OAT1-3 transport organic anions with antiport of dicarboxylic acids

Stable Identifier
R-HSA-561041
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The human gene SLC22A6 encodes organic anion transporter1 (OAT1). It was originally characterized in mouse as Novel Kidney Transcript (NKT). OAT1 is located on the basolateral membrane of the proximal tubule in human kidney as well as in the brain (Reid G et al, 1998; Lu R et al, 1999; Hosoyamada M et al, 1999). The human gene SLC22A7 encodes organic anion transporter 2 (OAT2) and is highly expressed in the liver and kidney (Sun W et al, 2001; Kobayashi Y et al, 2005). The human gene SLC22A8 encodes organic anion transporter 3 (OAT3) which is expressed mainly in the brain and kidney (Race JE et al, 1999; Bakhiya A et al, 2003).
OAT1-3 transport organic anions such as p-aminohippurate and drugs such as cimetidine and acyclovir. This transport is is coupled with an efflux of one molecule of endogenous dicarboxylic acid such as alpha-ketoglutarate (2-oxoglutarate). OAT2 is classified as both a transporter of organic anions and sulphate conjugates.

Literature References
PubMed ID Title Journal Year
11327718 Isolation of a family of organic anion transporters from human liver and kidney

Sun, W, Wu, RR, van Poelje, PD, Erion, MD

Biochem Biophys Res Commun 2001
14586168 Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux

Bakhiya, A, Bahn, A, Burckhardt, G, Wolff, N

Cell Physiol Biochem 2003
10049739 Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)

Race, JE, Grassl, SM, Williams, WJ, Holtzman, EJ

Biochem Biophys Res Commun 1999
15901346 Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7])

Kobayashi, Y, Ohshiro, N, Sakai, R, Ohbayashi, M, Kohyama, N, Yamamoto, T

J Pharm Pharmacol 2005
9950961 Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C

Lu, R, Chan, BS, Schuster, VL

Am J Physiol 1999
9887087 Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney

Hosoyamada, M, Sekine, T, Kanai, Y, Endou, H

Am J Physiol 1999
9762842 Cloning of a human renal p-aminohippurate transporter, hROAT1

Reid, G, Wolff, NA, Dautzenberg, FM, Burckhardt, G

Kidney Blood Press Res 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
anion:anion antiporter activity of OAT1-3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created
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