenesis (Gallus gallus)
2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix] (Gallus gallus)
2OG [mitochondrial matrix]
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) (Gallus gallus)
2OG [mitochondrial matrix]
The tricarboxylic acid cycle (Gallus gallus)
2-oxoglutarate (alpha-ketoglutarate) + CoASH + NAD+ => succinylCoA + CO2 + NADH + H+ (Gallus gallus)
2OG [mitochondrial matrix]
isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+ (Gallus gallus)
2OG [mitochondrial matrix]
Neuronal System (Gallus gallus)
Transmission across Chemical Synapses (Gallus gallus)
Neurotransmitter release cycle (Gallus gallus)
GABA synthesis, release, reuptake and degradation (Gallus gallus)
Degradation of GABA (Gallus gallus)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Gallus gallus)
2OG [mitochondrial matrix]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Gallus gallus)
Organic anion transporters (Gallus gallus)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Gallus gallus)
2OG [mitochondrial matrix]
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
IDH2 dimer decarboxylates isocitrate (Homo sapiens)
2OG [mitochondrial matrix]
IDH3 complex decarboxylates isocitrate (Homo sapiens)
2OG [mitochondrial matrix]
OGDH complex synthesizes succinyl-CoA from 2-OG (Homo sapiens)
OGDH dimer decarboxylates 2-OG (Homo sapiens)
2OG [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Homo sapiens)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Homo sapiens)
2OG [mitochondrial matrix]
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Homo sapiens)
2OG [mitochondrial matrix]
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Homo sapiens)
2OG [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Homo sapiens)
2OG [mitochondrial matrix]
Pyruvate metabolism (Homo sapiens)
PC carboxylates PYR to OA (Homo sapiens)
2OG [mitochondrial matrix]
Respiratory electron transport (Homo sapiens)
Malate-aspartate shuttle (Homo sapiens)
GOT2 transaminates OA and L-Glu (Homo sapiens)
2OG [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Homo sapiens)
2OG [mitochondrial matrix]
Metabolism of amino acids and derivatives (Homo sapiens)
Alanine metabolism (Homo sapiens)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Homo sapiens)
2OG [mitochondrial matrix]
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Homo sapiens)
2OG [mitochondrial matrix]
Aspartate and asparagine metabolism (Homo sapiens)
GOT2 dimer transaminates L-Asp (Homo sapiens)
2OG [mitochondrial matrix]
Branched-chain amino acid catabolism (Homo sapiens)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Homo sapiens)
2OG [mitochondrial matrix]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Homo sapiens)
2OG [mitochondrial matrix]
Carnitine synthesis (Homo sapiens)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Homo sapiens)
2OG [mitochondrial matrix]
Glutamate and glutamine metabolism (Homo sapiens)
GOT2 transaminates OA and L-Glu (Homo sapiens)
2OG [mitochondrial matrix]
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Homo sapiens)
2OG [mitochondrial matrix]
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Homo sapiens)
2OG [mitochondrial matrix]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Homo sapiens)
2OG [mitochondrial matrix]
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Homo sapiens)
2OG [mitochondrial matrix]
Lysine catabolism (Homo sapiens)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Homo sapiens)
2OG [mitochondrial matrix]
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Homo sapiens)
2OG [mitochondrial matrix]
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Homo sapiens)
2OG [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Homo sapiens)
2OG [mitochondrial matrix]
Sulfur amino acid metabolism (Homo sapiens)
Degradation of cysteine and homocysteine (Homo sapiens)
GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu (Homo sapiens)
2OG [mitochondrial matrix]
Tryptophan catabolism (Homo sapiens)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Homo sapiens)
2OG [mitochondrial matrix]
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Gluconeogenesis (Homo sapiens)
PC carboxylates PYR to OA (Homo sapiens)
2OG [mitochondrial matrix]
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
GABA synthesis, release, reuptake and degradation (Homo sapiens)
Degradation of GABA (Homo sapiens)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Homo sapiens)
2OG [mitochondrial matrix]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Organic anion transporters (Homo sapiens)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Homo sapiens)
2OG [mitochondrial matrix]
Metabolism (Mus musculus)
Aerobic respiration and respiratory electron transport (Mus musculus)
Citric acid cycle (TCA cycle) (Mus musculus)
IDH2 dimer decarboxylates isocitrate (Mus musculus)
2OG [mitochondrial matrix]
IDH3 complex decarboxylates isocitrate (Mus musculus)
2OG [mitochondrial matrix]
OGDH complex synthesizes succinyl-CoA from 2-OG (Mus musculus)
OGDH dimer decarboxylates 2-OG (Mus musculus)
2OG [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Mus musculus)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Mus musculus)
2OG [mitochondrial matrix]
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Mus musculus)
2OG [mitochondrial matrix]
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Mus musculus)
2OG [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Mus musculus)
2OG [mitochondrial matrix]
Pyruvate metabolism (Mus musculus)
PC carboxylates PYR to OA (Mus musculus)
2OG [mitochondrial matrix]
Respiratory electron transport (Mus musculus)
Malate-aspartate shuttle (Mus musculus)
GOT2 transaminates OA and L-Glu (Mus musculus)
2OG [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Mus musculus)
2OG [mitochondrial matrix]
Metabolism of amino acids and derivatives (Mus musculus)
Alanine metabolism (Mus musculus)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Mus musculus)
2OG [mitochondrial matrix]
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Mus musculus)
2OG [mitochondrial matrix]
Aspartate and asparagine metabolism (Mus musculus)
GOT2 dimer transaminates L-Asp (Mus musculus)
