TAT aminates HPP

Stable Identifier
R-HSA-517444
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate
ReviewStatus
5/5
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Cytosolic tyrosine aminotransferase (TAT) catalyzes the reversible reaction of 3-(4-hydroxyphenyl)pyruvate (HPP, 4-HPPA) and glutamate to form tyrosine and alpha-keto (2-oxo) glutarate (HPP, 4-HPPA) and glutamate (Sivaraman & Kirsch, 2006). The enzymatic activity of mouse and rat homologs was also studied (Mitchell et al., 2001; Mehere et al., 2010). Unpublished crystallographic studies (PDB 3DYD) have shown TAT to be a homodimer with a pyridoxal phosphate moiety attached to lysine-280 in each monomer. Mutations in TAT can lead to tyrosinemia type 2 (TYRSN2, MIM:276600; reviewed in Scott, 2006).
Literature References
PubMed ID Title Journal Year
16640556 The narrow substrate specificity of human tyrosine aminotransferase--the enzyme deficient in tyrosinemia type II

Sivaraman, S, Kirsch, JF

FEBS J 2006
16602095 The genetic tyrosinemias

Scott, CR

Am J Med Genet C Semin Med Genet 2006
  The Metabolic and Molecular Bases of Inherited Disease, 8th ed

Beaudet, AL, Scriver, CR, Sly, WS, Valle, D

  2001
21153519 Tyrosine aminotransferase: biochemical and structural properties and molecular dynamics simulations

Bevan, DR, Robinson, H, Li, J, Vavricka, CJ, Lemkul, JA, Han, Q, Mehere, P

Protein Cell 2010
Participants
Participates
Event Information
Catalyst Activity

L-tyrosine:2-oxoglutarate aminotransferase activity of TAT dimer [cytosol]

Orthologous Events
Cross References
RHEA
Rhea
Authored
Created
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