Reactome | OAT1,2,3 transport organic anions with antiport of dicarboxylic acids

OAT1,2,3 transport organic anions with antiport of dicarboxylic acids

Stable Identifier

R-HSA-561041

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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OAT1,2,3 transport organic anions with antiport of dicarboxylic acids

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The human gene SLC22A6 encodes organic anion transporter1 (OAT1). It was originally characterized in mouse as Novel Kidney Transcript (NKT). OAT1 is located on the basolateral membrane of the proximal tubule in human kidney as well as in the brain (Reid G et al, 1998; Lu R et al, 1999; Hosoyamada M et al, 1999). The human gene SLC22A7 encodes organic anion transporter 2 (OAT2) and is highly expressed in the liver and kidney (Sun W et al, 2001; Kobayashi Y et al, 2005). The human gene SLC22A8 encodes organic anion transporter 3 (OAT3) which is expressed mainly in the brain and kidney (Race JE et al, 1999; Bakhiya A et al, 2003).
OAT1, OAT2, and OAT3 transport organic anions such as p-aminohippurate, urate, and cyclic GMP (Henjakovic et al. 2015, Uchida et al. 2003, Bakhiya et al. 2003), and drugs such as cimetidine and acyclovir. This transport is is coupled with an efflux of one molecule of endogenous dicarboxylic acid such as alpha-ketoglutarate (2-oxoglutarate). OAT2 is classified as both a transporter of organic anions and sulphate conjugates.

Literature References

PubMed ID	Title	Journal	Year
14586168	Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux Bakhiya, A, Bahn, A, Burckhardt, G, Wolff, N	Cell Physiol Biochem	2003
11327718	Isolation of a family of organic anion transporters from human liver and kidney Sun, W, Wu, RR, van Poelje, PD, Erion, MD	Biochem Biophys Res Commun	2001
26377792	Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function Henjakovic, M, Hagos, Y, Krick, W, Burckhardt, G, Burckhardt, BC	Am J Physiol Renal Physiol	2015
12472777	Urate transport via human PAH transporter hOAT1 and its gene structure Ichida, K, Hosoyamada, M, Kimura, H, Takeda, M, Utsunomiya, Y, Hosoya, T, Endou, H	Kidney Int	2003
10049739	Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3) Race, JE, Grassl, SM, Williams, WJ, Holtzman, EJ	Biochem Biophys Res Commun	1999
15901346	Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]) Kobayashi, Y, Ohshiro, N, Sakai, R, Ohbayashi, M, Kohyama, N, Yamamoto, T	J Pharm Pharmacol	2005
9950961	Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C Lu, R, Chan, BS, Schuster, VL	Am J Physiol	1999
9887087	Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney Hosoyamada, M, Sekine, T, Kanai, Y, Endou, H	Am J Physiol	1999
9762842	Cloning of a human renal p-aminohippurate transporter, hROAT1 Reid, G, Wolff, NA, Dautzenberg, FM, Burckhardt, G	Kidney Blood Press Res	1998