p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate

Stable Identifier
R-HSA-517444
Type
Reaction
Species
Homo sapiens
Compartment
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Cytosolic tyrosine aminotransferase (TAT) catalyzes the reversible reaction of 3-(4-hydroxyphenyl)pyruvate and glutamate to form tyrosine and alpha-keto (2-oxo) glutarate (Mitchell et al. 2001). The enzymatic activity of the protein encoded by the cloned human TAT cDNA is inferred from the biochemical properties of its rat homologue. Unpublished crystallographic studies (PDB 3DYD) have shown TAT to be a homodimer with a pyridoxal phosphate moity attached to lysine-280 in each monomer.

Literature References
PubMed ID Title Journal Year
  The Metabolic and Molecular Bases of Inherited Disease, 8th ed

Beaudet, AL, Scriver, CR, Sly, WS, Valle, D

  2001
Participants
Participates
Event Information
Catalyst Activity

L-tyrosine:2-oxoglutarate aminotransferase activity of TAT dimer [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Created
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