Reactome | EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1

Schema > Reaction > Entries

EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1 Show undefined attributes

authored	[InstanceEdit:9029159] May, Bruce, 2017-11-11
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9029161] May, Bruce, 2017-11-14
dbId	9029149
displayName	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1
edited	[InstanceEdit:9029159] May, Bruce, 2017-11-11
eventOf	[Pathway:R-HSA-9027284] Erythropoietin activates RAS - Homo sapiens
followingEvent	[Reaction:R-HSA-9029158] EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS - Homo sapiens
inferredFrom	[Reaction:R-MMU-9029146] Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1 binds Grb2-1:Sos1 - Mus musculus
input	[Complex:R-HSA-9029088] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1 [plasma membrane] [Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9029007] The signal transduction through Grb2/Ash in hematopoietic cells [LiteratureReference:9029077] Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1
output	[Complex:R-HSA-9029089] EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9029155] JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1 - Homo sapiens
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9616793] McGraw, Kathy L, 2018-08-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9029149
summation	[Summation:9030358] Phosphorylated SHC1 in the EPOR complex serves as a scaffold...

Referrals

(precedingEvent)	[Reaction:R-HSA-9029158] EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS
(hasEvent)	[Pathway:R-HSA-9027284] Erythropoietin activates RAS
(inferredTo)	[Reaction:R-MMU-9029146] Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1 binds Grb2-1:Sos1

Cite Us!