PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA

Stable Identifier
R-HSA-977333
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
3-phosphooxypyruvate + L-glutamate => 2-oxoglutarate + O-phospho-L-serine, 3-phosphonooxypyruvic acid + L-glutamate = O-phospho-L-serine + 2-oxoglutarate
ReviewStatus
5/5
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PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The amino group needed for serine biosynthesis comes from glutamate (L-Glu). Its transfer onto 3-phosphonooxpyruvate (3POPA) is catalysed by PSAT1 dimer which needs pyridoxal phosphate (PXLP) as cofactor. (Baek et al. 2003)
Literature References
PubMed ID Title Journal Year
12633500 Characterization of human phosphoserine aminotransferase involved in the phosphorylated pathway of L-serine biosynthesis

Baek, JY, Jun, DY, Taub, D, Kim, YH

Biochem J 2003
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Catalyst Activity

O-phospho-L-serine:2-oxoglutarate aminotransferase activity of PXLP-K200-PSAT1 dimer [cytosol]

Physical Entity
PXLP-K200-PSAT1 dimer [cytosol] (Homo sapiens)
Activity
O-phospho-L-serine:2-oxoglutarate aminotransferase activity (GO:0004648)
Orthologous Events
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Bos taurus)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Caenorhabditis elegans)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Canis familiaris)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Danio rerio)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Dictyostelium discoideum)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Drosophila melanogaster)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Gallus gallus)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Mus musculus)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Rattus norvegicus)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Saccharomyces cerevisiae)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Schizosaccharomyces pombe)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Sus scrofa)
PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA (Xenopus tropicalis)
Cross References
RHEA
Authored
Stephan, R  (2010-10-16)
Reviewed
D'Eustachio, P  (2011-10-26)
Created
Jassal, B  (2010-10-18)
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