2OG [mitochondrial matrix]
Branched-chain amino acid catabolism (Mus musculus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Mus musculus)
2OG [mitochondrial matrix]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Mus musculus)
2OG [mitochondrial matrix]
Carnitine synthesis (Mus musculus)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Mus musculus)
2OG [mitochondrial matrix]
Glutamate and glutamine metabolism (Mus musculus)
GOT2 transaminates OA and L-Glu (Mus musculus)
2OG [mitochondrial matrix]
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Mus musculus)
2OG [mitochondrial matrix]
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Mus musculus)
2OG [mitochondrial matrix]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Mus musculus)
2OG [mitochondrial matrix]
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Mus musculus)
2OG [mitochondrial matrix]
Lysine catabolism (Mus musculus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Mus musculus)
2OG [mitochondrial matrix]
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Mus musculus)
2OG [mitochondrial matrix]
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Mus musculus)
2OG [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Mus musculus)
2OG [mitochondrial matrix]
Tryptophan catabolism (Mus musculus)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Mus musculus)
2OG [mitochondrial matrix]
Metabolism of carbohydrates (Mus musculus)
Glucose metabolism (Mus musculus)
Gluconeogenesis (Mus musculus)
PC carboxylates PYR to OA (Mus musculus)
2OG [mitochondrial matrix]
Neuronal System (Mus musculus)
Transmission across Chemical Synapses (Mus musculus)
Neurotransmitter release cycle (Mus musculus)
GABA synthesis, release, reuptake and degradation (Mus musculus)
Degradation of GABA (Mus musculus)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Mus musculus)
2OG [mitochondrial matrix]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Mus musculus)
Organic anion transporters (Mus musculus)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Mus musculus)
2OG [mitochondrial matrix]
Metabolism (Plasmodium falciparum)
Aerobic respiration and respiratory electron transport (Plasmodium falciparum)
Citric acid cycle (TCA cycle) (Plasmodium falciparum)
IDH2 dimer decarboxylates isocitrate (Plasmodium falciparum)
2OG [mitochondrial matrix]
OGDH complex synthesizes succinyl-CoA from 2-OG (Plasmodium falciparum)
OGDH dimer decarboxylates 2-OG (Plasmodium falciparum)
2OG [mitochondrial matrix]
Respiratory electron transport (Plasmodium falciparum)
Malate-aspartate shuttle (Plasmodium falciparum)
SLC25A11 exchanges 2-OG and MAL (Plasmodium falciparum)
2OG [mitochondrial matrix]
Metabolism of amino acids and derivatives (Plasmodium falciparum)
Glutamate and glutamine metabolism (Plasmodium falciparum)
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Plasmodium falciparum)
2OG [mitochondrial matrix]
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Plasmodium falciparum)
2OG [mitochondrial matrix]
Transport of small molecules (Plasmodium falciparum)
SLC-mediated transmembrane transport (Plasmodium falciparum)
Transport of inorganic cations/anions and amino acids/oligopeptides (Plasmodium falciparum)
Organic anion transporters (Plasmodium falciparum)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Plasmodium falciparum)
2OG [mitochondrial matrix]
Metabolism (Rattus norvegicus)
Aerobic respiration and respiratory electron transport (Rattus norvegicus)
Citric acid cycle (TCA cycle) (Rattus norvegicus)
IDH2 dimer decarboxylates isocitrate (Rattus norvegicus)
2OG [mitochondrial matrix]
IDH3 complex decarboxylates isocitrate (Rattus norvegicus)
2OG [mitochondrial matrix]
OGDH complex synthesizes succinyl-CoA from 2-OG (Rattus norvegicus)
OGDH dimer decarboxylates 2-OG (Rattus norvegicus)
2OG [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Rattus norvegicus)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Rattus norvegicus)
2OG [mitochondrial matrix]
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Rattus norvegicus)
2OG [mitochondrial matrix]
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Rattus norvegicus)
2OG [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Rattus norvegicus)
2OG [mitochondrial matrix]
Pyruvate metabolism (Rattus norvegicus)
PC carboxylates PYR to OA (Rattus norvegicus)
2OG [mitochondrial matrix]
Respiratory electron transport (Rattus norvegicus)
Malate-aspartate shuttle (Rattus norvegicus)
GOT2 transaminates OA and L-Glu (Rattus norvegicus)
2OG [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Rattus norvegicus)
2OG [mitochondrial matrix]
Metabolism of amino acids and derivatives (Rattus norvegicus)
Alanine metabolism (Rattus norvegicus)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Rattus norvegicus)
2OG [mitochondrial matrix]
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Rattus norvegicus)
2OG [mitochondrial matrix]
Aspartate and asparagine metabolism (Rattus norvegicus)
GOT2 dimer transaminates L-Asp (Rattus norvegicus)
2OG [mitochondrial matrix]
Branched-chain amino acid catabolism (Rattus norvegicus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Rattus norvegicus)
2OG [mitochondrial matrix]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Rattus norvegicus)
2OG [mitochondrial matrix]
Carnitine synthesis (Rattus norvegicus)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Rattus norvegicus)
2OG [mitochondrial matrix]
Glutamate and glutamine metabolism (Rattus norvegicus)
GOT2 transaminates OA and L-Glu (Rattus norvegicus)
2OG [mitochondrial matrix]
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Rattus norvegicus)
2OG [mitochondrial matrix]
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Rattus norvegicus)
2OG [mitochondrial matrix]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Rattus norvegicus)
2OG [mitochondrial matrix]
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Rattus norvegicus)
2OG [mitochondrial matrix]
Lysine catabolism (Rattus norvegicus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Rattus norvegicus)
2OG [mitochondrial matrix]
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Rattus norvegicus)
