17434750 |
Expression and purification of catalytically active human PHD3 in Escherichia coli
Bergquist, J,
Fedulova, N,
Hanrieder, J,
Emrén, LO
|
Protein Expr Purif |
2007 |
11292861 |
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
Gielbert, J,
Gaskell, SJ,
Maxwell, PH,
Mukherji, M,
Pugh, CW,
Mole, DR,
Kriegsheim, Av,
Jaakkola, P,
Tian, YM,
Wilson, MI,
Hebestreit, HF,
Schofield, CJ,
Ratcliffe, PJ
|
Science |
2001 |
17182618 |
Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF
Myllyharju, J,
Remes, AM,
Hirsilä, M,
Hassinen, IE,
Kivirikko, KI,
Koivunen, P
|
J Biol Chem |
2007 |
15987702 |
Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations
Wortham, NC,
Griffiths, JR,
Moat, SJ,
Pollard, PJ,
Barclay, E,
Barwell, J,
Mitchell, M,
Tomlinson, IP,
Alam, NA,
Hargreaves, IP,
Poulsom, R,
Dalgleish, A,
Heales, SJ,
Hodgson, SV,
Hunt, T,
Gleeson, MJ,
McGrath, JA,
Brière, JJ,
Rustin, P,
Chung, YL,
Olpin, S
|
Hum Mol Genet |
2005 |
15652751 |
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
MacKenzie, ED,
Boulahbel, H,
Selak, MA,
Pan, Y,
Armour, SM,
Watson, DG,
Gottlieb, E,
Mansfield, KD,
Simon, MC,
Thompson, CB
|
Cancer Cell |
2005 |
22286099 |
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity
James, V,
Webb, TM,
Sharp, TV,
Bjornsson, J,
Foxler, DE,
Longmore, GD,
Petursdottir, TE,
Constantin-Teodosiu, D,
Ingvarsson, S,
Wong, SC,
Ratcliffe, PJ,
Mee, M,
Feng, Y,
Bridge, KS
|
Nat. Cell Biol. |
2012 |
15474027 |
Determination and comparison of specific activity of the HIF-prolyl hydroxylases
Tuckerman, JR,
Mole, DR,
Hewitson, KS,
Tian, YM,
Zhao, Y,
Pugh, CW,
Ratcliffe, PJ
|
FEBS Lett |
2004 |
12788921 |
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
Hirsilä, M,
Günzler, V,
Koivunen, P,
Myllyharju, J,
Kivirikko, KI
|
J Biol Chem |
2003 |
12351678 |
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
Günzler, V,
Sorokina, I,
Gervasi, DC,
Haberberger, T,
Ivan, M,
Kaelin WG, Jr,
Kondo, K,
Conaway, JW,
Yang, H,
Michelson, KS,
Conaway, RC
|
Proc Natl Acad Sci U S A |
2002 |
15247232 |
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
Gleadle, JM,
Tian, YM,
Raval, RR,
Harris, AL,
Turley, H,
Pugh, CW,
Ratcliffe, PJ,
Appelhoff, RJ
|
J Biol Chem |
2004 |
11292862 |
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
Lane, WS,
Asara, JM,
Kim, W,
Salic, A,
Valiando, J,
Ivan, M,
Kaelin WG, Jr,
Ohh, M,
Kondo, K,
Yang, H
|
Science |
2001 |
18337469 |
Prolyl hydroxylase PHD3 activates oxygen-dependent protein aggregation
Himanen, V,
Metzen, E,
Högel, H,
Rantanen, K,
Jaakkola, PM,
Pursiheimo, J
|
Mol. Biol. Cell |
2008 |
12615973 |
Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing
Stengel, P,
Klinger, M,
Acker, H,
Hellwig-Bürgel, T,
Fandrey, J,
Wotzlaw, C,
Metzen, E,
Berchner-Pfannschmidt, U,
Huang, WQ,
Marxsen, JH,
Stolze, I,
Jelkmann, W
|
J Cell Sci |
2003 |
12912907 |
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
Benizri, E,
Pouysségur, J,
Ginouvès, A,
Volmat, V,
Roux, D,
Berra, E
|
EMBO J |
2003 |
11598268 |
A conserved family of prolyl-4-hydroxylases that modify HIF
McKnight, SL,
Bruick, RK
|
Science |
2001 |
21335549 |
Differential sensitivity of HIF hydroxylation sites to hypoxia and hydroxylase inhibitors
Willam, C,
Lee, MK,
Yeoh, KK,
Tian, YM,
Edelmann, MJ,
Kessler, BM,
Kramer, HB,
Schofield, CJ,
Pugh, CW,
Ratcliffe, PJ,
Eriksson, T
|
J Biol Chem |
2011 |