Reactome | GRB2:SOS1 binds to HBEGF:p-Y-EGFR

Schema > Reaction > Entries

GRB2:SOS1 binds to HBEGF:p-Y-EGFR Show undefined attributes

authored	[InstanceEdit:2186599] Jassal, Bijay, Tripathi, S, 2012-04-04
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2179414] Jassal, B, 2012-04-04
dbId	2179415
displayName	GRB2:SOS1 binds to HBEGF:p-Y-EGFR
edited	[InstanceEdit:2186599] Jassal, Bijay, Tripathi, S, 2012-04-04
eventOf	[Pathway:R-HSA-2179392] EGFR Transactivation by Gastrin - Homo sapiens
followingEvent	[Reaction:R-HSA-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) - Homo sapiens [Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange - Homo sapiens
input	[Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol] [Complex:R-HSA-2179410] HB-EGF:p-6Y-EGFR dimer [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:179887] Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor [LiteratureReference:179801] Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	GRB2:SOS1 binds to HBEGF:p-Y-EGFR
orthologousEvent	[Reaction:R-GGA-2179415] GRB2:SOS1 binds to HBEGF:p-Y-EGFR - Gallus gallus [Reaction:R-XTR-2179415] GRB2:SOS1 binds to HBEGF:p-Y-EGFR - Xenopus tropicalis [Reaction:R-DRE-2179415] GRB2:SOS1 binds to HBEGF:p-Y-EGFR - Danio rerio [Reaction:R-SSC-2179415] GRB2:SOS1 binds to HBEGF:p-Y-EGFR - Sus scrofa [Reaction:R-BTA-2179415] GRB2:SOS1 binds to HBEGF:p-Y-EGFR - Bos taurus [Reaction:R-CFA-2179415] GRB2:SOS1 binds to HBEGF:p-Y-EGFR - Canis familiaris [Reaction:R-RNO-2179415] GRB2:SOS1 binds to HBEGF:p-Y-EGFR - Rattus norvegicus [Reaction:R-MMU-2179415] GRB2:SOS1 binds to HBEGF:p-Y-EGFR - Mus musculus
output	[Complex:R-HSA-2179409] GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-2179387] Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2206192] D'Eustachio, P, 2012-04-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2179415
summation	[Summation:2179394] Cytoplasmic target proteins containing the SH2 domain can bi...

Referrals

(precedingEvent)	[Reaction:R-HSA-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) [Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange
(hasEvent)	[Pathway:R-HSA-2179392] EGFR Transactivation by Gastrin