2OG [mitochondrial matrix]
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Rattus norvegicus)
2OG [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Rattus norvegicus)
2OG [mitochondrial matrix]
Tryptophan catabolism (Rattus norvegicus)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Rattus norvegicus)
2OG [mitochondrial matrix]
Metabolism of carbohydrates (Rattus norvegicus)
Glucose metabolism (Rattus norvegicus)
Gluconeogenesis (Rattus norvegicus)
PC carboxylates PYR to OA (Rattus norvegicus)
2OG [mitochondrial matrix]
Neuronal System (Rattus norvegicus)
Transmission across Chemical Synapses (Rattus norvegicus)
Neurotransmitter release cycle (Rattus norvegicus)
GABA synthesis, release, reuptake and degradation (Rattus norvegicus)
Degradation of GABA (Rattus norvegicus)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Rattus norvegicus)
2OG [mitochondrial matrix]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of inorganic cations/anions and amino acids/oligopeptides (Rattus norvegicus)
Organic anion transporters (Rattus norvegicus)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Rattus norvegicus)
2OG [mitochondrial matrix]
Metabolism (Saccharomyces cerevisiae)
Aerobic respiration and respiratory electron transport (Saccharomyces cerevisiae)
Citric acid cycle (TCA cycle) (Saccharomyces cerevisiae)
IDH3 complex decarboxylates isocitrate (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
OGDH complex synthesizes succinyl-CoA from 2-OG (Saccharomyces cerevisiae)
OGDH dimer decarboxylates 2-OG (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Saccharomyces cerevisiae)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
Pyruvate metabolism (Saccharomyces cerevisiae)
PC carboxylates PYR to OA (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
Respiratory electron transport (Saccharomyces cerevisiae)
Malate-aspartate shuttle (Saccharomyces cerevisiae)
GOT2 transaminates OA and L-Glu (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
Metabolism of amino acids and derivatives (Saccharomyces cerevisiae)
Alanine metabolism (Saccharomyces cerevisiae)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
Aspartate and asparagine metabolism (Saccharomyces cerevisiae)
GOT2 dimer transaminates L-Asp (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
Branched-chain amino acid catabolism (Saccharomyces cerevisiae)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
Glutamate and glutamine metabolism (Saccharomyces cerevisiae)
GOT2 transaminates OA and L-Glu (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
Lysine catabolism (Saccharomyces cerevisiae)
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
Tryptophan catabolism (Saccharomyces cerevisiae)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
Metabolism of carbohydrates (Saccharomyces cerevisiae)
Glucose metabolism (Saccharomyces cerevisiae)
Gluconeogenesis (Saccharomyces cerevisiae)
PC carboxylates PYR to OA (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
Neuronal System (Saccharomyces cerevisiae)
Transmission across Chemical Synapses (Saccharomyces cerevisiae)
Neurotransmitter release cycle (Saccharomyces cerevisiae)
GABA synthesis, release, reuptake and degradation (Saccharomyces cerevisiae)
Degradation of GABA (Saccharomyces cerevisiae)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Saccharomyces cerevisiae)
2OG [mitochondrial matrix]
Metabolism (Schizosaccharomyces pombe)
Aerobic respiration and respiratory electron transport (Schizosaccharomyces pombe)
Citric acid cycle (TCA cycle) (Schizosaccharomyces pombe)
IDH3 complex decarboxylates isocitrate (Schizosaccharomyces pombe)
2OG [mitochondrial matrix]
OGDH complex synthesizes succinyl-CoA from 2-OG (Schizosaccharomyces pombe)
OGDH dimer decarboxylates 2-OG (Schizosaccharomyces pombe)
2OG [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Schizosaccharomyces pombe)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Schizosaccharomyces pombe)
2OG [mitochondrial matrix]
Pyruvate metabolism (Schizosaccharomyces pombe)
PC carboxylates PYR to OA (Schizosaccharomyces pombe)
2OG [mitochondrial matrix]
Respiratory electron transport (Schizosaccharomyces pombe)
Malate-aspartate shuttle (Schizosaccharomyces pombe)
GOT2 transaminates OA and L-Glu (Schizosaccharomyces pombe)
2OG [mitochondrial matrix]
Metabolism of amino acids and derivatives (Schizosaccharomyces pombe)
Aspartate and asparagine metabolism (Schizosaccharomyces pombe)
GOT2 dimer transaminates L-Asp (Schizosaccharomyces pombe)
2OG [mitochondrial matrix]
Branched-chain amino acid catabolism (Schizosaccharomyces pombe)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Schizosaccharomyces pombe)
2OG [mitochondrial matrix]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Schizosaccharomyces pombe)
2OG [mitochondrial matrix]
Glutamate and glutamine metabolism (Schizosaccharomyces pombe)
GOT2 transaminates OA and L-Glu (Schizosaccharomyces pombe)
2OG [mitochondrial matrix]
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Schizosaccharomyces pombe)
2OG [mitochondrial matrix]
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Schizosaccharomyces pombe)
2OG [mitochondrial matrix]
Lysine catabolism (Schizosaccharomyces pombe)
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Schizosaccharomyces pombe)
2OG [mitochondrial matrix]
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Schizosaccharomyces pombe)
2OG [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Schizosaccharomyces pombe)
2OG [mitochondrial matrix]
Tryptophan catabolism (Schizosaccharomyces pombe)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Schizosaccharomyces pombe)
2OG [mitochondrial matrix]
Metabolism of carbohydrates (Schizosaccharomyces pombe)
Glucose metabolism (Schizosaccharomyces pombe)
Gluconeogenesis (Schizosaccharomyces pombe)
PC carboxylates PYR to OA (Schizosaccharomyces pombe)
2OG [mitochondrial matrix]
Neuronal System (Schizosaccharomyces pombe)
Transmission across Chemical Synapses (Schizosaccharomyces pombe)
Neurotransmitter release cycle (Schizosaccharomyces pombe)
GABA synthesis, release, reuptake and degradation (Schizosaccharomyces pombe)
