Reactome | GRB2:SOS1 complex binds to EGF:EGFR complex

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GRB2:SOS1 complex binds to EGF:EGFR complex Show undefined attributes

authored	[InstanceEdit:188408] Castagnoli, L, 2006-10-10 13:09:34
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:177921] Jassal, Bijay, 2006-04-11
dbId	177943
diseaseReaction	[Reaction:R-HSA-5637770] Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII - Homo sapiens [Reaction:R-HSA-1225950] Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants - Homo sapiens
displayName	GRB2:SOS1 complex binds to EGF:EGFR complex
edited	[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
eventOf	[Pathway:R-HSA-179812] GRB2 events in EGFR signaling - Homo sapiens
figure	[Figure:179463] /figures/sos_gbr2_binds_egfr_egf.jpg
followingEvent	[Reaction:R-HSA-177938] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) - Homo sapiens [Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange - Homo sapiens
input	[Complex:R-HSA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] [Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:179801] Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells [LiteratureReference:179887] Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	GRB2:SOS1 complex binds to EGF:EGFR complex
negativePrecedingEvent	[NegativePrecedingEvent:9865815] Futile Cycle: Active PLC-gamma1 dissociates from EGFR
orthologousEvent	[Reaction:R-CEL-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Caenorhabditis elegans [Reaction:R-DME-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Drosophila melanogaster [Reaction:R-GGA-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Gallus gallus [Reaction:R-XTR-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Xenopus tropicalis [Reaction:R-DRE-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Danio rerio [Reaction:R-SSC-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Sus scrofa [Reaction:R-BTA-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Bos taurus [Reaction:R-CFA-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Canis familiaris [Reaction:R-RNO-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Rattus norvegicus [Reaction:R-MMU-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Mus musculus
output	[Complex:R-HSA-179820] EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-109813] GRB2-1 binds SOS1 - Homo sapiens [Reaction:R-HSA-177934] EGFR autophosphorylation - Homo sapiens [Reaction:R-HSA-177937] Phosphorylation of EGFR by SRC kinase - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-177943
summation	[Summation:188438] Cytoplasmic target proteins containing the SH2 domain can bi...
updateTrackers	[UpdateTracker:9778967] Update Tracker - [Reaction:177943] GRB2:SOS1 complex binds to EGF:EGFR complex - v67:[add_removeInput] [UpdateTracker:9846639] Update Tracker - [Reaction:177943] GRB2:SOS1 complex binds to EGF:EGFR complex - v84:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9778967] Update Tracker - [Reaction:177943] GRB2:SOS1 complex binds to EGF:EGFR complex - v67:[add_removeInput] [UpdateTracker:9846639] Update Tracker - [Reaction:177943] GRB2:SOS1 complex binds to EGF:EGFR complex - v84:[modifyText]
(normalReaction)	[Reaction:R-HSA-5637770] Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII [Reaction:R-HSA-1225950] Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants
(hasEvent)	[Pathway:R-HSA-179812] GRB2 events in EGFR signaling
(precedingEvent)	[Reaction:R-HSA-177938] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) [Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange

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