Reactome | Activated FGFR4:p-FRS binds GRB2:SOS1

Schema > Reaction > Entries

Activated FGFR4:p-FRS binds GRB2:SOS1 Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654666] Rothfels, Karen, 2014-12-03
dbId	5654664
deleted	[Deleted:5655561] Deletion of instance: 1268255
diseaseReaction	[Reaction:R-HSA-5655348] Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1 - Homo sapiens
displayName	Activated FGFR4:p-FRS binds GRB2:SOS1
eventOf	[Pathway:R-HSA-5654712] FRS-mediated FGFR4 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-5654663] Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens [Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange - Homo sapiens
input	[DefinedSet:R-HSA-5654324] Activated FGFR4:p-FRS [plasma membrane] [Complex:R-HSA-109797] GRB2-1:SOS1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:189823] A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway [LiteratureReference:191045] Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins [LiteratureReference:532232] Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2 [LiteratureReference:532244] Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells [LiteratureReference:191015] Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Activated FGFR4:p-FRS binds GRB2:SOS1
orthologousEvent	[Reaction:R-CEL-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Caenorhabditis elegans [Reaction:R-DME-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Drosophila melanogaster [Reaction:R-GGA-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Gallus gallus [Reaction:R-XTR-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Xenopus tropicalis [Reaction:R-DRE-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Danio rerio [Reaction:R-SSC-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Sus scrofa [Reaction:R-BTA-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Bos taurus [Reaction:R-CFA-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Canis familiaris [Reaction:R-RNO-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Rattus norvegicus [Reaction:R-MMU-5654664] Activated FGFR4:p-FRS binds GRB2:SOS1 - Mus musculus
output	[Complex:R-HSA-5654327] Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-5654418] Activated FGFR4 phosphorylates FRS2 - Homo sapiens [Reaction:R-HSA-5654653] Activated FGFR4 phosphorylates FRS3 - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654664
summation	[Summation:1268254] Tyrosine phosphorylated FRS2 recruits GRB2:SOS1 complex by m...

Referrals

(replacementInstances)	[Deleted:5655561] Deletion of instance: 1268255
(normalReaction)	[Reaction:R-HSA-5655348] Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1
(hasEvent)	[Pathway:R-HSA-5654712] FRS-mediated FGFR4 signaling
(precedingEvent)	[Reaction:R-HSA-5654663] Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange

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