Degradation of GABA (Schizosaccharomyces pombe)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Schizosaccharomyces pombe)
2OG [mitochondrial matrix]
Metabolism (Sus scrofa)
Aerobic respiration and respiratory electron transport (Sus scrofa)
Citric acid cycle (TCA cycle) (Sus scrofa)
IDH2 dimer decarboxylates isocitrate (Sus scrofa)
2OG [mitochondrial matrix]
IDH3 complex decarboxylates isocitrate (Sus scrofa)
2OG [mitochondrial matrix]
OGDH complex synthesizes succinyl-CoA from 2-OG (Sus scrofa)
OGDH dimer decarboxylates 2-OG (Sus scrofa)
2OG [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Sus scrofa)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Sus scrofa)
2OG [mitochondrial matrix]
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Sus scrofa)
2OG [mitochondrial matrix]
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Sus scrofa)
2OG [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Sus scrofa)
2OG [mitochondrial matrix]
Pyruvate metabolism (Sus scrofa)
PC carboxylates PYR to OA (Sus scrofa)
2OG [mitochondrial matrix]
Respiratory electron transport (Sus scrofa)
Malate-aspartate shuttle (Sus scrofa)
GOT2 transaminates OA and L-Glu (Sus scrofa)
2OG [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Sus scrofa)
2OG [mitochondrial matrix]
Metabolism of amino acids and derivatives (Sus scrofa)
Alanine metabolism (Sus scrofa)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Sus scrofa)
2OG [mitochondrial matrix]
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Sus scrofa)
2OG [mitochondrial matrix]
Aspartate and asparagine metabolism (Sus scrofa)
GOT2 dimer transaminates L-Asp (Sus scrofa)
2OG [mitochondrial matrix]
Branched-chain amino acid catabolism (Sus scrofa)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Sus scrofa)
2OG [mitochondrial matrix]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Sus scrofa)
2OG [mitochondrial matrix]
Carnitine synthesis (Sus scrofa)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Sus scrofa)
2OG [mitochondrial matrix]
Glutamate and glutamine metabolism (Sus scrofa)
GOT2 transaminates OA and L-Glu (Sus scrofa)
2OG [mitochondrial matrix]
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Sus scrofa)
2OG [mitochondrial matrix]
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Sus scrofa)
2OG [mitochondrial matrix]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Sus scrofa)
2OG [mitochondrial matrix]
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Sus scrofa)
2OG [mitochondrial matrix]
Lysine catabolism (Sus scrofa)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Sus scrofa)
2OG [mitochondrial matrix]
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Sus scrofa)
2OG [mitochondrial matrix]
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Sus scrofa)
2OG [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Sus scrofa)
2OG [mitochondrial matrix]
Tryptophan catabolism (Sus scrofa)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Sus scrofa)
2OG [mitochondrial matrix]
Metabolism of carbohydrates (Sus scrofa)
Glucose metabolism (Sus scrofa)
Gluconeogenesis (Sus scrofa)
PC carboxylates PYR to OA (Sus scrofa)
2OG [mitochondrial matrix]
Neuronal System (Sus scrofa)
Transmission across Chemical Synapses (Sus scrofa)
Neurotransmitter release cycle (Sus scrofa)
GABA synthesis, release, reuptake and degradation (Sus scrofa)
Degradation of GABA (Sus scrofa)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Sus scrofa)
2OG [mitochondrial matrix]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of inorganic cations/anions and amino acids/oligopeptides (Sus scrofa)
Organic anion transporters (Sus scrofa)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Sus scrofa)
2OG [mitochondrial matrix]
Metabolism (Xenopus tropicalis)
Aerobic respiration and respiratory electron transport (Xenopus tropicalis)
Citric acid cycle (TCA cycle) (Xenopus tropicalis)
IDH2 dimer decarboxylates isocitrate (Xenopus tropicalis)
2OG [mitochondrial matrix]
OGDH complex synthesizes succinyl-CoA from 2-OG (Xenopus tropicalis)
OGDH dimer decarboxylates 2-OG (Xenopus tropicalis)
2OG [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Xenopus tropicalis)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Xenopus tropicalis)
2OG [mitochondrial matrix]
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Xenopus tropicalis)
2OG [mitochondrial matrix]
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Xenopus tropicalis)
2OG [mitochondrial matrix]
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Xenopus tropicalis)
2OG [mitochondrial matrix]
Pyruvate metabolism (Xenopus tropicalis)
PC carboxylates PYR to OA (Xenopus tropicalis)
2OG [mitochondrial matrix]
Respiratory electron transport (Xenopus tropicalis)
Malate-aspartate shuttle (Xenopus tropicalis)
GOT2 transaminates OA and L-Glu (Xenopus tropicalis)
2OG [mitochondrial matrix]
SLC25A11 exchanges 2-OG and MAL (Xenopus tropicalis)
2OG [mitochondrial matrix]
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Alanine metabolism (Xenopus tropicalis)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Xenopus tropicalis)
2OG [mitochondrial matrix]
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Xenopus tropicalis)
2OG [mitochondrial matrix]
Aspartate and asparagine metabolism (Xenopus tropicalis)
GOT2 dimer transaminates L-Asp (Xenopus tropicalis)
2OG [mitochondrial matrix]
Branched-chain amino acid catabolism (Xenopus tropicalis)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Xenopus tropicalis)
2OG [mitochondrial matrix]
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Xenopus tropicalis)
2OG [mitochondrial matrix]
Carnitine synthesis (Xenopus tropicalis)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Xenopus tropicalis)
2OG [mitochondrial matrix]
Glutamate and glutamine metabolism (Xenopus tropicalis)
GOT2 transaminates OA and L-Glu (Xenopus tropicalis)
2OG [mitochondrial matrix]
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Xenopus tropicalis)
2OG [mitochondrial matrix]
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Xenopus tropicalis)
2OG [mitochondrial matrix]
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Xenopus tropicalis)
2OG [mitochondrial matrix]
