Reactome | p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1:GRB2:SOS1 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:9665880] guanyl-nucleotide exchange factor activity of p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1:GRB2:SOS1 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9665888] Orlic-Milacic, Marija, 2019-11-01
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9665869
disease	[Disease:1500689] cancer
displayName	p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1:GRB2:SOS1 [plasma membrane]
hasComponent	[Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol] [Complex:R-HSA-9665882] p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1 [plasma membrane]
inDisease	true
includedLocation	[Compartment:70101] cytosol
isChimeric	false
maxDepth	8
name	p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1:GRB2:SOS1
producedByEvent	[Reaction:R-HSA-9665699] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9665869

(diseaseEntity)	[EntityFunctionalStatus:9665868] gain_of_function of p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1:GRB2:SOS1 [plasma membrane]
(physicalEntity)	[CatalystActivity:9665880] guanyl-nucleotide exchange factor activity of p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1:GRB2:SOS1 [plasma membrane]
(output)	[Reaction:R-HSA-9665699] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1

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