Reactome | GRB2-1:SOS1 binds p-IRS1,p-IRS2

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GRB2-1:SOS1 binds p-IRS1,p-IRS2 Show undefined attributes

authored	[InstanceEdit:157820] Charalambous, M, 2005-01-07 11:17:43
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:112400] Charalambous, M, 2004-04-29 09:21:24
dbId	74736
displayName	GRB2-1:SOS1 binds p-IRS1,p-IRS2
edited	[InstanceEdit:165100] Schmidt, EE, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-112412] SOS-mediated signalling - Homo sapiens
figure	[Figure:157818] /figures/Grb2_IRS.jpg
followingEvent	[Reaction:R-HSA-109817] GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS - Homo sapiens [Reaction:R-HSA-109823] MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 - Homo sapiens [Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange - Homo sapiens
input	[Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol] [DefinedSet:R-HSA-112322] p-Y-IRS1,p-Y-IRS2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:110025] Interactions between Src homology SH2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor. [LiteratureReference:110026] The function of GRB2 in linking the insulin receptor to Ras signaling pathways. [LiteratureReference:2428918] Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling [LiteratureReference:2445099] Differential regulation of insulin receptor substrate-2 and mitogen-activated protein kinase tyrosine phosphorylation by phosphatidylinositol 3-kinase inhibitors in SH-SY5Y human neuroblastoma cells [LiteratureReference:2445113] Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts [LiteratureReference:2424290] Substrate specificities of the insulin and insulin-like growth factor 1 receptor tyrosine kinase catalytic domains [LiteratureReference:2454051] Systematic mapping of potential binding sites for Shc and Grb2 SH2 domains on insulin receptor substrate-1 and the receptors for insulin, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	GRB2-1:SOS1 binds p-IRS1,p-IRS2
negativePrecedingEvent	[NegativePrecedingEvent:9865954] Futile Cycle: GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates
orthologousEvent	[Reaction:R-GGA-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Gallus gallus [Reaction:R-XTR-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Xenopus tropicalis [Reaction:R-DME-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Drosophila melanogaster [Reaction:R-DRE-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Danio rerio [Reaction:R-SSC-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Sus scrofa [Reaction:R-BTA-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Bos taurus [Reaction:R-CFA-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Canis familiaris [Reaction:R-RNO-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Rattus norvegicus [Reaction:R-MMU-74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - Mus musculus
output	[Complex:R-HSA-109800] GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]
precedingEvent	[Reaction:R-HSA-74712] Dissociation of IRS-P from insulin receptor - Homo sapiens [Reaction:R-HSA-109813] GRB2-1 binds SOS1 - Homo sapiens
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-74736
summation	[Summation:77424] Inactive p21ras:GDP is anchored to the plasma membrane by a ...
updateTrackers	[UpdateTracker:9788335] Update Tracker - [Reaction:74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - v42:[addLiteratureReference] [UpdateTracker:9784853] Update Tracker - [Reaction:74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - v53:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9788335] Update Tracker - [Reaction:74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - v42:[addLiteratureReference] [UpdateTracker:9784853] Update Tracker - [Reaction:74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 - v53:[modifyText]
(hasEvent)	[Pathway:R-HSA-112412] SOS-mediated signalling
(precedingEvent)	[Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange [Reaction:R-HSA-109817] GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS [Reaction:R-HSA-109823] MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2

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