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Xenopus tropicalis)
2OG [mitochondrial matrix]
Lysine catabolism (Xenopus tropicalis)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Xenopus tropicalis)
2OG [mitochondrial matrix]
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Xenopus tropicalis)
2OG [mitochondrial matrix]
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Xenopus tropicalis)
2OG [mitochondrial matrix]
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Xenopus tropicalis)
2OG [mitochondrial matrix]
Tryptophan catabolism (Xenopus tropicalis)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Xenopus tropicalis)
2OG [mitochondrial matrix]
Metabolism of carbohydrates (Xenopus tropicalis)
Glucose metabolism (Xenopus tropicalis)
Gluconeogenesis (Xenopus tropicalis)
PC carboxylates PYR to OA (Xenopus tropicalis)
2OG [mitochondrial matrix]
Neuronal System (Xenopus tropicalis)
Transmission across Chemical Synapses (Xenopus tropicalis)
Neurotransmitter release cycle (Xenopus tropicalis)
GABA synthesis, release, reuptake and degradation (Xenopus tropicalis)
Degradation of GABA (Xenopus tropicalis)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Xenopus tropicalis)
2OG [mitochondrial matrix]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of inorganic cations/anions and amino acids/oligopeptides (Xenopus tropicalis)
Organic anion transporters (Xenopus tropicalis)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Xenopus tropicalis)
2OG [mitochondrial matrix]
External Reference Information
External Reference
2-oxoglutarate(2-) [ChEBI:16810]
Participates
as an input of
2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix] (Gallus gallus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Gallus gallus)
aspartate + alpha-ketoglutarate (2-oxoglutarate) <=> oxaloacetate + glutamate (Gallus gallus)
2-oxoglutarate (alpha-ketoglutarate) + CoASH + NAD+ => succinylCoA + CO2 + NADH + H+ (Gallus gallus)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Saccharomyces cerevisiae)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Schizosaccharomyces pombe)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Dictyostelium discoideum)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Gallus gallus)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Xenopus tropicalis)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Bos taurus)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Canis familiaris)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Rattus norvegicus)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Mus musculus)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Homo sapiens)
kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate (Sus scrofa)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Saccharomyces cerevisiae)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Dictyostelium discoideum)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Caenorhabditis elegans)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Drosophila melanogaster)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Gallus gallus)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Xenopus tropicalis)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Bos taurus)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Canis familiaris)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Rattus norvegicus)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Mus musculus)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Homo sapiens)
PXLP-K341-GPT2 transaminates L-Ala to form PYR (Sus scrofa)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Dictyostelium discoideum)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Caenorhabditis elegans)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Drosophila melanogaster)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Gallus gallus)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Xenopus tropicalis)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Danio rerio)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Sus scrofa)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Bos taurus)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Canis familiaris)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Rattus norvegicus)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Mus musculus)
alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2) (Homo sapiens)
Got2:PLXP dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu (Rattus norvegicus)
GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu (Homo sapiens)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Dictyostelium discoideum)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Caenorhabditis elegans)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Drosophila melanogaster)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Gallus gallus)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Xenopus tropicalis)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Danio rerio)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Sus scrofa)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Bos taurus)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Canis familiaris)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Rattus norvegicus)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Mus musculus)
2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde (Homo sapiens)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Caenorhabditis elegans)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Drosophila melanogaster)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Gallus gallus)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Xenopus tropicalis)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Sus scrofa)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Bos taurus)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Canis familiaris)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Rattus norvegicus)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Mus musculus)
TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA (Homo sapiens)
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Plasmodium falciparum)
