Reactome | GRB2-1:SOS1 [cytosol]

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GRB2-1:SOS1 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9733324] CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:GRB2:SOS1 [plasma membrane] - Homo sapiens [Complex:R-HSA-9029089] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:SOS1 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9733330] CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-5637770] Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII - Homo sapiens [Reaction:R-HSA-5637798] Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex - Homo sapiens [Reaction:R-HSA-1225961] Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex - Homo sapiens [Reaction:R-HSA-1225950] Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants - Homo sapiens [Reaction:R-HSA-9672158] GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers - Homo sapiens [Reaction:R-HSA-9672164] GRB2:SOS1 complex binds to mutant PDGFR receptor - Homo sapiens [Reaction:R-HSA-9670428] KIT mutants bind GRB2-SOS - Homo sapiens [Reaction:R-HSA-5655266] Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1 - Homo sapiens [Reaction:R-HSA-5685366] GRB2-1:SOS1 binds p-Y-SHC - Homo sapiens [Reaction:R-HSA-5686073] GRB2-1:SOS1 binds p-3Y-SHC1 - Homo sapiens [Reaction:R-HSA-74746] GRB2-1:SOS1 binds p-Y427-SHC1 - Homo sapiens [Reaction:R-HSA-2179415] GRB2:SOS1 binds to HBEGF:p-Y-EGFR - Homo sapiens [Reaction:R-HSA-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Homo sapiens [Reaction:R-HSA-1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer - Homo sapiens [Reaction:R-HSA-205286] GRB2:SOS interacts with p-KIT - Homo sapiens [Reaction:R-HSA-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 - Homo sapiens [Reaction:R-HSA-1250380] Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers - Homo sapiens [Reaction:R-HSA-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Homo sapiens [Reaction:R-HSA-1306969] GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers - Homo sapiens [Reaction:R-HSA-9029149] EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-9634402] Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer - Homo sapiens [Reaction:R-HSA-9665409] GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR - Homo sapiens [Reaction:R-HSA-9665413] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1 - Homo sapiens [Reaction:R-HSA-9664983] Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1 - Homo sapiens [Reaction:R-HSA-9665000] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-9665698] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-9665699] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1 - Homo sapiens [Reaction:R-HSA-5655348] Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1 - Homo sapiens [Reaction:R-HSA-5655233] Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1 - Homo sapiens [Reaction:R-HSA-5655295] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1 - Homo sapiens [Reaction:R-HSA-9028328] SHC1 bound to activated NTRK2 recruits GRB2:SOS1 - Homo sapiens [BlackBoxEvent:R-HSA-9032073] NTRK2-phosphorylated FRS2 binds GRB2 - Homo sapiens [BlackBoxEvent:R-HSA-9036949] NTRK3 binds GRB2:SOS1 through SHC1 - Homo sapiens [Reaction:R-HSA-8851900] SHC1-2 bound to MET recruits GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-8851804] Activated MET recruits GRB2-1:SOS1 - Homo sapiens [Reaction:R-HSA-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 - Homo sapiens [Reaction:R-HSA-453111] Phosphorylated SHC recruits GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-5654586] Activated FGFR1:p-FRS binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-1250486] Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers - Homo sapiens [Reaction:R-HSA-5654646] Activated FGFR3:p-SHC1 binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-2730844] Interaction of GRB2:SOS complex with p-SHC1 - Homo sapiens [Reaction:R-HSA-5654597] Activated FGFR1:p-SHC1 binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR - Homo sapiens [Reaction:R-HSA-5654615] Activated FGFR2:pFRS binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-5654423] Activated FGFR4:p-SHC1 binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-5654416] Activated FGFR3:pFRS binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-186826] GRB2:SOS1 complex binds to the active receptor - Homo sapiens [Reaction:R-HSA-5654406] Activated FGFR2:p-SHC1 binds GRB2:SOS1 - Homo sapiens
created	[InstanceEdit:109781] Schmidt, EE, 2004-01-21 04:32:59
