oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]

Stable Identifier
R-HSA-70581
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]
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Cytosolic aspartate aminotransferase (glutamate oxaloacetate transaminase 1 - GOT1) catalyzes the reversible reaction of oxaloacetate (OA) and glutamate (L-Glu) to form aspartate (L-Asp) and 2-oxoglutarate (2OG, alpha-ketoglutarate) (Doyle et al. 1990). Unpublished crystallographic data (PBD 3IIO) suggest the enzyme is a homodimer.

Literature References
PubMed ID Title Journal Year
2241899 The amino acid sequence of cytosolic aspartate aminotransferase from human liver

Bossa, F, Doonan, S, Doyle, JM, Schinina, ME

Biochem J 1990
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Event Information
Reverse Reaction
PXLP-K259-GOT1 transaminates alpha-ketoglutarate and aspartate (Homo sapiens)
Catalyst Activity

L-aspartate:2-oxoglutarate aminotransferase activity of PXLP-K259-GOT1 dimer [cytosol]

Physical Entity
PXLP-K259-GOT1 dimer [cytosol] (Homo sapiens)
Activity
L-aspartate:2-oxoglutarate aminotransferase activity (GO:0004069)
Orthologous Events
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Bos taurus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Caenorhabditis elegans)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Canis familiaris)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Danio rerio)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Drosophila melanogaster)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Gallus gallus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Mus musculus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Rattus norvegicus)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Saccharomyces cerevisiae)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Schizosaccharomyces pombe)
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] (Sus scrofa)
Cross References
Rhea
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