Reactome | SHC1 bound to activated NTRK2 recruits GRB2:SOS1

Schema > Reaction > Entries

authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9028326] Orlic-Milacic, Marija, 2017-11-07
dbId	9028328
displayName	SHC1 bound to activated NTRK2 recruits GRB2:SOS1
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
eventOf	[Pathway:R-HSA-9026519] Activated NTRK2 signals through RAS - Homo sapiens
followingEvent	[Reaction:R-HSA-9026891] NTRK2 activates RAS signaling through SHC1 - Homo sapiens
inferredFrom	[Reaction:R-RNO-9030518] Shc1 bound to activated Ntrk2 recruits Grb2:Sos1 - Rattus norvegicus
input	[Complex:R-HSA-9028330] BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3) [plasma membrane] [Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SHC1 bound to activated NTRK2 recruits GRB2:SOS1
output	[Complex:R-HSA-9028334] BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3):GRB2-1:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9026890] NTRK2 phosphorylates SHC1 - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9028328
summation	[Summation:9028336] NTRK2 (TRKB)-mediated activation of RAS signaling downstream...

(precedingEvent)	[Reaction:R-HSA-9026891] NTRK2 activates RAS signaling through SHC1
(hasEvent)	[Pathway:R-HSA-9026519] Activated NTRK2 signals through RAS
(inferredTo)	[Reaction:R-RNO-9030518] Shc1 bound to activated Ntrk2 recruits Grb2:Sos1

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