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Saccharomyces cerevisiae)
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Schizosaccharomyces pombe)
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Dictyostelium discoideum)
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Caenorhabditis elegans)
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Drosophila melanogaster)
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Gallus gallus)
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Xenopus tropicalis)
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Sus scrofa)
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Bos taurus)
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Canis familiaris)
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Rattus norvegicus)
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Mus musculus)
ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT] (Homo sapiens)
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Saccharomyces cerevisiae)
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Schizosaccharomyces pombe)
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Dictyostelium discoideum)
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Gallus gallus)
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Xenopus tropicalis)
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Sus scrofa)
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Bos taurus)
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Canis familiaris)
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Rattus norvegicus)
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Mus musculus)
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Saccharomyces cerevisiae)
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Schizosaccharomyces pombe)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Dictyostelium discoideum)
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Dictyostelium discoideum)
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Caenorhabditis elegans)
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Drosophila melanogaster)
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Danio rerio)
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Bos taurus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Bos taurus)
SLC25A11 exchanges 2-OG and MAL (Bos taurus)
OGDH dimer decarboxylates 2-OG (Saccharomyces cerevisiae)
OGDH dimer decarboxylates 2-OG (Schizosaccharomyces pombe)
SLC25A11 exchanges 2-OG and MAL (Plasmodium falciparum)
OGDH dimer decarboxylates 2-OG (Plasmodium falciparum)
OGDH dimer decarboxylates 2-OG (Dictyostelium discoideum)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Caenorhabditis elegans)
SLC25A11 exchanges 2-OG and MAL (Caenorhabditis elegans)
OGDH dimer decarboxylates 2-OG (Caenorhabditis elegans)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Drosophila melanogaster)
SLC25A11 exchanges 2-OG and MAL (Drosophila melanogaster)
OGDH dimer decarboxylates 2-OG (Drosophila melanogaster)
OGDH dimer decarboxylates 2-OG (Gallus gallus)
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Gallus gallus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Gallus gallus)
SLC25A11 exchanges 2-OG and MAL (Gallus gallus)
OGDH dimer decarboxylates 2-OG (Xenopus tropicalis)
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Xenopus tropicalis)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Xenopus tropicalis)
SLC25A11 exchanges 2-OG and MAL (Xenopus tropicalis)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Danio rerio)
SLC25A11 exchanges 2-OG and MAL (Danio rerio)
OGDH dimer decarboxylates 2-OG (Danio rerio)
OGDH dimer decarboxylates 2-OG (Rattus norvegicus)
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Sus scrofa)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Sus scrofa)
SLC25A11 exchanges 2-OG and MAL (Sus scrofa)
OGDH dimer decarboxylates 2-OG (Sus scrofa)
OGDH dimer decarboxylates 2-OG (Mus musculus)
OGDH dimer decarboxylates 2-OG (Homo sapiens)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Saccharomyces cerevisiae)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Schizosaccharomyces pombe)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Dictyostelium discoideum)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Caenorhabditis elegans)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Drosophila melanogaster)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Xenopus tropicalis)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Danio rerio)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Sus scrofa)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Bos taurus)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Canis familiaris)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Rattus norvegicus)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Homo sapiens)
leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] (Mus musculus)
OGDH dimer decarboxylates 2-OG (Canis familiaris)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Saccharomyces cerevisiae)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Schizosaccharomyces pombe)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Dictyostelium discoideum)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Caenorhabditis elegans)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Drosophila melanogaster)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Gallus gallus)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Xenopus tropicalis)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Danio rerio)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Sus scrofa)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Bos taurus)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Rattus norvegicus)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Mus musculus)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Homo sapiens)
PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA (Canis familiaris)
SLC25A11 exchanges 2-OG and MAL (Canis familiaris)
SLC25A11 exchanges 2-OG and MAL (Homo sapiens)
SLC25A11 exchanges 2-OG and MAL (Mus musculus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Homo sapiens)