dbId	109797
displayName	GRB2-1:SOS1 [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-HSA-74686] GRB2-1 [cytosol] [EntityWithAccessionedSequence:R-HSA-64847] SOS1 [cytosol]
inDisease	false
inferredTo	[Complex:R-MMU-109797] GRB2-1:SOS1 [cytosol] - Mus musculus [Complex:R-RNO-109797] GRB2-1:SOS1 [cytosol] - Rattus norvegicus [Complex:R-CFA-109797] GRB2-1:SOS1 [cytosol] - Canis familiaris [Complex:R-BTA-109797] GRB2-1:SOS1 [cytosol] - Bos taurus [Complex:R-SSC-109797] GRB2-1:SOS1 [cytosol] - Sus scrofa [Complex:R-DRE-109797] GRB2-1:SOS1 [cytosol] - Danio rerio [Complex:R-XTR-109797] GRB2-1:SOS1 [cytosol] - Xenopus tropicalis [Complex:R-GGA-109797] GRB2-1:SOS1 [cytosol] - Gallus gallus [Complex:R-DME-109797] GRB2-1:SOS1 [cytosol] - Drosophila melanogaster [Complex:R-CEL-109797] GRB2-1:SOS1 [cytosol] - Caenorhabditis elegans
literatureReference	[LiteratureReference:9029032] Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells [LiteratureReference:179827] Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
modified	[InstanceEdit:9029143] May, Bruce, 2017-11-14
name	GRB2-1:SOS1
producedByEvent	[Reaction:R-HSA-9733331] CSF1 dimer,IL34 dimer:p-Y561-CSF1R:GRB2:SOS1 dissociates yielding CSF1 dimer,IL34 dimer:p-Y561-CSF1R:SFK and GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-109813] GRB2-1 binds SOS1 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-109797

Referrals

(hasComponent)	[Complex:R-HSA-9029089] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-9733324] CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-5637697] p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-5637704] p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-1225856] Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-1225859] Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-9672071] p-11Y PDGFRA extracellular domain dimers:GRB2:SOS1 [endoplasmic reticulum membrane] [Complex:R-HSA-9672059] p-11Y PDGFR mutatnt receptors:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-9634404] p-ERBB2 homodimer:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-9665449] p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-9665437] p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-9664981] Phosphorylated heterodimers of ERBB2 KD mutants:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-9664996] p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-9665916] p-6Y-ERBB2 TMD/JMD mutants (RAS):EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-9665869] p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-9670365] p-KIT mutants:GRB2:SOS [plasma membrane] [Complex:R-HSA-5655342] FGFR4 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-5655345] FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-5655307] FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-9028334] BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3):GRB2-1:SOS1 [plasma membrane] [Complex:R-HSA-9032071] BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:GRB2-1:SOS1 [plasma membrane] [Complex:R-HSA-9036947] NTF3:p-5Y-NTRK3 homodimer:p-Y-SHC1:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-5686070] GRB2-1:SOS1:p-3Y-SHC1 [cytosol] [Complex:R-HSA-186827] PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] [Complex:R-HSA-921157] Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-5654296] Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-1306947] NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-5654343] Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-205202] GRB2:SOS1:p-KIT complex [plasma membrane] [Complex:R-HSA-5654275] Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-8851807] HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] [Complex:R-HSA-5654287] Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-1250505] EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] [Complex:R-HSA-5654327] Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-5685367] GRB2-1:SOS1:p-Y-SHC [cytosol] [Complex:R-HSA-109798] GRB2-1:SOS1:p-Y427-SHC1 [cytosol] [Complex:R-HSA-109800] GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] [Complex:R-HSA-180331] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-5654264] Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-179820] EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-2685672] p-SHC1:GRB2:SOS [cytosol] [Complex:R-HSA-2179409] GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] [Complex:R-HSA-8854903] 2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] [Complex:R-HSA-5654308] Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-8854399] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] [Complex:R-HSA-5654316] Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] [Complex:R-HSA-1250479] GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] [Complex:R-HSA-8851897] HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane]
