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Schema
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Reaction
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Entries
Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
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authored
[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category
binding
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
dbId
5655266
disease
[Disease:1500689] cancer
[Disease:2032940] bone development disease
displayName
Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
edited
[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus
[EntityFunctionalStatus:5655256] gain_of_function of Activated FGFR1 mutants:p-FRS2 [plasma membrane]
eventOf
[Pathway:R-HSA-5655302] Signaling by FGFR1 in disease - Homo sapiens
followingEvent
[Reaction:R-HSA-5655326] Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens
input
[Complex:R-HSA-5655216] Activated FGFR1 mutants:p-FRS2 [plasma membrane]
[Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
[LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
[LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer
[LiteratureReference:1295608] Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4
[LiteratureReference:2054036] Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
normalReaction
[Reaction:R-HSA-5654586] Activated FGFR1:p-FRS binds GRB2:SOS1
output
[Complex:R-HSA-5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
precedingEvent
[Reaction:R-HSA-5655278] Activated FGFR1 mutants phosphorylate FRS2 - Homo sapiens
releaseDate
2012-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5655266
summation
[Summation:1982079] Activation of FGFR mutants has in some cases been shown to r...
Referrals
(precedingEvent)
[Reaction:R-HSA-5655326] Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
(hasEvent)
[Pathway:R-HSA-5655302] Signaling by FGFR1 in disease
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