Reactome | 2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix]

2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix]

Stable Identifier

R-GGA-376887

Type

Reaction [transition]

Species

Gallus gallus

Compartment

mitochondrial matrix, mitochondrial inner membrane, cytosol

Synonyms

Exchange of cytosolic malate for mitochondrial 2-oxoglutarate

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

2-oxoglutarate [mitochondrial matrix] + malate [cytosol] <=> 2-oxoglutarate [cytosol] + malate [mitochondrial matrix]

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The exchange of cytosolic malate for mitochondrial 2-oxoglutarate (alpha-ketoglutarate) mediated by the transport protein SLC25A11 is well-studied in humans, and this exchange reaction, a key part of glucose, lipid, and amino acid metabolism seems likely to occur in chickens. OrthoMCL analysis of genomic sequences indicates that SLC25A11 is well-conserved over diverse species, but no chicken ortholog of the gene has yet been detected. This reaction is thus inferred on the hypothesis that the lack of a chicken SLC25A11 ortholog represents a gap in the chicken genomic sequence.

Participants

Input

Output