(input)	[Reaction:R-HSA-9029149] EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 [Reaction:R-HSA-9733330] CSF1 dimer,IL34 dimer:p-Y561-CSF1R dimer:SFK binds GRB2:SOS1 [Reaction:R-HSA-5637770] Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII [Reaction:R-HSA-5637798] Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex [Reaction:R-HSA-1225961] Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex [Reaction:R-HSA-1225950] Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants [Reaction:R-HSA-9672158] GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers [Reaction:R-HSA-9672164] GRB2:SOS1 complex binds to mutant PDGFR receptor [Reaction:R-HSA-9634402] Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer [Reaction:R-HSA-9665409] GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR [Reaction:R-HSA-9665413] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1 [Reaction:R-HSA-9664983] Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1 [Reaction:R-HSA-9665000] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1 [Reaction:R-HSA-9665698] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1 [Reaction:R-HSA-9665699] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1 [Reaction:R-HSA-9670428] KIT mutants bind GRB2-SOS [Reaction:R-HSA-5655348] Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1 [Reaction:R-HSA-5655233] Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1 [Reaction:R-HSA-5655295] Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1 [Reaction:R-HSA-5655266] Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1 [Reaction:R-HSA-9028328] SHC1 bound to activated NTRK2 recruits GRB2:SOS1 [BlackBoxEvent:R-HSA-9032073] NTRK2-phosphorylated FRS2 binds GRB2 [BlackBoxEvent:R-HSA-9036949] NTRK3 binds GRB2:SOS1 through SHC1 [Reaction:R-HSA-5685366] GRB2-1:SOS1 binds p-Y-SHC [Reaction:R-HSA-5686073] GRB2-1:SOS1 binds p-3Y-SHC1 [Reaction:R-HSA-8851900] SHC1-2 bound to MET recruits GRB2:SOS1 [Reaction:R-HSA-74746] GRB2-1:SOS1 binds p-Y427-SHC1 [Reaction:R-HSA-2179415] GRB2:SOS1 binds to HBEGF:p-Y-EGFR [Reaction:R-HSA-8851804] Activated MET recruits GRB2-1:SOS1 [Reaction:R-HSA-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 [Reaction:R-HSA-453111] Phosphorylated SHC recruits GRB2:SOS1 [Reaction:R-HSA-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 [Reaction:R-HSA-5654586] Activated FGFR1:p-FRS binds GRB2:SOS1 [Reaction:R-HSA-1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer [Reaction:R-HSA-205286] GRB2:SOS interacts with p-KIT [Reaction:R-HSA-1250486] Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers [Reaction:R-HSA-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 [Reaction:R-HSA-5654646] Activated FGFR3:p-SHC1 binds GRB2:SOS1 [Reaction:R-HSA-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 [Reaction:R-HSA-1250380] Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers [Reaction:R-HSA-177943] GRB2:SOS1 complex binds to EGF:EGFR complex [Reaction:R-HSA-2730844] Interaction of GRB2:SOS complex with p-SHC1 [Reaction:R-HSA-5654597] Activated FGFR1:p-SHC1 binds GRB2:SOS1 [Reaction:R-HSA-177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR [Reaction:R-HSA-5654615] Activated FGFR2:pFRS binds GRB2:SOS1 [Reaction:R-HSA-5654423] Activated FGFR4:p-SHC1 binds GRB2:SOS1 [Reaction:R-HSA-5654416] Activated FGFR3:pFRS binds GRB2:SOS1 [Reaction:R-HSA-186826] GRB2:SOS1 complex binds to the active receptor [Reaction:R-HSA-1306969] GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers [Reaction:R-HSA-5654406] Activated FGFR2:p-SHC1 binds GRB2:SOS1
(output)	[Reaction:R-HSA-9733331] CSF1 dimer,IL34 dimer:p-Y561-CSF1R:GRB2:SOS1 dissociates yielding CSF1 dimer,IL34 dimer:p-Y561-CSF1R:SFK and GRB2:SOS1 [Reaction:R-HSA-109813] GRB2-1 binds SOS1
(activeUnit)	[CatalystActivity:9672166] guanyl-nucleotide exchange factor activity of p-11Y PDGFRA extracellular domain dimers:GRB2:SOS1 [endoplasmic reticulum membrane] [CatalystActivity:9634417] guanyl-nucleotide exchange factor activity of p-ERBB2 homodimer:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] [CatalystActivity:8851826] guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane]

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