GOT2 dimer transaminates L-Asp (Homo sapiens)
GOT2 dimer transaminates L-Asp (Mus musculus)
GOT2 dimer transaminates L-Asp (Rattus norvegicus)
GOT2 dimer transaminates L-Asp (Canis familiaris)
GOT2 dimer transaminates L-Asp (Bos taurus)
GOT2 dimer transaminates L-Asp (Sus scrofa)
GOT2 dimer transaminates L-Asp (Danio rerio)
GOT2 dimer transaminates L-Asp (Xenopus tropicalis)
GOT2 dimer transaminates L-Asp (Gallus gallus)
GOT2 dimer transaminates L-Asp (Drosophila melanogaster)
GOT2 dimer transaminates L-Asp (Caenorhabditis elegans)
GOT2 dimer transaminates L-Asp (Dictyostelium discoideum)
GOT2 dimer transaminates L-Asp (Schizosaccharomyces pombe)
GOT2 dimer transaminates L-Asp (Saccharomyces cerevisiae)
SLC25A11 exchanges 2-OG and MAL (Rattus norvegicus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Canis familiaris)
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Canis familiaris)
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Homo sapiens)
alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate (Homo sapiens)
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Mus musculus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Mus musculus)
lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O (Rattus norvegicus)
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] (Rattus norvegicus)
OGDH dimer decarboxylates 2-OG (Bos taurus)
as an output of
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) (Gallus gallus)
isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+ (Gallus gallus)
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Saccharomyces cerevisiae)
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Dictyostelium discoideum)
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Caenorhabditis elegans)
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Drosophila melanogaster)
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Gallus gallus)
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Xenopus tropicalis)
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Sus scrofa)
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Bos taurus)
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Canis familiaris)
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Rattus norvegicus)
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Mus musculus)
PXLP-K341-GPT2 transaminates PYR to form L-Ala (Homo sapiens)
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Dictyostelium discoideum)
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Caenorhabditis elegans)
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Drosophila melanogaster)
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Gallus gallus)
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Xenopus tropicalis)
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Danio rerio)
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Sus scrofa)
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Canis familiaris)
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Rattus norvegicus)
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Mus musculus)
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Homo sapiens)
glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2) (Bos taurus)
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Dictyostelium discoideum)
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Caenorhabditis elegans)
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Drosophila melanogaster)
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Gallus gallus)
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Xenopus tropicalis)
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Sus scrofa)
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Bos taurus)
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Canis familiaris)
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Rattus norvegicus)
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Mus musculus)
(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Homo sapiens)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Dictyostelium discoideum)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Caenorhabditis elegans)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Drosophila melanogaster)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Gallus gallus)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Xenopus tropicalis)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Danio rerio)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Sus scrofa)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Bos taurus)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Canis familiaris)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Rattus norvegicus)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Mus musculus)
(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (Homo sapiens)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Saccharomyces cerevisiae)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Schizosaccharomyces pombe)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Dictyostelium discoideum)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Caenorhabditis elegans)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Drosophila melanogaster)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Gallus gallus)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Xenopus tropicalis)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Danio rerio)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Sus scrofa)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Bos taurus)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Canis familiaris)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Rattus norvegicus)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Mus musculus)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Homo sapiens)
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Plasmodium falciparum)
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Dictyostelium discoideum)
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Caenorhabditis elegans)
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Drosophila melanogaster)
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Homo sapiens)
