Reactome | NTRK3 binds GRB2:SOS1 through SHC1

Schema > BlackBoxEvent > Entries

authored	[InstanceEdit:9034018] Orlic-Milacic, Marija, 2018-01-02
category	uncertain
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9036948] Orlic-Milacic, Marija, 2018-02-14
dbId	9036949
displayName	NTRK3 binds GRB2:SOS1 through SHC1
edited	[InstanceEdit:9608101] Orlic-Milacic, Marija, 2018-05-09
eventOf	[Pathway:R-HSA-9034864] Activated NTRK3 signals through RAS - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9036970] NTRK3 activates RAS through SHC1 - Homo sapiens
inferredFrom	[BlackBoxEvent:R-NUL-9036961] Ntrk3 binds Grb2 through Shc1 - Homo sapiens
input	[Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol] [Complex:R-HSA-9034877] NTF3:p-5Y-NTRK3 homodimer:p-Y-SHC1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NTRK3 binds GRB2:SOS1 through SHC1
output	[Complex:R-HSA-9036947] NTF3:p-5Y-NTRK3 homodimer:p-Y-SHC1:GRB2:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9034875] NTRK3 phosphorylates SHC1 - Homo sapiens
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608098] Tsoulfas, Pantelis, 2018-05-09
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9036949
summation	[Summation:9036954] SHC1, phosphorylated by NTRK3 (TRKC), binds GRB2. Based on s...

(hasEvent)	[Pathway:R-HSA-9034864] Activated NTRK3 signals through RAS
(precedingEvent)	[BlackBoxEvent:R-HSA-9036970] NTRK3 activates RAS through SHC1
(inferredTo)	[BlackBoxEvent:R-NUL-9036961] Ntrk3 binds Grb2 through Shc1

Cite Us!