Reactome | Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1

Schema > Reaction > Entries

Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1 Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
crossReference	[DatabaseIdentifier:12020828] Mondo:0005497
dbId	5655266
deleted	[Deleted:5655668] Deletion of instance: 1982082
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5655256] gain_of_function of Activated FGFR1 mutants:p-FRS2 [plasma membrane]
eventOf	[Pathway:R-HSA-5655302] Signaling by FGFR1 in disease - Homo sapiens
followingEvent	[Reaction:R-HSA-5655326] Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens
input	[Complex:R-HSA-5655216] Activated FGFR1 mutants:p-FRS2 [plasma membrane] [Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1982028] Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer [LiteratureReference:1982030] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer [LiteratureReference:2045066] Fibroblast growth factors and their receptors in cancer [LiteratureReference:1295608] Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4 [LiteratureReference:2054036] Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1
normalReaction	[Reaction:R-HSA-5654586] Activated FGFR1:p-FRS binds GRB2:SOS1
output	[Complex:R-HSA-5655328] FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-5655278] Activated FGFR1 mutants phosphorylate FRS2 - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5655266
summation	[Summation:1982079] Activation of FGFR mutants has in some cases been shown to r...

Referrals

(replacementInstances)	[Deleted:5655668] Deletion of instance: 1982082
(precedingEvent)	[Reaction:R-HSA-5655326] Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
(hasEvent)	[Pathway:R-HSA-5655302] Signaling by FGFR1 in disease

Cite Us!