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Saccharomyces cerevisiae)
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Schizosaccharomyces pombe)
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Xenopus tropicalis)
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Rattus norvegicus)
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Gallus gallus)
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Canis familiaris)
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Sus scrofa)
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Bos taurus)
glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] (Mus musculus)
GOT2 transaminates OA and L-Glu (Schizosaccharomyces pombe)
GOT2 transaminates OA and L-Glu (Saccharomyces cerevisiae)
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Homo sapiens)
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Saccharomyces cerevisiae)
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Schizosaccharomyces pombe)
GOT2 transaminates OA and L-Glu (Dictyostelium discoideum)
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Dictyostelium discoideum)
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Bos taurus)
IDH2 dimer decarboxylates isocitrate (Bos taurus)
IDH2 dimer decarboxylates isocitrate (Canis familiaris)
IDH3 complex decarboxylates isocitrate (Saccharomyces cerevisiae)
IDH3 complex decarboxylates isocitrate (Schizosaccharomyces pombe)
IDH2 dimer decarboxylates isocitrate (Plasmodium falciparum)
IDH3 complex decarboxylates isocitrate (Dictyostelium discoideum)
IDH2 dimer decarboxylates isocitrate (Caenorhabditis elegans)
GOT2 transaminates OA and L-Glu (Caenorhabditis elegans)
IDH3 complex decarboxylates isocitrate (Caenorhabditis elegans)
GOT2 transaminates OA and L-Glu (Drosophila melanogaster)
IDH3 complex decarboxylates isocitrate (Drosophila melanogaster)
IDH2 dimer decarboxylates isocitrate (Gallus gallus)
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Gallus gallus)
GOT2 transaminates OA and L-Glu (Gallus gallus)
IDH2 dimer decarboxylates isocitrate (Xenopus tropicalis)
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Xenopus tropicalis)
GOT2 transaminates OA and L-Glu (Xenopus tropicalis)
GOT2 transaminates OA and L-Glu (Danio rerio)
IDH2 dimer decarboxylates isocitrate (Danio rerio)
IDH3 complex decarboxylates isocitrate (Rattus norvegicus)
IDH2 dimer decarboxylates isocitrate (Rattus norvegicus)
IDH2 dimer decarboxylates isocitrate (Mus musculus)
IDH2 dimer decarboxylates isocitrate (Homo sapiens)
IDH2 dimer decarboxylates isocitrate (Sus scrofa)
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Sus scrofa)
GOT2 transaminates OA and L-Glu (Sus scrofa)
IDH3 complex decarboxylates isocitrate (Sus scrofa)
IDH3 complex decarboxylates isocitrate (Mus musculus)
IDH3 complex decarboxylates isocitrate (Homo sapiens)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Saccharomyces cerevisiae)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Schizosaccharomyces pombe)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Dictyostelium discoideum)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Caenorhabditis elegans)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Drosophila melanogaster)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Xenopus tropicalis)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Danio rerio)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Sus scrofa)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Bos taurus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Canis familiaris)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Rattus norvegicus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Mus musculus)
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2] (Homo sapiens)
IDH3 complex decarboxylates isocitrate (Canis familiaris)
GOT2 transaminates OA and L-Glu (Canis familiaris)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Plasmodium falciparum)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Caenorhabditis elegans)
GOT2 transaminates OA and L-Glu (Mus musculus)
GOT2 transaminates OA and L-Glu (Homo sapiens)
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Canis familiaris)
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Mus musculus)
alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate (Rattus norvegicus)
GOT2 transaminates OA and L-Glu (Rattus norvegicus)
GOT2 transaminates OA and L-Glu (Bos taurus)
IDH3 complex decarboxylates isocitrate (Bos taurus)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Homo sapiens)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Mus musculus)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Rattus norvegicus)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Canis familiaris)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Bos taurus)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Sus scrofa)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Danio rerio)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Xenopus tropicalis)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Gallus gallus)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Drosophila melanogaster)
This entity regulates
Negatively
PC carboxylates PYR to OA
(Homo sapiens)
PC carboxylates PYR to OA
(Saccharomyces cerevisiae)
PC carboxylates PYR to OA
(Schizosaccharomyces pombe)
PC carboxylates PYR to OA
(Caenorhabditis elegans)
PC carboxylates PYR to OA
(Drosophila melanogaster)
PC carboxylates PYR to OA
(Xenopus tropicalis)
PC carboxylates PYR to OA
(Danio rerio)
PC carboxylates PYR to OA
(Sus scrofa)
PC carboxylates PYR to OA
(Mus musculus)
PC carboxylates PYR to OA
(Canis familiaris)
PC carboxylates PYR to OA
(Bos taurus)
PC carboxylates PYR to OA
(Rattus norvegicus)
Other forms of this molecule
2OG [cytoplasm]
2OG [endoplasmic reticulum lumen]
2OG [peroxisomal matrix]
2OG [nucleoplasm]
2OG [extracellular region]
2OG [cytosol]
Cross References
KNApSAcK
C00000769
AraCyc
2-KETOGLUTARATE
CAS
328-50-7
COMPOUND
C00026
PubChem Compound
164533
ZINC
ZINC000001532519
KEGG Gene
C00026
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![2OG [mitochondrial matrix] icon](/icon/R-ICO-012365.svg){kind=icon}
