Reactome | GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer

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GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer Show undefined attributes

authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1250503] Orlic-Milacic, Marija, 2011-04-21
dbId	1250488
diseaseReaction	[Reaction:R-HSA-9665409] GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR - Homo sapiens [Reaction:R-HSA-9665000] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-9665698] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1 - Homo sapiens
displayName	GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07
eventOf	[Pathway:R-HSA-1963640] GRB2 events in ERBB2 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-1250498] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers - Homo sapiens [Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange - Homo sapiens
inferredFrom	[Reaction:R-NUL-1250475] Direct recruitment of GRB2:Sos1 to P-Erbb2mut dimer - Homo sapiens
input	[Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol] [CandidateSet:R-HSA-1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:1250467] Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu
maxDepth	1
modified	[InstanceEdit:9866055] Orlic-Milacic, Marija, 2024-03-20
name	GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
negativePrecedingEvent	[NegativePrecedingEvent:9866037] Futile Cycle: ERBB2 promotes PTK6 autophosphorylation [NegativePrecedingEvent:9866011] Futile Cycle: PLCG1 phosphorylation by p-EGFR:p-ERBB2
output	[Complex:R-HSA-1250505] EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-1963582] Trans-autophosphorylation of ERBB2 heterodimers - Homo sapiens [Reaction:R-HSA-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1972347] Neckers, LM, 2011-11-11 [InstanceEdit:1972346] Xu, W, 2011-11-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1250488
summation	[Summation:1250497] Phosphorylated ERBB2:EGFR heterodimer recruits GRB2:SOS1 com...
updateTrackers	[UpdateTracker:9777516] Update Tracker - [Reaction:1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer - v70:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9777516] Update Tracker - [Reaction:1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer - v70:[modifyText]
(normalReaction)	[Reaction:R-HSA-9665409] GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR [Reaction:R-HSA-9665000] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1 [Reaction:R-HSA-9665698] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1
(hasEvent)	[Pathway:R-HSA-1963640] GRB2 events in ERBB2 signaling
(precedingEvent)	[Reaction:R-HSA-1250498] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers [Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange
(inferredTo)	[Reaction:R-NUL-1250475] Direct recruitment of GRB2:Sos1 to P-Erbb2mut dimer